Scheduling aircraft landings - the static case

This is the publisher version of the article, obtained from the link below.In this paper, we consider the problem of scheduling aircraft (plane) landings at an airport. This problem is one of deciding a landing time for each plane such that each plane lands within a predetermined time window and that separation criteria between the landing of a plane and the landing of all successive planes are respected. We present a mixed-integer zero–one formulation of the problem for the single runway case and extend it to the multiple runway case. We strengthen the linear programming relaxations of these formulations by introducing additional constraints. Throughout, we discuss how our formulations can be used to model a number of issues (choice of objective function, precedence restrictions, restricting the number of landings in a given time period, runway workload balancing) commonly encountered in practice. The problem is solved optimally using linear programming-based tree search. We also present an effective heuristic algorithm for the problem. Computational results for both the heuristic and the optimal algorithm are presented for a number of test problems involving up to 50 planes and four runways.J.E.Beasley. would like to acknowledge the financial support of the Commonwealth Scientific and Industrial Research Organization, Australia

Gravity in the Local Universe : density and velocity fields using CosmicFlows-4

This article publicly releases three-dimensional reconstructions of the local Universe gravitational field below z=0.8 that were computed using the CosmicFlows-4 catalog of 56,000 galaxy distances and its sub-sample of 1,008 type Ia supernovae distances. The article also provides measurements of the growth rate of structure using the pairwise correlation of radial peculiar velocities f sigma8 = 0.38(+/-0.04) (ungrouped CF4), f sigma8 = 0.36(+/-0.05) (grouped CF4), f sigma8 = 0.30(+/-0.06) (SNIa) and of the bulk flow in the 3D reconstructed Local Universe of 230 +/- 136 km s-1 at 300 Mpc of distance from the observer. The exploration of 10,000 reconstructions gives that the distances delivered by the Cosmicflows-4 catalog are compatible with a Hubble constant of H0 = 74.5 +/- 0.1 (grouped CF4), H0 = 75.0 +/- 0.35 (ungrouped CF4) and H0 = 75.5 +/- 0.95 (CF4 SNIa subsample).Comment: Submitted A&A Oct 31st, 2022 / (AA/2022/45331) / Accepted January 2023 All Figures and values updated after the december 2022 major correction in CF4 catalo

Isospin diffusion in semi-peripheral 58Ni^{58}Ni + 197Au^{197}Au collisions at intermediate energies (I): Experimental results

Isospin diffusion in semi-peripheral collisions is probed as a function of the dissipated energy by studying two systems $^{58}Ni$ + $^{58}Ni$ and $^{58}Ni$ + $^{197}Au$, over the incident energy range 52-74\AM. A close examination of the multiplicities of light products in the forward part of phase space clearly shows an influence of the isospin of the target on the neutron richness of these products. A progressive isospin diffusion is observed when collisions become more central, in connection with the interaction time

Nuclear multifragmentation time-scale and fluctuations of largest fragment size

Distributions of the largest fragment charge, Zmax, in multifragmentation reactions around the Fermi energy can be decomposed into a sum of a Gaussian and a Gumbel distribution, whereas at much higher or lower energies one or the other distribution is asymptotically dominant. We demonstrate the same generic behavior for the largest cluster size in critical aggregation models for small systems, in or out of equilibrium, around the critical point. By analogy with the time-dependent irreversible aggregation model, we infer that Zmax distributions are characteristic of the multifragmentation time-scale, which is largely determined by the onset of radial expansion in this energy range.Comment: Accepted for publication in Physical Review Letters on 8/4/201

Constrained caloric curves and phase transition for hot nuclei

Simulations based on experimental data obtained from multifragmenting quasi-fused nuclei produced in central $^{129}$Xe + $^{nat}$Sn collisions have been used to deduce event by event freeze-out properties in the thermal excitation energy range 4-12 AMeV [Nucl. Phys. A809 (2008) 111]. From these properties and the temperatures deduced from proton transverse momentum fluctuations, constrained caloric curves have been built. At constant average volumes caloric curves exhibit a monotonic behaviour whereas for constrained pressures a backbending is observed. Such results support the existence of a first order phase transition for hot nuclei.Comment: 14 pages, 5 figures, accepted in Physics Letters

Isospin Diffusion in 58^{58}Ni-Induced Reactions at Intermediate Energies

Isospin diffusion is probed as a function of the dissipated energy by studying two systems $^{58}$Ni+$^{58}$Ni and $^{58}$Ni+$^{197}$Au, over the incident energy range 52-74\AM. Experimental data are compared with the results of a microscopic transport model with two different parameterizations of the symmetry energy term. A better overall agreement between data and simulations is obtained when using a symmetry term with a potential part linearly increasing with nuclear density. The isospin equilibration time at 52 \AM{} is estimated to 130$\pm$10 fm/$c$

The prominent role of the heaviest fragment in multifragmentation and phase transition for hot nuclei

The role played by the heaviest fragment in partitions of multifragmenting hot nuclei is emphasized. Its size/charge distribution (mean value, fluctuations and shape) gives information on properties of fragmenting nuclei and on the associated phase transition.Comment: 11 pages, Proceedings of IWND09, August 23-25, Shanghai (China

Regulation of the mTOR signaling pathway: from laboratory bench to bedside and back again

Recent publications have moved us significantly closer to a complete understanding of the mammalian target of rapamycin (mTOR) signaling pathway, which plays a central role in the control of growth and metabolism and is dysregulated in a broad spectrum of human diseases, including cancer, tuberous sclerosis, diabetes, and cardiovascular and neurodegenerative diseases. Rapamycin-related mTOR inhibitors have shown clinical efficacy in several of these diseases, and novel inhibitors currently in development will be valuable tools for further dissections of the mTOR signaling network in human health and disease