Evaluación del neurodesarrollo en niños con exposición intrauterina al virus del Zika: estudio observacional transversal

El virus del Zika produce desenlaces adversos para el desarrollo del sistema nervioso. Este estudio describe el neurodesarrollo cognitivo, adaptativo, comunicativo, social y motor de niños expuestos intrauterinamente al virus del Zika y hace una evaluación del neurodesarrollo con la escala de Battelle a los tres años después del nacimiento. Participaron 30 niños con una media de edad al momento de la evaluación de 37,5 (RIC: 35,7–39,2) meses. Se halló una edad equivalente en meses en las áreas: motora 25,8 (DE: 7,8), adaptativa 26,7 (DE: 5,8), comunicativa 30,2 (DE: 6,9), personal social 33,5 (DE: 8,3) y cognitiva 35,6 (DE: 5,9). Los niños presentaron retraso en el desarrollo para la edad cronológica, 25 niños presentaban retraso en una de las cinco áreas evaluadas. Una alta proporción de niños expuestos al virus del Zika durante la gestación presentaron retraso en el desarrollo, principalmente en el dominio adaptativo y motor

Regularization of the circular restricted three-body problem using 'similar' coordinate systems

The regularization of a new problem, namely the three-body problem, using 'similar' coordinate system is proposed. For this purpose we use the relation of 'similarity', which has been introduced as an equivalence relation in a previous paper (see \cite{rom11}). First we write the Hamiltonian function, the equations of motion in canonical form, and then using a generating function, we obtain the transformed equations of motion. After the coordinates transformations, we introduce the fictitious time, to regularize the equations of motion. Explicit formulas are given for the regularization in the coordinate systems centered in the more massive and the less massive star of the binary system. The 'similar' polar angle's definition is introduced, in order to analyze the regularization's geometrical transformation. The effect of Levi-Civita's transformation is described in a geometrical manner. Using the resulted regularized equations, we analyze and compare these canonical equations numerically, for the Earth-Moon binary system.Comment: 24 pages, 7 figures; Accepted for publication in Astrophysics and Space Scienc

An Approach to the Bio-Inspired Control of Self-reconfigurable Robots

Self-reconfigurable robots are robots built by modules which can move in relationship to each other. This ability of changing its physical form provides the robots a high level of adaptability and robustness. Given an initial configuration and a goal configuration of the robot, the problem of self-regulation consists on finding a sequence of module moves that will reconfigure the robot from the initial configuration to the goal configuration. In this paper, we use a bio-inspired method for studying this problem which combines a cluster-flow locomotion based on cellular automata together with a decentralized local representation of the spatial geometry based on membrane computing ideas. A promising 3D software simulation and a 2D hardware experiment are also presented.National Natural Science Foundation of China No. 6167313

Sunrise Chromospheric Infrared spectroPolarimeter (SCIP) for Sunrise III: Thermal-Vacuum Test of the SCIP Optical Unit

Ground-based and airborne instrumentation for astronomy IX (2022), Montreal, jul 17-22, 2022.--Proceedings of SPIE - The International Society for Optical Engineering vol. 12184 Article number 121842BThe Sunrise Chromospheric Infrared spectroPolarimeter (SCIP) is an instrument for the third flight of the Sunrise balloon-borne solar observatory planned for 2022. To verify the high spatial and spectral resolutions required in the balloon flight, the SCIP optical unit was subjected to a thermal-vacuum test in which the SCIP optical unit was installed in a vacuum chamber and was exposed to the thermal vacuum environment expected in the balloon flight. We verified the heater control performance and the temperature distribution in the SCIP optical unit in hot and cold conditions created by the shrouds in the vacuum chamber. We confirmed the optical performance, such as spatial and spectral resolution, and an air-to-vacuum difference of the optics by injecting the laser and white lights through a vacuum window.The Sunrise III balloon project is funded in Japan by the ISAS/JAXA Small Mission-of-Opportunity program for novel solar observations and JSPS KAKENHI Grant Number 18H05234 (PI: Y. Katsukawa). We would also thank the significant technical support given by the Advanced Technology Center (ATC), NAOJ. The Spanish contribution to Sunrise III has been supported by the Spanish Ministry of Science and Innovation through projects and ESP-2016-77548-C5-1-R and RTI2018-096886-B-C51 by "Centro de Excelencia Severo Ochoa" Program under grant SEV-2017-0709. D.O.S. also acknowledges financial support through the Ramon y Cajal fellowship. The German contribution to Sunrise III is funded by the Max Planck Foundation, the Strategic Innovations Fund of the President of the Max Planck Society (MPG), the Deutsches Zentrum fur Luft und Raumfahrt (DLR), and private donations by supporting members of the Max Planck Society, which is gratefully acknowledged.Peer reviewe

FUS-DDIT3 Prevents the Development of Adipocytic Precursors in Liposarcoma by Repressing PPARγ and C/EBPα and Activating eIF4E

FUS-DDIT3 is a chimeric protein generated by the most common chromosomal translocation t(12;16)(q13;p11) linked to liposarcomas, which are characterized by the accumulation of early adipocytic precursors. Current studies indicate that FUS-DDIT3- liposarcoma develops from uncommitted progenitors. However, the precise mechanism whereby FUS-DDIT3 contributes to the differentiation arrest remains to be elucidated. METHODOLOGY/PRINCIPAL FINDINGS: Here we have characterized the adipocyte regulatory protein network in liposarcomas of FUS-DITT3 transgenic mice and showed that PPARgamma2 and C/EBPalpha expression was altered. Consistent with in vivo data, FUS-DDIT3 MEFs and human liposarcoma cell lines showed a similar downregulation of both PPARgamma2 and C/EBPalpha expression. Complementation studies with PPARgamma but not C/EBPalpha rescued the differentiation block in committed adipocytic precursors expressing FUS-DDIT3. Our results further show that FUS-DDIT3 interferes with the control of initiation of translation by upregulation of the eukaryotic translation initiation factors eIF2 and eIF4E both in FUS-DDIT3 mice and human liposarcomas cell lines, explaining the shift towards the truncated p30 isoform of C/EBPalpha in liposarcomas. Suppression of the FUS-DDIT3 transgene did rescue this adipocyte differentiation block. Moreover, eIF4E was also strongly upregulated in normal adipose tissue of FUS-DDIT3 transgenic mice, suggesting that overexpression of eIF4E may be a primary event in the initiation of liposarcomas. Reporter assays showed FUS-DDIT3 is involved in the upregulation of eIF4E in liposarcomas and that both domains of the fusion protein are required for affecting eIF4E expression. CONCLUSIONS/SIGNIFICANCE: Taken together, this study provides evidence of the molecular mechanisms involve in the disruption of normal adipocyte differentiation program in liposarcoma harbouring the chimeric gene FUS-DDIT3.Research in ISG group is supported partially by FEDER and by MEC (SAF2006-03726), Junta de Castilla y León (CSI03A05), FIS (PI050087, PI050116), Fundación de Investigación MMA, Federación de Cajas de Ahorro Castilla y León (I Convocatoria de Ayudas para Proyectos de Investigación Biosanitaria con Células Madre), CDTEAM project (CENIT-Ingenio 2010) and MEC Consolider-Ingenio 2010 (Ref. CSD2007-0017).Research in ISG group is supported partially by FEDER and by MEC (SAF2006-03726 and PETRI N° 95-0913.OP), Junta de Castilla y León (CSI03A05), FIS (PI050087, PI050116), Fundación de Investigación MMA, Federación de Cajas de Ahorro Castilla y León (I Convocatoria de Ayudas para Proyectos de Investigación Biosanitaria con Células Madre), CDTEAM project (CENIT-Ingenio 2010) and MEC Consolider-Ingenio 2010 (Ref. CSD2007-0017). MSM is supported by the Ramon y Cajal Scientific Spanish Program, Fondo Investigacion Sanitaria (FIS PI04-1271), Junta de Castilla y León (SA085A06) and Fundación Manuel Solorzano, University of Salamanca.Peer reviewe

Measurements of fiducial and differential cross sections for Higgs boson production in the diphoton decay channel at s√=8 TeV with ATLAS

Measurements of fiducial and differential cross sections are presented for Higgs boson production in proton-proton collisions at a centre-of-mass energy of s√=8 TeV. The analysis is performed in the H → γγ decay channel using 20.3 fb−1 of data recorded by the ATLAS experiment at the CERN Large Hadron Collider. The signal is extracted using a fit to the diphoton invariant mass spectrum assuming that the width of the resonance is much smaller than the experimental resolution. The signal yields are corrected for the effects of detector inefficiency and resolution. The pp → H → γγ fiducial cross section is measured to be 43.2 ±9.4(stat.) − 2.9 + 3.2 (syst.) ±1.2(lumi)fb for a Higgs boson of mass 125.4GeV decaying to two isolated photons that have transverse momentum greater than 35% and 25% of the diphoton invariant mass and each with absolute pseudorapidity less than 2.37. Four additional fiducial cross sections and two cross-section limits are presented in phase space regions that test the theoretical modelling of different Higgs boson production mechanisms, or are sensitive to physics beyond the Standard Model. Differential cross sections are also presented, as a function of variables related to the diphoton kinematics and the jet activity produced in the Higgs boson events. The observed spectra are statistically limited but broadly in line with the theoretical expectations

Search for squarks and gluinos in events with isolated leptons, jets and missing transverse momentum at s√=8 TeV with the ATLAS detector

The results of a search for supersymmetry in final states containing at least one isolated lepton (electron or muon), jets and large missing transverse momentum with the ATLAS detector at the Large Hadron Collider are reported. The search is based on proton-proton collision data at a centre-of-mass energy s√=8 TeV collected in 2012, corresponding to an integrated luminosity of 20 fb−1. No significant excess above the Standard Model expectation is observed. Limits are set on supersymmetric particle masses for various supersymmetric models. Depending on the model, the search excludes gluino masses up to 1.32 TeV and squark masses up to 840 GeV. Limits are also set on the parameters of a minimal universal extra dimension model, excluding a compactification radius of 1/R c = 950 GeV for a cut-off scale times radius (ΛR c) of approximately 30

Evidence for the Higgs-boson Yukawa coupling to tau leptons with the ATLAS detector

Results of a search for H → τ τ decays are presented, based on the full set of proton-proton collision data recorded by the ATLAS experiment at the LHC during 2011 and 2012. The data correspond to integrated luminosities of 4.5 fb−1 and 20.3 fb−1 at centre-of-mass energies of √s = 7 TeV and √s = 8 TeV respectively. All combinations of leptonic (τ → `νν¯ with ` = e, µ) and hadronic (τ → hadrons ν) tau decays are considered. An excess of events over the expected background from other Standard Model processes is found with an observed (expected) significance of 4.5 (3.4) standard deviations. This excess provides evidence for the direct coupling of the recently discovered Higgs boson to fermions. The measured signal strength, normalised to the Standard Model expectation, of µ = 1.43 +0.43 −0.37 is consistent with the predicted Yukawa coupling strength in the Standard Model