Precision lattice QCD calculations and predictions of fundamental physics in heavy quark systems

I describe the recent success in performing accurate calculations of the effects of the strong force on particles containing bottom and charm quarks. Since quarks are never seen in isolation, and so cannot be studied directly, numerical simulations are key to understanding the properties of these particles and extracting information about the quarks. The results have direct impact on the worldwide experimental programme that is aiming to determine the parameters of the Standard Model of particle physics precisely and thereby uncover or constrain the possibilities for physics beyond the Standard Model. The numerical simulation of the strong force is a huge computational task and the recent success is the result of international collaboration in developing techniques that are fast enough to do the calculations on powerful supercomputers.Comment: Invited talk at SCIDAC 2006, Denver, June 2006. 15 page

One-Loop Matching of the Heavy-Light A_0 and V_0 Currents with NRQCD Heavy and Improved Naive Light Quarks

One-loop matching of heavy-light currents is carried out for a highly improved lattice action, including the effects of dimension 4 O(1/M) and O(a) operators. We use the NRQCD action for heavy quarks, the Asqtad improved naive action for light quarks, and the Symanzik improved glue action. As part of the matching procedure we also present results for the NRQCD self energy and for massless Asqtad quark wavefunction renormalization with improved glue.Comment: 25 pages, 3 eps-figure

Yeni bir insansız hava aracının (SUAVİ) prototip üretimi ve algılayıcı-eyleyici entegrasyonu

Bu çalısmada, dört-döner rotoru ile helikopter gibi dikine kalkıs ve inis yapabilen aynı zamanda da uçak gibi uzun menzil yatay uçus yeteneğine sahip yeni bir insansız otonom hava aracının mekanik ve aerodinamik tasarımı, karbon kompozit imalatı, algılayıcı eyleyici sistem entegrasyonu ve uçus deneyleri anlatılmıstır. Gelistirilen sistem ve içinde kullanılan algılayıcı eyleyici entegrasyonunun basarımı benzetim ve deneylerle doğrulanmıstır

Consensus Middle East and North Africa Registry on Inborn Errors of Immunity

Background: Inborn errors of immunity (IEIs) are a heterogeneous group of genetic defects of immunity, which cause high rates of morbidity and mortality mainly among children due to infectious and non-infectious complications. The IEI burden has been critically underestimated in countries from middle- and low-income regions and the majority of patients with IEI in these regions lack a molecular diagnosis. Methods: We analyzed the clinical, immunologic, and genetic data of IEI patients from 22 countries in the Middle East and North Africa (MENA) region. The data was collected from national registries and diverse databases such as the Asian Pacific Society for Immunodeficiencies (APSID) registry, African Society for Immunodeficiencies (ASID) registry, Jeffrey Modell Foundation (JMF) registry, J Project centers, and International Consortium on Immune Deficiency (ICID) centers. Results: We identified 17,120 patients with IEI, among which females represented 39.4%. Parental consanguinity was present in 60.5% of cases and 27.3% of the patients were from families with a confirmed previous family history of IEI. The median age of patients at the onset of disease was 36 months and the median delay in diagnosis was 41 months. The rate of registered IEI patients ranges between 0.02 and 7.58 per 100,000 population, and the lowest rates were in countries with the highest rates of disability-adjusted life years (DALY) and death rates for children. Predominantly antibody deficiencies were the most frequent IEI entities diagnosed in 41.2% of the cohort. Among 5871 patients genetically evaluated, the diagnostic yield was 83% with the majority (65.2%) having autosomal recessive defects. The mortality rate was the highest in patients with non-syndromic combined immunodeficiency (51.7%, median age: 3.5 years) and particularly in patients with mutations in specific genes associated with this phenotype (RFXANK, RAG1, and IL2RG). Conclusions: This comprehensive registry highlights the importance of a detailed investigation of IEI patients in the MENA region. The high yield of genetic diagnosis of IEI in this region has important implications for prevention, prognosis, treatment, and resource allocation

Mutations affecting the actin regulator WD repeat–containing protein 1 lead to aberrant lymphoid immunity

Background: The actin-interacting protein WD repeat–containing protein 1 (WDR1) promotes cofilin-dependent actin filament turnover. Biallelic WDR1 mutations have been identified recently in an immunodeficiency/autoinflammatory syndrome with aberrant morphology and function of myeloid cells. Objective: Given the pleiotropic expression of WDR1, here we investigated to what extent it might control the lymphoid arm of the immune system in human subjects. Methods: Histologic and detailed immunologic analyses were performed to elucidate the role of WDR1 in the development and function of B and T lymphocytes. Results: Here we identified novel homozygous and compound heterozygous WDR1 missense mutations in 6 patients belonging to 3 kindreds who presented with respiratory tract infections, skin ulceration, and stomatitis. In addition to defective adhesion and motility of neutrophils and monocytes, WDR1 deficiency was associated with aberrant T-cell activation and B-cell development. T lymphocytes appeared to develop normally in the patients, except for the follicular helper T-cell subset. However, peripheral T cells from the patients accumulated atypical actin structures at the immunologic synapse and displayed reduced calcium flux and mildly impaired proliferation on T-cell receptor stimulation. WDR1 deficiency was associated with even more severe abnormalities of the B-cell compartment, including peripheral B-cell lymphopenia, paucity of B-cell progenitors in the bone marrow, lack of switched memory B cells, reduced clonal diversity, abnormal B-cell spreading, and increased apoptosis on B-cell receptor/Toll-like receptor stimulation. Conclusion: Our study identifies a novel role for WDR1 in adaptive immunity, highlighting WDR1 as a central regulator of actin turnover during formation of the B-cell and T-cell immunologic synapses

Suboptimal Solutions for Time Varying Time Delayed MPC Controllers

Model Predictive Control (MPC) with constraints is still an interesting subject and offers many problems to work on. This study basically aims to understand the optimization process and the decrease of convex quadratic costs in a single model predictive controller. For those processes where the system dynamics change so slowly it is essential to obtain the control law as soon as possible to minimize the time delay on the controller side. This study proposes an early termination of the optimization process and the suboptimal solution to the quadratic programming. To define the early termination in the following chapters it is discussed and explained when, where. The implementation of the strategy is also illustrated with a case study and it is compared to the LQR controller for the regulator problem

Real object recognition using moment invariants

Moments and functions of moments have been extensively employed as invariant global features of images in pattern recognition. In this study, a flexible recoanition system that can compute the good features for high classification of 3-D real objects is investigated. For object recognition, regardless of orientation, size and position, feature vectors are computed with the help of nonlinear moment invariant functions. Representations of objects using two-dimensional images that are taken from different angles of view are the main features leading us to our objective. After efficient feature extraction, the main focus of this study, the recognition performance of classifiers in conjunction with moment-based feature sets, is introduced

Reducing Moment and Current Fluctuations of Induction Motor System of Electrical Vehicles by using Adaptive Field Oriented Control

This paper presents an adaptive field oriented control (FOC) method for induction motor systems (IMSs). After the details of the method are presented, the conventional FOC is applied to control the moment of the system in order to observe current and moment fluctuations. And then, the adaptive FOC method is applied to the EMS to change the switching condition of the voltage vectors. In terms of current, moment and electromagnetic flux, the conventional FOC and the adaptive FOC methods are compared. The proposed method gives better results at the IMS output. Simulation results show that current and moment fluctuations can be reduced by using the proposed approach