Moderne huisvesting melkvee

Brochure met praktische adviezen om de melkveehouder op een overzichtelijke en prikkelende manier te informeren over een goede huisvesting van melkvee waarmee het welzijn van de koeien verbeterd kan worden. Er wordt nader ingegaan op regelgeving en subsidies, erfinrichting, de uitvoering van de ligboxenstal, het melken en stalsysteme

Three-dimensional flow instability in a lid-driven isosceles triangular cavity

Linear three-dimensional modal instability of steady laminar two-dimensional states developing in a lid-driven cavity of isosceles triangular cross-section is investigated theoretically and experimentally for the case in which the equal sides form a rectangular corner. An asymmetric steady two-dimensional motion is driven by the steady motion of one of the equal sides. If the side moves away from the rectangular corner, a stationary three-dimensional instability is found. If the motion is directed towards the corner, the instability is oscillatory. The respective critical Reynolds numbers are identified both theoretically and experimentally. The neutral curves pertinent to the two configurations and the properties of the respective leading eigenmodes are documented and analogies to instabilities in rectangular lid-driven cavities are discussed

Borging van melkwachten = Guarantee of milk guards

The adjustments of milk guards were evaluated. The ‘non loading’ alarms don’t need changes. Dairy farmers want to be alarmed better, but have to act on alarm

When B cells break bad:development of pathogenic B cells in Sjögren’s syndrome

Primary Sjögren's syndrome (pSS) is often considered a B cell-mediated disease, yet the precise role of B cells in the pathogenesis is not fully understood. This is exemplified by the failure of multiple clinical trials directed at B cell depletion or inhibition. To date, most prognostic markers for severe disease outcomes are autoantibodies, but the underlying mechanisms by which B cells drive diverse disease presentations in pSS likely extend beyond autoantibody production. Here we outline an expanded role of B cells in disease pathogenesis drawing on examples from animal models of SS, and from other autoimmune diseases that share similar clinical or immunological abnormalities. We focus on recent findings from the detailed analysis of pathogenic B cells in patients with pSS to propose strategies for patient stratification to improve clinical trial outcomes. We conclude that an integrated cellular, molecular and genetic analysis of patients with pSS will reveal the underlying pathogenic mechanisms and guide precision medicine.J.H. Reed, G.M. Verstappen, M. Rischmueller, V.L. Bryan