Kommunale tiltak i psykisk helsearbeid 2011. Årsverksstatistikk og analyser av kommunal variasjon

Rapport med analyser og deskriptive framstillinger av årsverkinnsatsen i psykisk helsearbeid i kommunene 2007-2011.Rapporten fokuserer på årsverksinnsats både i kommuner (psykisk helsearbeid) og i spesialisthelsetjenesten (psykisk helsevern). Tallene viser stor geografisk variasjon. Rapporten ser også på fastlegenes rolle i psykisk helsearbeid. Hovedutfordringer i kommunene utgjør økt etterspørsel, sykere pasienter utskrevet fra spesialisthelsetjenesten, vanskeligheter med å gi et tilbud av god nok faglig kvalitet, utfordringer i samarbeidet med spesialisthelsetjenesten og mangel på kompetanse.&nbsp

Influence of urban land cover changes and climate change for the exposure of European cities to flooding during high-intensity precipitation

The extent and location of impervious surfaces within urban areas due to past and present city development strongly affects the amount and velocity of run-off during high-intensity rainfall and consequently influences the exposure of cities towards flooding. The frequency and intensity of extreme rainfall are expected to increase in many places due to climate change and thus further exacerbate the risk of pluvial flooding. This paper presents a combined hydrological-hydrodynamic modelling and remote sensing approach suitable for examining the susceptibility of European cities to pluvial flooding owing to recent changes in urban land cover, under present and future climatic conditions. Estimated changes in impervious urban surfaces based on Landsat satellite imagery covering the period 1984–2014 are combined with regionally downscaled estimates of current and expected future rainfall extremes to enable 2-D overland flow simulations and flood hazard assessments. The methodology is evaluated for the Danish city of Odense. Results suggest that the past 30 years of urban development alone has increased the city's exposure to pluvial flooding by 6% for 10-year rainfall up to 26% for 100-year rainfall. Corresponding estimates for RCP4.5 and RCP8.5 climate change scenarios (2071–2100) are in the order of 40 and 100%, indicating that land cover changes within cities can play a central role for the cities' exposure to flooding and conversely also for their adaptation to a changed climate

Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1

The treatment of Human African Trypanosomiasis remains a major unmet health need in sub-Saharan Africa. Approaches involving new molecular targets are important and pteridine reductase 1 (PTR1), an enzyme that reduces dihydrobiopterin in Trypanosoma spp. has been identified as a candidate target and it has been shown previously that substituted pyrrolo[2,3-d]pyrimidines are inhibitors of PTR1 from T. brucei (J. Med. Chem. 2010, 53, 221-229). In this study, 61 new pyrrolo[2,3-d]pyrimidines have been prepared, designed with input from new crystal structures of 23 of these compounds complexed with PTR1, and evaluated in screens for enzyme inhibitory activity against PTR1 and in vitro antitrypanosomal activity. 8 compounds were sufficiently active in both screens to take forward to in vivo evaluation. Thus although evidence for trypanocidal activity in a stage I disease model in mice was obtained, the compounds were too toxic to mice for further development

Chronic administration of hydrolysed pine nut oil to mice improves insulin sensitivity and glucose tolerance and increases energy expenditure via a free fatty acid receptor 4-dependent mechanism

A healthy diet is at the forefront of measures to prevent type 2 diabetes. Certain vegetable and fish oils, such as pine nut oil (PNO), have been demonstrated to ameliorate the adverse metabolic effects of a high-fat diet. The present study study investigates the involvement of the free fatty acid receptors 1 (FFAR1) and 4 (FFAR4) in the chronic activity of hydrolysed PNO (hPNO) on high-fat diet-induced obesity and insulin resistance. Male C57BL/6J wild-type, FFAR1 knockout (-/-) and FFAR4-/- mice were placed on 60% high-fat diet for 3 months. Mice were then dosed hPNO for 24 days, during which time body composition, energy intake and expenditure, glucose tolerance and fasting plasma insulin, leptin and adiponectin were measured. hPNO improved glucose tolerance and decreased plasma insulin in the wild-type and FFAR1-/- mice, but not the FFAR4-/- mice. hPNO also decreased high-fat diet-induced bodyweight gain and fat mass, whilst increasing energy expenditure and plasma adiponectin. None of these effects on energy balance were statistically significant in FFAR4-/- mice but it was not shown that they were significantly less than in wild-type mice. In conclusion, chronic hPNO supplementation reduces the metabolically detrimental effects of high-fat diet on obesity and insulin resistance in a manner that is dependent on the presence of FFAR4