Examining the Feasibility of Partnering with Cooperative Extension to Advance Statewide Physical Education Policies in Oregon

Optimizing physical education (PE) is a proven approach to increase children’s physical activity. Oregon law requires elementary schools to provide PE for \u3e 150 minutes/week. One strategy to meet the required minutes is for classroom teachers to deliver PE, which is permissible using curricula aligned to national PE standards. Be Physically Active 2Day (BEPA 2.0) is a unique classroom-based physical activity brain break curriculum aligned to PE standards. We evaluated the effectiveness of training school faculty to use BEPA 2.0 via a unique partnership with Cooperative Extension. Extension trainers (ET) were trained by a BEPA 2.0 Master Trainer (MT). School faculty were subsequently trained by ET (n = 94) and MT (n = 58). Participants completed post-training surveys to assess confidence, comprehension, and self-efficacy to implement BEPA 2.0. Survey scores were compared between MT and ET groups using the Wilcoxon-Mann-Whitney test. There were no differences between MT and ET training groups in perceived confidence, comprehension, or self-efficacy to implement BEPA 2.0 after training. ET were as effective as MT, indicating the train-the-trainer approach is a promising strategy to enhance BEPA 2.0 dissemination. Cooperative Extension partnerships may be an overlooked mechanism to enhance physical activity promotion efforts

Generating rural options for Weight: Healthy Kids and Communities: examining the rural family home nutrition and physical activity environment

Childhood health is a strong determinant of adult health, including overweight and obesity. Rural children and adults experience a greater obesity prevalence compared to children and adults living in more urban places. The goal of Generating Rural Options for Weight-Healthy Kids & Communities (GROW HKC) is to prevent childhood obesity and promote healthy weight among children and families living in rural places. GROW HKC focuses efforts in rural communities, schools, and families. The data presented here focus on the rural family home environment. PURPOSE: The purpose of this investigation was to examine the family home food and physical activity environment among rural families

Engaging Residents in Participatory Photomapping and Readiness Conversations to Address the Rural Obesogenic Context

Extension engaged rural Idaho community stakeholders to assess local resources and readiness to address obesogenic contexts through use of the Extension tool HEAL MAPPS. Through participatory photomapping, focus group involvement, and a community readiness conversation, residents identified environmental resources and local efforts as supports for and barriers to healthful eating and active living. Findings indicated that the community was vaguely aware that rural obesity risk is a socioenvironmentally determined issue. Extension professionals using HEAL MAPPS effectively promoted new and shared knowledge of weight health resources among community members, enabled rural residents to have a voice in addressing the community context, and empowered community actions

A meta-analysis of individual participant data reveals an association between circulating levels of IGF-I and prostate cancer risk

The role of insulin-like growth factors (IGF) in prostate cancer development is not fully understood. To investigate the association between circulating concentrations of IGFs (IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3) and prostate cancer risk, we pooled individual participant data from 17 prospective and two cross-sectional studies, including up to 10,554 prostate cancer cases and 13,618 control participants. Conditional logistic regression was used to estimate the ORs for prostate cancer based on the study-specific fifth of each analyte. Overall, IGF-I, IGF-II, IGFBP-2, and IGFBP-3 concentrations were positively associated with prostate cancer risk (Ptrend all ≤ 0.005), and IGFBP-1 was inversely associated weakly with risk (Ptrend = 0.05). However, heterogeneity between the prospective and cross-sectional studies was evident (Pheterogeneity = 0.03), unless the analyses were restricted to prospective studies (with the exception of IGF-II, Pheterogeneity = 0.02). For prospective studies, the OR for men in the highest versus the lowest fifth of each analyte was 1.29 (95% confidence interval, 1.16-1.43) for IGF-I, 0.81 (0.68-0.96) for IGFBP-1, and 1.25 (1.12-1.40) for IGFBP-3. These associations did not differ significantly by time-to-diagnosis or tumor stage or grade. Aftermutual adjustment for each of the other analytes, only IGF-I remained associated with risk. Our collaborative study represents the largest pooled analysis of the relationship between prostate cancer risk and circulating concentrations of IGF-I, providing strong evidence that IGF-I is highly likely to be involved in prostate cancer development.</p

Neural circuitry underlying sustained attention in healthy adolescents and in ADHD symptomatology

Moment-to-moment reaction time variability on tasks of attention, often quantified by intra-individual response variability (IRV), provides a good indication of the degree to which an individual is vulnerable to lapses in sustained attention. Increased IRV is a hallmark of several disorders of attention, including Attention-Deficit/Hyperactivity Disorder (ADHD). Here, task-based fMRI was used to provide the first examination of how average brain activation and functional connectivity patterns in adolescents are related to individual differences in sustained attention as measured by IRV. We computed IRV in a large sample of adolescents (n=758) across 'Go' trials of a Stop Signal Task (SST). A data-driven, multi-step analysis approach was used to identify networks associated with low IRV (i.e., good sustained attention) and high IRV (i.e., poorer sustained attention). Low IRV was associated with greater functional segregation (i.e., stronger negative connectivity) amongst an array of brain networks, particularly between cerebellum and motor, cerebellum and prefrontal, and occipital and motor networks. In contrast, high IRV was associated with stronger positive connectivity within the motor network bilaterally and between motor and parietal, prefrontal, and limbic networks. Consistent with these observations, a separate sample of adolescents exhibiting elevated ADHD symptoms had increased fMRI activation and stronger positive connectivity within the same motor network denoting poorer sustained attention, compared to a matched asymptomatic control sample. With respect to the functional connectivity signature of low IRV, there were no statistically significant differences in networks denoting good sustained attention between the ADHD symptom group and asymptomatic control group. We propose that sustained attentional processes are facilitated by an array of neural networks working together, and provide an empirical account of how the functional role of the cerebellum extends to cognition in adolescents. This work highlights the involvement of motor cortex in the integrity of sustained attention, and suggests that atypically strong connectivity within motor networks characterizes poor attentional capacity in both typically developing and ADHD symptomatic adolescents

A Collaborative Analysis of Individual Participant Data from 19 Prospective Studies Assesses Circulating Vitamin D and Prostate Cancer Risk.

Previous prospective studies assessing the relationship between circulating concentrations of vitamin D and prostate cancer risk have shown inconclusive results, particularly for risk of aggressive disease. In this study, we examine the association between prediagnostic concentrations of 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)2D] and the risk of prostate cancer overall and by tumor characteristics. Principal investigators of 19 prospective studies provided individual participant data on circulating 25(OH)D and 1,25(OH)2D for up to 13,462 men with incident prostate cancer and 20,261 control participants. ORs for prostate cancer by study-specific fifths of season-standardized vitamin D concentration were estimated using multivariable-adjusted conditional logistic regression. 25(OH)D concentration was positively associated with risk for total prostate cancer (multivariable-adjusted OR comparing highest vs. lowest study-specific fifth was 1.22; 95% confidence interval, 1.13-1.31; P trend < 0.001). However, this association varied by disease aggressiveness (P heterogeneity = 0.014); higher circulating 25(OH)D was associated with a higher risk of nonaggressive disease (OR per 80 percentile increase = 1.24, 1.13-1.36) but not with aggressive disease (defined as stage 4, metastases, or prostate cancer death, 0.95, 0.78-1.15). 1,25(OH)2D concentration was not associated with risk for prostate cancer overall or by tumor characteristics. The absence of an association of vitamin D with aggressive disease does not support the hypothesis that vitamin D deficiency increases prostate cancer risk. Rather, the association of high circulating 25(OH)D concentration with a higher risk of nonaggressive prostate cancer may be influenced by detection bias. SIGNIFICANCE: This international collaboration comprises the largest prospective study on blood vitamin D and prostate cancer risk and shows no association with aggressive disease but some evidence of a higher risk of nonaggressive disease