Historical Accuracy in Theatre

Do you love historical dramas for the history, or for the drama? Those performances are far more fictional than fact, but research has shown that historical changes can seriously shape the knowledge of audience members. Why do writers change history in performance? Is it possible to write a play that is entirely true to history? In this presentation, I explore the limitations of historical accuracy in theatre in the creation of an original script, Just Anne. By detailing the writing and workshop process, I examine questions about ethical theatremaking, archival work, dramatic technique, and more

'Have Ye Not Heard That We Cannot Serve Two Masters?': The Platonism of Mary Wollstonecraft

Together with David Hume, Jean-Jacques Rousseau and Adam Smith, Mary Wollstonecraft thought modern commercial society exacerbated the psychological need of most of their members to seek the approbation of others. Like them, she thought the better part of her contemporaries were caught in a hall of mirrors and sought to be esteemed for their appearance. In her view the contrivances this entailed distorted individual characters, relationships, and society as a whole. Though she partook of a European wide philosophical debate, she came to it from the very unique perspective of a largely self-taught English woman and in a large part from what might be meaningfully conceived as a Platonist perspective. In examining how this might be so, this chapter does not seek to make Wollstonecraft a Platonist as opposed to, say, an Aristotelian, much less a Christian. Her moral and political critique made her eclectic in her use of ideas and argument. She seems however to have been inspired by conceptions of the soul, love, truth and virtue that have their origins in Platonism. Considering her in this light provides greater insights into her philosophy of mind as well as her social and political views and provides a greater understanding of the continued importance of Platonism in the latter part of the eighteenth century

High-throughput sequencing defines donor and recipient HLA B-cell epitope frequencies for prospective matching in transplantation

Compatibility for human leukocyte antigen (HLA) genes between transplant donors and recipients improves graft survival but prospective matching is rarely performed due to the vast heterogeneity of this gene complex. To reduce complexity, we have combined next-generation sequencing and in silico mapping to determine transplant population frequencies and matching probabilities of 150 antibody-binding eplets across all 11 classical HLA genes in 2000 ethnically heterogeneous renal patients and donors. We show that eplets are more common and uniformly distributed between donors and recipients than the respective HLA isoforms. Simulations of targeted eplet matching shows that a high degree of overall compatibility, and perfect identity at the clinically important HLA class II loci, can be obtained within a patient waiting list of approximately 250 subjects. Internal epitope-based allocation is thus feasible for most major renal transplant programs, while regional or national sharing may be required for other solid organs. Tran et al. combine high throughput sequencing, structural biology and computational simulation to determine the HLA allele and antibody-defined epitope frequencies in renal transplant patients and donors. These results demonstrate the feasibility of HLA epitope matching using data from a national transplantation program.Personalised Therapeutic