Retinoprotective effects of non-selective imidazoline receptor agonists

Current drug therapy of ophtalmic diseases associated with retinal ischemia is not always successful enough that ensures the relevance of the search of new effective drug

Perfection of the mechanism of planning of innovative activities based on the system-transdisciplinary approach

The possibility of applying transdisciplinary system methodology in the process of developing plans for the innovative development of business entities has been considered. The use of a transdisciplinary systematic approach to innovation planning allows you to use new methodological planning tools, strengthen the systematic nature of planned activities, more clearly define their content and sequence.Various variants of the classification of scientific approaches according to the criterion of the degree of completeness of cognition of the surrounding world have been analysed, the basic transdisciplinary methodological approaches according to the content criteria and possibilities have been compared, such as: the theory of autopoiesis, the theory of chaos and complexity, the theory of fractals, the theory of turbulence and the theory of economic genetics.An important factor in the proposed methodology is the use of the evolutionary property of the development of organizational systems in combination with the possibility of revolutionary transformations at certain stages of development that determine the susceptibility of the organizational system to innovations. In the process of planning innovations, it is only possible to take into account these features of the development of organizational systems using a systemic transdisciplinary methodology.In the process of research, a transdisciplinary tool such as multiplex has been proposed for use, allowing us to determine the duration of the “internal” periods of development of the organizational system and, consequently, increase the validity of planned measures for the implementation of innovations. The use of this tool in the planning process has allowed us to find an approach to determining the duration of the periods of the various stages of the innovation process, which can in future provide an opportunity to effectively distribute the resources of an economic entity over time. At the same time, special attention in the process of planning investments in the innovation process has been paid to the practice of venture and business angel financing, the positive performance of which has been proved by the example of the United States

Static conductivity of charged domain wall in uniaxial ferroelectric-semiconductors

Using Landau-Ginzburg-Devonshire theory we calculated numerically the static conductivity of both inclined and counter domain walls in the uniaxial ferroelectrics-semiconductors of n-type. We used the effective mass approximation for the electron and holes density of states, which is valid at arbitrary distance from the domain wall. Due to the electrons accumulation, the static conductivity drastically increases at the inclined head-to-head wall by 1 order of magnitude for small incline angles theta pi/40 by up 3 orders of magnitude for the counter domain wall (theta=pi/2). Two separate regions of the space charge accumulation exist across an inclined tail-to-tail wall: the thin region in the immediate vicinity of the wall with accumulated mobile holes and the much wider region with ionized donors. The conductivity across the tail-to-tail wall is at least an order of magnitude smaller than the one of the head-to-head wall due to the low mobility of holes, which are improper carries. The results are in qualitative agreement with recent experimental data for LiNbO3 doped with MgO.Comment: 20 pages, 6 figures, 1 appendi

Genotypic variability of Pinus sylvestris L. on the drought-resistance attribute

There was an increase and intensification of droughts in connection with global climate change in recent decades. Not all plant organisms are able to adapt to changing environmental conditions. Therefore, the question of stressresistant (drought-resistant) genotypes selection for breeding is quite urgent. This problem also concerns forest tree plants, including Scots pine, which is one of the main foresters in the Voronezh region. The results of vegetative and generative sphere analysis of individual Scotch pine trees with the help of biotechnology, molecular-genetic and cytogenetic method are given in this study. The possibility of applying the tissue culture method in vitro for testing initial plants for stress resistance, including drought resistance, is explained by the interconnection of cells, tissues and the whole plant properties. It is shown that the cytogenetic characteristics of the seed progeny and the indicators of callusogenic reactions do not always coincide in different genotypes: in some cases energy resources are spent on ontogeny protection, while, in other cases, to reproductive function maintain. There are trees, in which the state the generative sphere in arid years is at the level of optimal years, and their callus cultures reaction remains unchanged even under simulated conditions of drought. Based on the results obtained for the selection of Scots pine drought-resistant genotypes we suggest applying a system of criteria characterizing both the ability of the vegetative sphere to survive in drought conditions on the basis of the tissue culture method in vitro (callus tissue formation speed, its viability, frequency of callusogenesis), and the state of the generative sphere with the help of cytogenetic analysis of seed progeny (frequency of mitosis pathologies, the proportion of cells with micronuclei, mitotic activity). The expediency of applying the biotechnological approach was proved by analysis of the gene expression level of stress proteins: the level of AbaH gene expression correlates greatly with the indicator of the viability of callus cultures, including ones on a nutrient medium with an additional stress agent (NaCl). Trees that can be assigned to drought-resistant ones, according to the results of the analysis, should be recommended for use in breeding

Ultra-High Energy Cosmic Ray production in the polar cap regions of black hole magnetospheres

We develop a model of ultra-high energy cosmic ray (UHECR) production via acceleration in a rotation-induced electric field in vacuum gaps in the magnetospheres of supermassive black holes (BH). We show that if the poloidal magnetic field near the BH horizon is misaligned with the BH rotation axis, charged particles, which initially spiral into the BH hole along the equatorial plane, penetrate into the regions above the BH "polar caps" and are ejected with high energies to infinity. We show that in such a model acceleration of protons near a BH of typical mass 3e8 solar masses is possible only if the magnetic field is almost aligned with the BH rotation axis. We find that the power of anisotropic electromagnetic emission from an UHECR source near a supermassive BH should be at least 10-100 times larger then UHECR power of the source. This implies that if the number of UHECR sources within the 100 Mpc sphere is ~100, the power of electromagnetic emission which accompanies proton acceleration in each source, $10^{42-43}$ erg/s, is comparable to the typical luminosities of active galactic nuclei (AGN) in the local Universe. We also explore the acceleration of heavy nuclei, for which the constraints on the electromagnetic luminosity and on the alignment of magnetic field in the gap are relaxed

Информационные площадки для профессионального наукометрического сообщества: обзор работы Третьей научной конференции «Наукометрия, библиометрия, открытые данные и публикации в науке»

The authors review the papers delivered at the Third Scientific Conference “Scientometrics, bibliometrics, open data and publications in science” held within the framework of the Sixth World Professional Forum “The Book. Culture. Education. Innovations” (“Crimea–2021”) (June 5–13, 2021, Republic of Crimea, Russian Federation). The Conference key topics discussed at its three sessions were: trends in sci-tech development, scientometric studies of scientific periodicals, as well as case studies and regional research through scientometric tools. The hot topics in Russian scientometrics are specified, including applied studies of bibliometric analysis for assessment of researchers, organizations, countries and journals, as well as of science migration streams, and theoretical development of new indicators of or search for scientometric frontiers. Within the practical part of the conference, The Basics of Bibliometrics crash course was offered to the participants. It comprised essential knowledge, competences and skills of work with science citation databases. The need for the more intensive exchange of knowledge within the Russian emerging scientometrics community to expand competences, to strengthen communication between those assessing and being assessed is substantiated. These would contribute not only scientometrics but the Russian science on the whole.Обзор докладов, представленных на Третьей научной конференции «Наукометрия, библиометрия, открытые данные и публикации в науке», прошедшей в рамках Шестого международного профессионального форума «Книга. Культура. Образование. Инновации» («Крым–2021») (5–13 июня 2021 г., г. Судак, Республика Крым, Российская Федерация). Ключевые тематики конференции на трёх заседаниях: тренды научно-технологического развития, наукометрические исследования, связанные с научной периодикой, а также тематические и региональные исследования, выполненные с применением наукометрии. Показаны актуальные направления современной наукометрии в России, включая как прикладные исследования по анализу библиометрических индикаторов для оценки учёных, организаций, стран или журналов, оценки научных миграционных потоков, так и теоретические разработки новых индикаторов или поиск границ применения наукометрии. Практическая часть конференции – экспресс-курс «Основы библиометрии», целью которого являлось предоставление слушателям комплекса знаний, компетенций и умений, необходимых для работы с базами данных научного цитирования. Подчёркнута необходимость более интенсивного обмена знаниями в формирующемся российском наукометрическом сообществе, что будет способствовать расширению компетенций участников, налаживанию недостаточных на текущий момент коммуникаций между оценивающими и оцениваемыми, что в итоге поможет решить многие проблемы не только современной наукометрии, но и российской науки в целом

Field induced single ion magnet based on a quasi octahedral Co ii complex with mixed sulfur oxygen coordination environment

Synthesis and characterization of structure and magnetic properties of the quasi octahedral complex pipH2 [Co TDA 2] 2H2O I , pipH22 piperazine dication, TDA2 amp; 8722; thiodiacetic anion are described. X ray diffraction studies reveal the first coordination sphere of the Co II ion, consisting of two chelating tridentate TDA ligands with a mixed sulfur oxygen strongly elongated octahedral coordination environment. SQUID magnetometry, frequency domain Fourier transform FD FT THz EPR spectroscopy, and high level ab initio SA CASSCF NEVPT2 quantum chemical calculations reveal a strong easy plane type magnetic anisotropy D amp; 8776; 54 cm amp; 8722;1 of complex I. The complex shows field induced slow relaxation of magnetization at an applied DC field of 1000 O

The ART-XC telescope on board the SRG observatory

ART-XC (Astronomical Roentgen Telescope - X-ray Concentrator) is the hard X-ray instrument with grazing incidence imaging optics on board the Spektr-Roentgen-Gamma (SRG) observatory. The SRG observatory is the flagship astrophysical mission of the Russian Federal Space Program, which was successively launched into orbit around the second Lagrangian point (L2) of the Earth-Sun system with a Proton rocket from the Baikonur cosmodrome on 13 July 2019. The ART-XC telescope will provide the first ever true imaging all-sky survey performed with grazing incidence optics in the 4-30 keV energy band and will obtain the deepest and sharpest map of the sky in the energy range of 4-12 keV. Observations performed during the early calibration and performance verification phase as well as during the on-going all-sky survey that started on 12 Dec. 2019 have demonstrated that the in-flight characteristics of the ART-XC telescope are very close to expectations based on the results of ground calibrations. Upon completion of its 4-year all-sky survey, ART-XC is expected to detect ~5000 sources (~3000 active galactic nuclei, including heavily obscured ones, several hundred clusters of galaxies, ~1000 cataclysmic variables and other Galactic sources), and to provide a high-quality map of the Galactic background emission in the 4-12 keV energy band. ART-XC is also well suited for discovering transient X-ray sources. In this paper, we describe the telescope, results of its ground calibrations, major aspects of the mission, the in-flight performance of ART-XC and first scientific results.Comment: 19 pages, 30 figures, accepted for publication in Astronomy and Astrophysic

Conference of Soviet and American Jurists on the Law of the Sea and the Protection of the Marine Environment

Included in the papers for the Conference of Soviet and American Jurists on the Law of the Sea and the Protection of the Marine Environment: Introduction by Milton Katz and Richard R. Baxter, p. 1 Freedom of Scientific Research in the World Ocean by A.F. Vysotsky, p. 7 The International Law of Scientific Research in the Oceans by Richard R. Baxter, p. 27 Responsibility and Liability for Harm to the Marine Environment by Robert E. Stein, p. 41 Liability for Marine Environment Pollution Damage in Contemporary International Sea Law by A. L. Makovsky, p. 59 Protection of the Marine Environment from Pollution by Richard A. Frank, p. 73 The Freedom of Navigation and the Problem of Pollution of the Marine Environment by V. A. Kiselev, p. 93 The Freedom of Navigation Under International Law by William E. Butler, p. 107 International Fisheries Management Without Global Agreement: United States Policies and Their Impact on the Soviet Union by H. Gary Knight, p. 119 Some Biological Background for International Legal Acts on Rational Utilization of the Living Resources of the World Ocean by P. A. Moiseev, p. 143 An International Regime for the Seabed Beyond National Jurisdiction by Thomas M. Franck, p. 151 Settlement of Disputes Under the Law of Ocean Use, with Particular Reference to Environmental Protection by John Lawrence Hargrove, p. 18

The eROSITA X-ray telescope on SRG

eROSITA (extended ROentgen Survey with an Imaging Telescope Array) is the primary instrument on the Spectrum-Roentgen-Gamma (SRG) mission, which was successfully launched on July 13, 2019, from the Baikonour cosmodrome. After the commissioning of the instrument and a subsequent calibration and performance verification phase, eROSITA started a survey of the entire sky on December 13, 2019. By the end of 2023, eight complete scans of the celestial sphere will have been performed, each lasting six months. At the end of this program, the eROSITA all-sky survey in the soft X-ray band (0.2-2.3 keV) will be about 25 times more sensitive than the ROSAT All-Sky Survey, while in the hard band (2.3-8 keV) it will provide the first ever true imaging survey of the sky. The eROSITA design driving science is the detection of large samples of galaxy clusters up to redshifts z > 1 in order to study the large-scale structure of the universe and test cosmological models including Dark Energy. In addition, eROSITA is expected to yield a sample of a few million AGNs, including obscured objects, revolutionizing our view of the evolution of supermassive black holes. The survey will also provide new insights into a wide range of astrophysical phenomena, including X-ray binaries, active stars, and diffuse emission within the Galaxy. Results from early observations, some of which are presented here, confirm that the performance of the instrument is able to fulfil its scientific promise. With this paper, we aim to give a concise description of the instrument, its performance as measured on ground, its operation in space, and also the first results from in-orbit measurements