Signal processing aspects of the low frequency array

In the Northern part of the Netherlands ASTRON is building the largest radio telescope in the world for low frequencies. The telescope is based on phased array principles and is known as the LOw Frequency ARray (LOFAR). LOFAR is optimized for detecting astronomical signals in the 30-80 MHz and 120-240 MHz frequency window. LOFAR detects the incoming radio signals by using an array of simple omni-directional antennas. The antennas are grouped in so called stations mainly to reduce the amount of data generated. More than fifty stations will be built, mainly within a circle of 150 kilometres in diameter but also internationally. The signals of all the stations are distributed to the central processor facility, where all the station signals are correlated with each other. In this paper the signal processing aspects on system level will be presented mainly for the astronomical application.\ud \u

Implementation of LOFAR RFI mitigation strategy

ASTRON is building the world’s largest radio telescope for low frequencies, LOFAR. LOFAR is optimized for detecting astronomical signals in the 30-80 MHz and 120-240 MHz frequency windows. Since this part of the spectrum is in extensive use by others, a special RFI mitigation strategy is implemented which will be described in the paper. International RFI measurements will be presented and we will focus on practical implementation issues such as the impact of Digital Video Broadcast, RF emissions from power lines and the influence of large wind turbines on the EM environmen

Critical illness induces alternative activation of M2 macrophages in adipose tissue

INTRODUCTION: We recently reported macrophage accumulation in adipose tissue of critically ill patients. Classically activated macrophage accumulation in adipose tissue is a known feature of obesity, where it is linked with increasing insulin resistance. However, the characteristics of adipose tissue macrophage accumulation in critical illness remain unknown. METHODS: We studied macrophage markers with immunostaining and gene expression in visceral and subcutaneous adipose tissue from healthy control subjects (n=20) and non-surviving prolonged critically ill patients (n=61). For comparison, also subcutaneous in vivo adipose tissue biopsies were studied from 15 prolonged critically ill patients. RESULTS: Subcutaneous and visceral adipose tissue biopsies from nonsurviving prolonged critically ill patients displayed a large increase in macrophage staining. This staining corresponded with elevated gene expression of "alternatively activated" M2 macrophage markers arginase-1, IL-10 and CD163 and low levels of the "classically activated" M1 macrophage markers tumor necrosis factor (TNF)-alpha and inducible nitric-oxide synthase (iNOS). Immunostaining for CD163 confirmed positive M2 macrophage staining in both visceral and subcutaneous adipose tissue biopsies from critically ill patients. Surprisingly, circulating levels and tissue gene expression of the alternative M2 activators IL-4 and IL-13 were low and not different from controls. In contrast, adipose tissue protein levels of peroxisome proliferator-activated receptor-gamma PPARgamma a nuclear receptor required for M2 differentiation and acting downstream of IL-4, was markedly elevated in illness. In subcutaneous abdominal adipose tissue biopsies from surviving critically ill patients, we could confirm positive macrophage staining with CD68 and CD163. We also could confirm elevated arginase-1 gene expression and elevated PPARgamma protein levels. CONCLUSIONS: Unlike obesity, critical illness evokes adipose tissue accumulation of alternatively activated M2 macrophages, which have local anti-inflammatory and insulin sensitizing features. This M2 macrophage accumulation may contribute to the previously observed protective metabolic activity of adipose tissue during critical illness.status: publishe

A very brief description of LOFAR - the Low Frequency Array

LOFAR (Low Frequency Array) is an innovative radio telescope optimized for the frequency range 30-240 MHz. The telescope is realized as a phased aperture array without any moving parts. Digital beam forming allows the telescope to point to any part of the sky within a second. Transient buffering makes retrospective imaging of explosive short-term events possible. The scientific focus of LOFAR will initially be on four key science projects (KSPs): 1) detection of the formation of the very first stars and galaxies in the universe during the so-called epoch of reionization by measuring the power spectrum of the neutral hydrogen 21-cm line (Shaver et al. 1999) on the ~5' scale; 2) low-frequency surveys of the sky with of order $10^8$ expected new sources; 3) all-sky monitoring and detection of transient radio sources such as gamma-ray bursts, x-ray binaries, and exo-planets (Farrell et al. 2004); and 4) radio detection of ultra-high energy cosmic rays and neutrinos (Falcke & Gorham 2003) allowing for the first time access to particles beyond 10^21 eV (Scholten et al. 2006). Apart from the KSPs open access for smaller projects is also planned. Here we give a brief description of the telescope.Comment: 2 pages, IAU GA 2006, Highlights of Astronomy, Volume 14, K.A. van der Hucht, e

Modeling correlation of quantized noise and periodic signals

A model for determining the cross-correlation function of partially correlated noise is presented. In this model a strong interferer is included and represented by a periodic signal common to both channels of the correlator. A general expression for the correlation function is deduced and verified. The power spectrum of a calculated correlation function is compared with a simulation. The results presented in this paper form a base for the design of modern multibit correlators. These are part of future generation radio astronomy receivers which increasingly have to cope with man-made interfering signals

LOFAR - low frequency array

Nog een paar maanden en dan wordt de grootste radiotelescoop ter wereld officieel geopend: LOFAR, de ‘Low Frequency Arraÿ'.LOFAR is een nieuwe radiotelescoop die in Nederland gebouwd wordt door ASTRON, de Stichting Astronomisch Onderzoek in Nederland. Met LOFAR heeft Nederland er straks een uniek instrument bij. Voor het eerst wordt het frequentiegebied van 30 tot 240 MHz onderzocht. In dit artikel zullen we LOFAR beschrijven: van de astronomische mogelijkheden met de nieuwe telescoop tot aan een nadere technische beschrijving van het instrument.\u

Mitochondrial fusion, fission, and biogenesis in prolonged critically ill patients

Context:Critical illness induces swelling, enlargement, and dysfunction of mitochondria, which in liver, but not in muscle, is aggravated by excessive hyperglycemia. We previously demonstrated impaired autophagic clearance of damaged mitochondria in fed prolonged critically ill patients. Impaired fusion/fission-mediated repair and/or renewal through biogenesis may further accentuate mitochondrial abnormalities.Objective:We studied mitochondrial fusion/fission and biogenesis and how these are affected by preventing hyperglycemia with insulin during critical illness.Design and Setting:Patients admitted to a university hospital surgical/medical intensive-care unit participated in a randomized study.Patients:We studied adult prolonged critically ill patients vs. controls.Intervention:Tolerating hyperglycemia up to 215 mg/dl was compared with intensive insulin therapy targeting normoglycemia (80-110 mg/dl).Main Outcome Measures:In liver and skeletal muscle, we quantified levels of several proteins involved in mitochondrial fusion/fission and biogenesis.Results:Key players in mitochondrial fusion/fission and biogenesis were up-regulated in postmortem liver (1.4- to 3.7-fold) and rectus abdominis (1.2- to 4.2-fold) but not in in vivo or postmortem vastus lateralis biopsies of critically ill patients. Maintaining normoglycemia with insulin attenuated the hepatic response in the mitochondrial fusion/fission process but did not affect the markers of mitochondrial biogenesis in liver or muscle.Conclusions:Our observations suggest tissue-dependent attempts of compensatory activation of mitochondrial repair mechanisms during critical illness. Considering the previously observed persistent mitochondrial damage, this activation may be insufficient and contribute to mitochondrial dysfunction. Suppressed activation of fusion/fission when excessive hyperglycemia is prevented with insulin may reflect reduced need for diluting (less) damage during normoglycemia or, alternatively, a suppressive effect of insulin on repair.status: publishe

Sur la possibilité d'une fluorescence cométaire excitée par la raie d'émission Lyman alpha-solaire

One may Wonder whether the solar emission line at Lyman α may not excite a fluorescence in cometary molecules. The authors show that no evidence for such a fluorescence is found at the present time