K63-Linked Ubiquitination in Kinase Activation and Cancer

Ubiquitination has been demonstrated to play a pivotal role in multiple biological functions, which include cell growth, proliferation, apoptosis, DNA damage response, innate immune response, and neuronal degeneration. Although the role of ubiquitination in targeting proteins for proteasome-dependent degradation have been extensively studied and well-characterized, the critical non-proteolytic functions of ubiquitination, such as protein trafficking and kinase activation, involved in cell survival and cancer development, just start to emerge, In this review, we will summarize recent progresses in elucidating the non-proteolytic function of ubiquitination signaling in protein kinase activation and its implications in human cancers. The advancement in the understanding of the novel functions of ubiquitination in signal transduction pathways downstream of growth factor receptors may provide novel paradigms for the treatment of human cancers

A Lipoprotein Lipase–Promoting Agent, NO-1886, Improves Glucose and Lipid Metabolism in High Fat, High Sucrose–Fed New Zealand White Rabbits

The synthetic compound NO-1886 is a lipoprotein lipase activator that lowers plasma triglycerides and elevates high-density lipoprotein cholesterol (HDL-C). Recently, the authors found that NO-1886 also had an action of reducing plasma glucose in high-fat/high-sucrose diet–induced diabetic rabbits. In the current study, we investigated the effects of NO-1886 on insulin resistance and β-cell function in rabbits. Our results showed that high-fat/high-sucrose feeding increased plasma triglyceride, free fatty acid (FFA), and glucose levels and decreased HDL-C level. This diet also induced insulin resistance and impairment of acute insulin response to glucose loading. Supplementing 1% NO-1886 into the high-fat/high-sucrose diet resulted in decreased plasma triglyceride, FFA, and glucose levels and increased HDL-C level. The authors also found a clear increased glucose clearance and a protected acute insulin response to intravenous glucose loading by NO-1886 supplementation. These data suggest that NO-1886 suppresses the elevation of blood glucose in rabbits induced by feeding a high-fat/high-sucrose diet, probably through controlling lipid metabolism and improving insulin resistance

Expansion of Circulating T Follicular Helper Cells in Children with Acute Henoch-Schönlein Purpura

Henoch-Schönlein purpura (HSP) is a common systemic small vessel vasculitis in children with disorder autoimmune responses. T follicular helper (TFH) cells play crucial roles in regulating immune responses. The aim of our study was to investigate the probable role of TFH cells in the pathogenesis of children with HSP. In this study, the frequency of circulating CXCR5+CD4+TFH cells with inducible costimulator (ICOS) expression in the children with acute HSP was significantly higher than that in healthy controls (HCs) but not CXCR5+CD4+TFH cells with programmed death-1 (PD-1) expression. Moreover, serum levels of IL-21 and IL-6 cytokines, IgA, and C3 in HSP children were also significantly higher than those in HCs. A positive correlation was observed between the frequencies of circulating ICOS+CXCR5+CD4+TFH cells and the serum IL-21 or IgA levels of acute HSP children, respectively. Additionally, the mRNA expression levels of interleukin- (IL-) 21, IL-6, and transcriptional factors (B-cell lymphoma-6, Bcl-6) were also significantly increased in peripheral blood from acute HSP children compared to HCs. Taken together, these findings suggest that TFH cells and associated molecules might play critical roles in the pathogenesis of HSP, which are possible therapeutic targets in HSP children

中國光化縣參議會1945年寇災損失冊，由光化縣參議會1946年4月制 (List of items lost in Kwanghwahsien (Guanghua Xian) Council building during the war of 1945, created by Kwanghwahsien (Guanghua Xian) Council in April 1946)

A list of items that were lost in Kwanghwahsien (Guanghua Xian) Council building during the war of 1945. Only furniture and household things for one building were listed. The list was produced in April 1946 by Kwanghwahsien (Guanghua Xian) Council.Galaida Survey Materia

Multifeature Contrast Enhancement Algorithm for Digital Media Images Based on the Diffusion Equation

This paper studies the processing of digital media images using a diffusion equation to increase the contrast of the image by stretching or extending the distribution of luminance data of the image to obtain clearer information of digital media images. In this paper, the image enhancement algorithm of nonlinear diffusion filtering is used to add a velocity term to the diffusion function using a coupled denoising model, which makes the diffusion of the original model smooth, and the interferogram is solved numerically with the help of numerical simulation to verify the denoising processing effect before and after the model correction. To meet the real-time applications in the field of video surveillance, this paper focuses on the optimization of the algorithm program, including software pipeline optimization, operation unit balancing, single instruction multiple data optimization, arithmetic operation optimization, and onchip storage optimization. These optimizations enable the nonlinear diffusion filter-based image enhancement algorithm to achieve high processing efficiency on the C674xDSP, with a processing speed of 25 posts per second for 640×480 size video images. Finally, the significance means a value of super pixel blocks is calculated in superpixel units, and the image is segmented into objects and backgrounds by combining with the Otsu threshold segmentation algorithm to mention the image. In this paper, the proposed algorithm experiments with several sets of Kor Kor resolution remote sensing images, respectively, and the Markov random field model and fully convolutional network (FCN) algorithm are used as the comparison algorithm. By comparing the experimental results qualitatively and quantitatively, it is shown that the algorithm in this paper has an obvious practical effect on contrast enhancement of digital media images and has certain practicality and superiority

Unmanned Vessel Collision Avoidance Algorithm by Dynamic Window Approach Based on COLREGs Considering the Effects of the Wind and Wave

In recent years, the rapid development of artificial intelligence algorithms has promoted the intelligent transformation of the ship industry; unmanned surface vessels (USVs) have become a widely used representative product. The dynamic window approach (DWA) is an effective robotic collision avoidance algorithm; however, there are deficiencies in its application to the ship field. First, the DWA algorithm does not consider International Regulations for Preventing Collisions at Sea (COLREGs), which must be met for ship collision avoidance to ensure the navigational safety of the USV and other ships. Second, the DWA algorithm does not consider the influence of wind and waves on the collision avoidance of USVs in actual navigational environments. Reasonable use of windy and wavy environments not only improves navigational safety but also saves navigational time and fuel consumption, thereby improving the economy. Therefore, this paper proposes an improvement algorithm by DWA referred to as utility DWA (UDWA) based on COLREGs considering the sailing environment. The velocity sampling area was improved by dividing the priority, and the velocity function in the objective function was enhanced to convert the effect of wind and waves on the USVs into a change in velocity. The simulation results showed that the UDWA algorithm optimized the distance to the obstacle ship by 43.25%, 31.36%, and 67.81% in a head-on situation, crossing situation, and overtaking situation, respectively, compared to the COLREGs-compliant DWA algorithm, which considers the COLREGs. The improved algorithm not only follows the COLREGs but also has better flexibility in emergency collision avoidance and can safely and economically navigate and complete collision avoidance in windy and wavy environments

A Novel Method for Estimating the Initial Rotor Position of Brushless Direct Current Motor

AbstractA novel method based on the saturation effect to estimate the rotor initial position of a brushless direct current motor at standstill is presented in this paper. The rotor initial position can be estimated by comparing the magnitude of the stator current vector through setting up voltage space vector. Motor wear reduction and acceleration of the motor up will be realized due to this novel method. Simulation results confirm this method is effective and precise with the maximum estimated error of the initial rotor position can be controlled within 1°

The exploration of the future teaching mode in post-pandemic higher education

Covid-19 has changed the study life of many people with many courses in higher education being moved online. With the situation continuing like this, it is worthwhile to ask the questions such as: is the current provision of online education effective? Will the pandemic change higher education for ever? And what is the future of higher education post-pandemic? To answer these questions, we have conducted a survey to the students at the University of York. The survey provides some clarifications for the current state of online learning. It is discovered that while the adoption of online learning is continuously increasing, the current provision of online teaching during the pandemic has plenty of room to improve. Most participants believe that blended learning e.g. flipped classroom is the future of education post-pandemic; this is in contrast with a small number of participants who believe the in-class teaching is the future of education. In the process of arriving the conclusion, we have also learned a number of best practices for online learning. It is anticipated that the evidence collected from this study will shed light for university senior management to make strategic decisions in preparation for the future of education post-pandemic

Enhanced Electrical Performance and Stability of Solution-Processed Thin-Film Transistors with In₂O₃/In₂O₃:Gd Heterojunction Channel Layer

The use of the semiconductor heterojunction channel layer has been explored as a method for improving the performance of metal oxide thin-film transistors (TFTs). The excellent electrical performance and stability of heterojunction TFTs is easy for vacuum-based techniques, but difficult for the solution process. Here, we fabricated In2O3/In2O3:Gd (In2O3/InGdO) heterojunction TFTs using a solution process and compared the electrical properties with single-layer In2O3 TFTs and In2O3:Gd (InGdO) TFTs. The In2O3/InGdO TFT consisted of a highly conductive In2O3 film as the primary transmission layer and a subconductive InGdO film as the buffer layer, and exhibited excellent electrical performance. Furthermore, by altering the Gd dopant concentration, we obtained an optimal In2O3/InGdO TFT with a higher saturation mobility (µ) of 4.34 cm2V−1s−1, a near-zero threshold voltage (Vth), a small off-state current (Ioff) of 1.24×10−9 A, a large on/off current ratio (Ion/Ioff) of 3.18×105, a small subthreshold swing (SS), and an appropriate positive bias stability (PBS). Finally, an aging test was performed after three months, indicating that In2O3/InGdO TFTs enable long-term air stability while retaining a high-mobility optimal switching property. This study suggests that the role of a high-performance In2O3/InGdO heterojunction channel layer fabricated by the solution process in the TFT is underlined, which further explores a broad pathway for the development of high-performance, low-cost, and large-area oxide electronics