Humanitarian meaning of university professional education

In the 20th century, the university faced a principally new type of cultural development and there was a necessity of transformation to get adapted to new conditions. Change of cultural epochs lead to a change in criteria and principles conditioning the university education system. Largely it affected “externally invisible and inaudible” factor, “the fluid of spiritual life” of the university, “human immaterial sub-basis” of its existence (Jaspers, 2006) - its humanitarian meaning. This can nowadays indicate that existence of the university is challenged

Clinical considerations and key issues in the management of patients with Erdheim-Chester Disease: A seven case series

Background: Erdheim-Chester Disease (ECD), a non Langerhans' cell histiocytosis of orphan nature and propensity for multi-systemic presentations, comprises an intricate medical challenge in terms of diagnosis, treatment and complication management. Objectives: The objectives are to report the clinical, radiological and pathological characteristics, as well as cardinal therapeutic approaches to ECD patients and to provide clinical analyses of the medical chronicles of these complex patients. Methods: Patients with biopsy proven ECD were audited by a multi-disciplinary team of specialists who formed a coherent timeline of all the substantial clinical events in the evolution of their patients' illness. Results: Seven patients (five men, two women) were recruited to the study. The median age at presentation was 53 years (range: 39 to 62 years). The median follow-up time was 36 months (range: 1 to 72 months). Notable ECD involvement sites included the skeleton (seven), pituitary gland (seven), retroperitoneum (five), central nervous system (four), skin (four), lungs and pleura (four), orbits (three), heart and great vessels (three) and retinae (one). Prominent signs and symptoms were fever (seven), polyuria and polydipsia (six), ataxia and dysarthria (four), bone pain (four), exophthalmos (three), renovascular hypertension (one) and dyspnea (one). The V600E BRAF mutation was verified in three of six patients tested. Interferon-α treatment was beneficial in three of six patients treated. Vemurafenib yielded dramatic neurological improvement in a BRAF mutated patient. Infliximab facilitated pericardial effusion volume reduction. Cladribine improved cerebral blood flow originally compromised by perivenous lesions. Conclusions: ECD is a complex, multi-systemic, clonal entity coalescing both neoplastic and inflammatory elements and strongly dependent on impaired RAS/RAF/MEK/ERK signaling

Modes of wording direct into indirect speech in intercultural communication

This paper aims to determine the modes of wording indirec

Historical retrospective review of idea of university: complementarily of reason and spirituality

Background: In the paper the Idea of the University and its transformations throughout the history are analysed. The content of the Idea of the University was based on understanding of spirituality when the man is upcoming to enlightening. Religion, philosophy, and education get together, when spirituality is defined as the categories and personal characteristics of a human. According to philosophy, spirituality is a non-physical way of a human being, which was granted to him as the ability of self-education. Religion understands spirituality as invariant of enlightening. The scientific-methodical apparatus of education was created to realize the potential ways for raising a person to enlightening in secular or religious schools. The spiritual aura was constantly presented at the University. Methods: A general philosophical approach and comparative historical method were used in the research. Results: Understanding the role of spirituality in the University education was absolutely manifested. The University was based on the idea of going up from individual towards the Universal Truth and Absolute Spirit. Knowledge and Truth are ideological categories of the University. Truth contained the spirituality and rational knowledge in the unity. Conclusions: The University has not lost its Idea throughout the history. The basic conclusion of the paper is that its Idea as well as its essence is the change of its criteria in response to the new historical reality