Probing non-Gaussianities in the CMB on an incomplete sky using surrogates

We demonstrate the feasibility to generate surrogates by Fourier-based methods for an incomplete data set. This is performed for the case of a CMB analysis, where astrophysical foreground emission, mainly present in the Galactic plane, is a major challenge. The shuffling of the Fourier phases for generating surrogates is now enabled by transforming the spherical harmonics into a new set of basis functions that are orthonormal on the cut sky. The results show that non-Gaussianities and hemispherical asymmetries in the CMB as identified in several former investigations, can still be detected even when the complete Galactic plane (|b| < 30{\deg}) is removed. We conclude that the Galactic plane cannot be the dominant source for these anomalies. The results point towards a violation of statistical isotropy.Comment: 9 pages, 13 figures, accepted by Physical Review

Localization of Human RNase Z Isoforms: Dual Nuclear/Mitochondrial Targeting of the ELAC2 Gene Product by Alternative Translation Initiation

RNase Z is an endonuclease responsible for the removal of 3′ extensions from tRNA precursors, an essential step in tRNA biogenesis. Human cells contain a long form (RNase ZL) encoded by ELAC2, and a short form (RNase ZS; ELAC1). We studied their subcellular localization by expression of proteins fused to green fluorescent protein. RNase ZS was found in the cytosol, whereas RNase ZL localized to the nucleus and mitochondria. We show that alternative translation initiation is responsible for the dual targeting of RNase ZL. Due to the unfavorable context of the first AUG of ELAC2, translation apparently also starts from the second AUG, whereby the mitochondrial targeting sequence is lost and the protein is instead routed to the nucleus. Our data suggest that RNase ZL is the enzyme involved in both, nuclear and mitochondrial tRNA 3′ end maturation

Search for non-Gaussianities in the WMAP data with the Scaling Index Method

In the recent years, non-Gaussianity and statistical isotropy of the Cosmic Microwave Background (CMB) was investigated with various statistical measures, first and foremost by means of the measurements of the WMAP satellite. In this Review, we focus on the analyses that were accomplished with a measure of local type, the so-called Scaling Index Method (SIM). The SIM is able to detect structural characteristics of a given data set, and has proven to be highly valuable in CMB analysis. It was used for comparing the data set with simulations as well as surrogates, which are full sky maps generated by randomisation of previously selected features of the original map. During these investigations, strong evidence for non-Gaussianities as well as asymmetries and local features could be detected. In combination with the surrogates approach, the SIM detected the highest significances for non-Gaussianity to date.Comment: 19 pages, 15 figures, Review Article, Accepted for publication in Advances in Astronom

Magnetic Characterization of a Superconducting Transverse Gradient Undulator for Compact Laser Wakefield Accelerator-Driven FELs

A transverse gradient undulator (TGU) is a key component compensating for the relatively large energy spread of Laser Wakefield Accelerator (LWFA)-generated electron beams for realizing a compact Free Electron Laser (FEL). A superconducting TGU with 40 periods has been fabricated at the Karlsruhe Institute of Technology (KIT). In this contribution, we report that the superconducting TGU has been commissioned with nominal operational parameters at an off-line test bench. An experimental set-up for mapping the magnetic field on a two-dimensional grid in the TGU gap has been employed for the magnetic characterization. We show the first preliminary results of these measurements showing the longitudinal quality, the transverse gradient and the transient behaviour of the superconducting TGU field