HLA-DQA1*05 carriage associated with development of anti-drug antibodies to infliximab and adalimumab in patients with Crohn's Disease

Anti-tumor necrosis factor (anti-TNF) therapies are the most widely used biologic drugs for treating immune-mediated diseases, but repeated administration can induce the formation of anti-drug antibodies. The ability to identify patients at increased risk for development of anti-drug antibodies would facilitate selection of therapy and use of preventative strategies.This article is freely available via Open Access. Click on Publisher URL to access the full-text

Escaping the Everyday? Women's Clothing on Holiday

Going abroad on holiday is now a common experience for people in the UK with nearly 39 million such visits being made in 1997 (GSS). Whether holidays represent a real escape from everyday routines or merely the illusion of escape is hotly contested in the wide-ranging academic literature on this topic. The authors of this paper draw on previous and new research to argue that holidays do represent a ʻnon-everydayʼ experience but one which can only be understood by seeing it in the context of the ʻchained activitiesʼ of everyday life. Further, to understand the ʻnon-everydayʼ experience, we need to develop a more complex, dynamic and fluid definition of the 'everyday'. The authors carried out research with 20 women as they packed to go abroad on holiday and explored with them their aspirations for their holidays and found that they hoped their choice of holiday clothes would help them realise their ʻholiday selfʼ. It became evident that holiday time is perceived as distinct and different from the normal routines of everyday life. However, the boundaries between everyday and non-everyday are fuzzy with each having the capacity to inform and potentially transform the other

Escaping the everyday? Women's clothing on holiday

Includes bibliographical referencesAvailable from British Library Document Supply Centre- DSC:3830. 809999(no 6) / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo