A NEW PREDICTION SYSTEM FOR EVALUATION OF OPTIMAL FINAL HEIGHT IN CHILDREN WITH GROWTH HORMONE DEFICIENCY: IGRO

WOS: 000412595405178

Rapid Acting Insulin Analogue Treatment in Children and Adolescents with Type 1 Diabetes Mellitus; Insulin Glulisine Experience

WOS: 000384166800599

THE ADHERENCE TO GROWTH HORMONE THERAPY IN CHILDREN WITH GROWTH HORMONE DEFICIENCY

WOS: 000412595403207

Evaluation of Body Composition via Bioelectrical Impedance Analysis in Children with Subclinical Hypothyroidism and Effect of LT4 Treatment; Follow-up Results

KILINC, FATMA/0000-0001-8297-958XWOS: 000384166801535

The effect of subclinical hypothyroidism on body composition parameters in children

WOS:000538622200001PubMed: 32460403Background It's known that overt hypothyroidism increases body fat content and weight. There's limited research about the effect of subclinical hypothyroidism (SH) on body composition in children and the effect of LT4 treatment. We aimed to evaluate body composition parameters in healthy subjects and in children with mild SH (MSH) and determine the effect of LT4 treatment. Methods Sixty-four healthy children and 32 children with MSH were included. Anthropometric measurements and hormonal parameters were evaluated. Body composition was evaluated using bioelectric impedance analysis (BIA). Patients were put on LT4 treatment. BIA was performed again after 12 months of therapy. Results There was no significant difference between the anthropometric parameters and basal metabolic rate of the healthy children and the MSH group. The percentage of trunk muscle mass (TMM) in the MSH group was lower than in the control group (P .05). Conclusions The percentage of TMM in children with MSH was found lower than healthy control group. After LT4 treatment, the percentage of the FFM, TMM and TFFM were increased and the difference between percentage of TMM in children with MSH and healthy controls was insignificant. Our data indicated that MSH might be associated with early changes in body composition parameters

THE EVALUATION OF PATIENTS RECEIVING GROWTH HORMONE THERAPY

WOS: 000412595402073

Evaluation of Growth Pattern in Prader-Willi Syndrome

WOS: 000384166801528

Intracranial Lesions in Children and Adolescents with Morbid Obesity

WOS: 000400660600003PubMed: 28418336Background: Intracranial lesions may affect the hypothalamo-hypophyseal axis and lead to some neuroendocrinological dysfunctions (hyperphagia, sleep disorders and hormonal dysfunctions). There is a very limited number of studies about childhood obesity and intracranial lesions. Aims: To evaluate the incidence of intracranial lesions and its role in clinical symptoms and aetiology in cases with morbid obesity who have been admitted to the paediatric endocrinology department with this complaint. Study Design: Cross-sectional study. Methods: A total of 120 cases admitted to the paediatric endocrinology department with the complaint of morbid obesity between 2002 and 2015 were included in this study. A detailed history was taken and a physical examination was performed; biochemical, hormonal parameters were evaluated. Contrast dynamic magnetic resonance imaging was performed in order to visualize cranial pathologies. Results: An intracranial lesions was detected in 16.6% of the patients and 55% of these lesions were adenoma of the hypophysis. Prolactin levels were increased in six patients but front hypophyseal hormone levels were within normal range in the rest of the patients. Growth velocity of the patients was not affected. Conclusion: In our study, the incidence of intracranial lesions in children and adolescents with morbid obesity was much higher than in the normal population. According to this data, we are of the opinion that contrast dynamic magnetic resonance imaging is helpful in children with morbid obesity for the early detection of the mass before it causes any clinical or neurological symptoms and in the prevention of future complications