Protein folding tames chaos

Protein folding produces characteristic and functional three-dimensional structures from unfolded polypeptides or disordered coils. The emergence of extraordinary complexity in the protein folding process poses astonishing challenges to theoretical modeling and computer simulations. The present work introduces molecular nonlinear dynamics (MND), or molecular chaotic dynamics, as a theoretical framework for describing and analyzing protein folding. We unveil the existence of intrinsically low dimensional manifolds (ILDMs) in the chaotic dynamics of folded proteins. Additionally, we reveal that the transition from disordered to ordered conformations in protein folding increases the transverse stability of the ILDM. Stated differently, protein folding reduces the chaoticity of the nonlinear dynamical system, and a folded protein has the best ability to tame chaos. Additionally, we bring to light the connection between the ILDM stability and the thermodynamic stability, which enables us to quantify the disorderliness and relative energies of folded, misfolded and unfolded protein states. Finally, we exploit chaos for protein flexibility analysis and develop a robust chaotic algorithm for the prediction of Debye-Waller factors, or temperature factors, of protein structures

Investigation into Mobile Learning Framework in Cloud Computing Platform

Abstract—Cloud computing infrastructure is increasingly used for distributed applications. Mobile learning applications deployed in the cloud are a new research direction. The applications require specific development approaches for effective and reliable communication. This paper proposes an interdisciplinary approach for design and development of mobile applications in the cloud. The approach includes front service toolkit and backend service toolkit. The front service toolkit packages data and sends it to a backend deployed in a cloud computing platform. The backend service toolkit manages rules and workflow, and then transmits required results to the front service toolkit. To further show feasibility of the approach, the paper introduces a case study and shows its performance