The non-locality of n noisy Popescu-Rohrlich boxes

We quantify the amount of non-locality contained in n noisy versions of so-called Popescu-Rohrlich boxes (PRBs), i.e., bipartite systems violating the CHSH Bell inequality maximally. Following the approach by Elitzur, Popescu, and Rohrlich, we measure the amount of non-locality of a system by representing it as a convex combination of a local behaviour, with maximal possible weight, and a non-signalling system. We show that the local part of n systems, each of which approximates a PRB with probability $1-\epsilon$, is of order $\Theta(\epsilon^{\lceil n/2\rceil})$ in the isotropic, and equal to $(3\epsilon)^n$ in the maximally biased case.Comment: 14 pages, v2: published versio

Accumulating Particles at the Boundaries of a Laminar Flow

The accumulation of small particles is analyzed in stationary flows through channels of variable width at small Reynolds number. The combined influence of pressure, viscous drag and thermal fluctuations is described by means of a Fokker-Planck equation for the particle density. It is shown that in the limit of vanishing particle size a uniform particle distribution is always approached in the long time limit. For extended spherical particles, conditions are specified that lead to inhomogeneous densities and consequently to particle accumulation and depletion. Hereby the boundary conditions for the particle density play a decisive role: The centers of spherical particles must keep the minimal distance of their radius from the fluid boundaries. The normal components of the forces acting on the sphere then may assume finite values which are diffusively transported into the bulk of the fluid.Comment: final version, accepted by Physica

Brownian motors

In systems possessing a spatial or dynamical symmetry breaking thermal Brownian motion combined with unbiased, non-equilibrium noise gives rise to a channelling of chance that can be used to exercise control over systems at the micro- and even on the nano-scale. This theme is known as ``Brownian motor'' concept. The constructive role of (the generally overdamped) Brownian motion is exemplified for a noise-induced transport of particles within various set-ups. We first present the working principles and characteristics with a proof-of-principle device, a diffusive temperature Brownian motor. Next, we consider very recent applications based on the phenomenon of signal mixing. The latter is particularly simple to implement experimentally in order to optimize and selectively control a rich variety of directed transport behaviors. The subtleties and also the potential for Brownian motors operating in the quantum regime are outlined and some state-of-the-art applications, together with future roadways, are presented.Comment: 20 pages, 9 figures (slightly changed version

Longitudinal analysis of caloric requirements in critically ill trauma patients: a retrospective cohort study.

PURPOSE Nutrition is of paramount importance in critically ill trauma patients. However, adequate supply is difficult to achieve, as caloric requirements are unknown. This study investigated caloric requirements over time, based on indirect calorimetry, in critically ill trauma patients. METHODS Retrospective cohort study at a tertiary trauma center including critically ill trauma patients who underwent indirect calorimetry 2012-2019. Caloric requirements were assessed as resting energy expenditure (REE) during the intensive care unit stay up to 28 days and analyzed in patient-clustered linear regression analysis. RESULTS A total of 129 patients were included. Median REE per day was 2376 kcal. The caloric intake did not meet REE at any time with a median daily deficit of 1167 kcal. In univariable analysis, ISS was not significantly associated with REE over time (RC 0.03, p = 0.600). Multivariable analysis revealed a significant REE increase (RC 0.62, p < 0.001) and subsequent decrease (RC - 0.03, p < 0.001) over time. Age < 65 years (RC 2.07, p = 0.018), male sex (RC 4.38, p < 0.001), and BMI ≥ 35 kg/m2 (RC 6.94, p < 0.001) were identified as independent predictors for higher REE over time. Severe head trauma was associated with lower REE over time (RC - 2.10, p = 0.030). CONCLUSION In critically ill trauma patients, caloric requirements significantly increased and subsequently decreased over time. Younger age, male sex and higher BMI were identified as independent predictors for higher caloric requirements, whereas severe head trauma was associated with lower caloric requirements over time. These results support the use of IC and will help to adjust nutritional support in critically ill trauma patients

Incidence of low central venous oxygen saturation during unplanned admissions in a multidisciplinary intensive care unit: an observational study

INTRODUCTION: It has been shown that early central venous oxygen saturation (ScvO2)-guided optimization of hemodynamics can improve outcome in septic patients. The early ScvO2 profile of other patient groups is unknown. The aim of this study was to characterize unplanned admissions in a multidisciplinary intensive care unit (ICU) with respect to ScvO2 and outcome. METHODS: Ninety-eight consecutive unplanned admissions to a multidisciplinary ICU (median age 63 [range 19 to 83] years, median Simplified Acute Physiology Score [SAPS II] 43 [range 11 to 92]) with a clinical indication for a central venous catheter were included in the study. ScvO2 was assessed at ICU arrival and six hours later but was not used to guide treatment. Length of stay in ICU (LOSICU) and in hospital (LOShospital) and 28-day mortality were recorded. RESULTS: ScvO2 was 70% +/- 12% (mean +/- standard deviation) at admission and 71% +/- 10% six hours later (p = 0.484). Overall 28-day mortality was 18%, LOSICU was 3 (1 to 28) days, and LOShospital was 19 (1 to 28) days. Patients with an ScvO2 of less than 60% at admission had higher mortality than patients with an ScvO2 of more than 60% (29% versus 17%, p < 0.05). Changes in ScvO2 during the first six hours were not predictive of LOSICU, LOShospital, or mortality. CONCLUSION: Low ScvO2 in unplanned admissions and high SAPS II are associated with increased mortality. Standard ICU treatment increased ScvO2 in patients with a low admission ScvO2, but the increase was not associated with LOSICU or LOShospital

Typical local measurements in generalised probabilistic theories: emergence of quantum bipartite correlations

What singles out quantum mechanics as the fundamental theory of Nature? Here we study local measurements in generalised probabilistic theories (GPTs) and investigate how observational limitations affect the production of correlations. We find that if only a subset of typical local measurements can be made then all the bipartite correlations produced in a GPT can be simulated to a high degree of accuracy by quantum mechanics. Our result makes use of a generalisation of Dvoretzky's theorem for GPTs. The tripartite correlations can go beyond those exhibited by quantum mechanics, however.Comment: 5 pages, 1 figure v2: more details in the proof of the main resul

Spin-Orbit Based Coherent Spin Ratchets

The concept of ratchets, driven asymmetric periodic structures giving rise to directed particle flow, has recently been generalized to a quantum ratchet mechanism for spin currents mediated through spin-orbit interaction. Here we consider such systems in the coherent mesoscopic regime and generalize the proposal of a minimal spin ratchet model based on a non-interacting clean quantum wire with two transverse channels by including disorder and by self-consistently treating the charge redistribution in the nonlinear (adiabatic) ac-driving regime. Our Keldysh-Green function based quantum transport simulations show that the spin ratchet mechanism is robust and prevails for disordered, though non-diffusive, mesoscopic structures. Extending the two-channel to the multi-channel case does not increase the net ratchet spin current efficiency but, remarkably, yields a dc spin transmission increasing linearly with channel number.Comment: 23 pages, 7 figures; to be published in Chemical Physic

Nebulized Bacteriophages for Prophylaxis of Experimental Ventilator-Associated Pneumonia Due to Methicillin-Resistant Staphylococcus aureus.

OBJECTIVES There is a need for alternative strategies to combat and prevent antibiotic-resistant bacterial infections. Here, we assessed the potential for bacteriophage prophylaxis in the context of experimental ventilator-associated pneumonia due to methicillin-resistant Staphylococcus aureus in rats. DESIGN Nebulized phages (aerophages) were delivered to the lungs of rats using a modified vibrating mesh aerosol drug delivery system. Animals were intubated and ventilated for 4 hours, at which point they were infected with methicillin-resistant S. aureus strain AW7 via the endotracheal tube, extubated, and then monitored for 96 hours. SETTING Ventilator-associated pneumonia. SUBJECTS Male Wistar rats. INTERVENTIONS A single application of aerophages prior to ventilation at one of two concentrations (~1010 plaque forming units/mL or ~1011 plaque forming units/mL). MEASUREMENTS AND MAIN RESULTS 1) Animal survival at 96 hours, 2) enumeration of bacteria and phages in the lungs and spleen, and 3) lung tissue histopathology. Animals that received aerophages prior to ventilation and methicillin-resistant S. aureus challenge showed a higher survival rate compared with untreated controls (60% for animals that received 3 × 10 plaque forming units; 70% for animals that received 3 × 10 plaque forming units; 0% for controls; p < 0.01 for each treatment versus untreated). Surviving animals that received aerophage prophylaxis had fewer methicillin-resistant S. aureus in the lungs compared with untreated control animals that succumbed to pneumonia (1.6 × 10 colony forming units/g vs 8.0 × 10; p < 0.01). CONCLUSIONS Prophylactically administered nebulized bacteriophages reduced lung bacterial burdens and improved survival of methicillin-resistant S. aureus infected rats, underscoring its potential in the context of ventilator-associated pneumonia