Artrosis, estado funcional y fragilidad de una población de personas mayores en Portugal: estudio de los factores asociados y de la actividad física

Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Medicina Preventiva y Salud Pública y Microbiología. Fecha de lectura: 26 de Marzo de 201

Clube de revistas: experiência de um grupo de pesquisa

Introduction: the Journal Club (IC) is a teaching and learning strategy developed by individuals who meet to discuss scientific articles in periodicals. Objective: to describe the experience of the JC strategy at the Group for Studies and Research in Health Services Administration and Nursing Management (Gepag). Method: case studies or scientific research demonstration mode of practical experience for the understanding and justification of facts. Results: Gepag JC emerged in 2008 and, in 2014, was computerized with the Google Drive (R), in order to increase its scope and optimize the Groups meetings. From April to May 2014, the instrument was tested and adjusted, resulting in advancements. Final considerations: the advantages involved optimizing the time of meetings, facilitation of access to publications of interest to the Group and creating the database to support future research.Introdução: o Clube de Revistas (CR) é uma estratégia de ensino e aprendizagem desenvolvida por indivíduos que se encontram para discutir artigos científicos selecionados em periódicos. Objetivo: descrever a experiência da estratégia do CR no Grupo de Estudos e Pesquisas em Administração de Serviços de Saúde e Gerenciamento de Enfermagem (Gepag). Método: relato de experiência ou modalidade de investigação científica de demonstração de experiência prática para compreensão e fundamentação de fatos. Resultados: o CR do Gepag surgiu em 2008 e, em de 2014, foi informatizado com o Google Drive®, a fim de aumentar sua abrangência e otimizar as reuniões do grupo. De abril a maio de 2014, a ferramenta foi testada e ajustada, resultando em ganhos. Considerações finais: as vantagens envolveram a otimização do tempo das reuniões, a facilitação do acesso às publicações de interesse do grupo e a criação de banco de dados para subsidiar futuras pesquisas.Univ Fed Sao Paulo, Postgrad Program Nursing, Sao Paulo, BrazilUniv Fed Sao Paulo, Postgrad Program Nursing, Sao Paulo, BrazilWeb of Scienc

The 1988 Antarctic ozone monitoring Nimbus-7 TOMS data atlas

Because of the great environmental significance of ozone and to support continuing research at McMurdo, Syowa, and other Southern Hemisphere stations, the development of the 1988 ozone hole was monitored using data from the Nimbus-7 Total Ozone Mapping Spectrometer (TOMS) instrument, produced in near-real-time. This Atlas provides a complete set of daily polar orthographic projections of the TOMS total ozone measurements over the Southern Hemisphere for the period August 1 through November 17, 1988. Although total ozone in mini-holes briefly dropped below 150 DU in late August, the main ozone hole is seen to be much less pronounced than in 1987. Minimum values, observed in late September and early October 1988, were seldom less than 175 DU. Compared with the same period in 1987, when a pronounced ozone hole whose minimum value of 109 Dobson Units (DU) was the lowest total ozone ever observed, the 1988 ozone hole is displaced from the South Pole, opposing a persistent maximum with values consistently above 500 DU. Daily ozone values above selected Southern Hemisphere stations are presented, along with comparisons of the 1988 ozone distribution to that of other years

The 1989 Airborne Arctic Stratospheric Expedition Nimbus-7 TOMS data atlas

Over the past several years, world scientific attention was focused on the rapid and unanticipated decrease in the abundance of ozone over Antarctica during the Austral spring. A major aircraft campaign was conducted from December 1988 to February 1989 in response to the recently published Ozone Trends Panel Report which found that the largest decreases in Arctic ozone occurred during January to February at latitudes near the edge of the Arctic vortex. This atlas provides a complete set of TOMS ozone measurements over Europe and the North Atlantic for the duration of the experiment. These were the orbital TOMS measurements provided to the experimenters in near-real-time. In addition, a set of Northern Hemisphere TOMS ozone measurements for the period December 26, 1988 to March 20, 1989 is presented. A comparison of January and February 1989 mean ozone values to prior years is also presented

Nimbus-7 TOMS Antarctic ozone atlas: August - December 1990

Because of the great environmental significance of ozone and to support continuing research at the Antarctic and other Southern Hemisphere stations, the development of the 1990 ozone hole was monitored using data from the Nimbus-7 Total Ozone Mapping Spectrometer (TOMS) instrument, produced in near-real-time. This Atlas provides a complete set of daily polar orthographic projections of the TOMS total ozone measurements over the Southern Hemisphere for the period 1 Aug. through 31 Dec. 1990. The 1990 ozone hole developed in a manner similar to that of 1987 and 1989, reaching a comparable depth in early October. This was in sharp contrast to the much weaker hold of 1988. The 1990 ozone hole remained at polar latitudes as it filled in Nov., in contrast to other recent years when the hold drifted to mid-latitudes before disappearing. Daily ozone values above selected Southern Hemisphere stations are presented, along with comparisons of the 1990 ozone distribution to that of other years. A new calibration scheme (Version 6) was used to process 1990 ozone values, as well as to reprocess those of previous years

Chromomycin A2 Induces Autophagy in Melanoma Cells

The present study highlights the biological effects of chromomycin A2 toward metastatic melanoma cells in culture. Besides chromomycin A2, chromomycin A3 and demethylchromomycin A2 were also identified from the extract derived from Streptomyces sp., recovered from Paracuru Beach, located in the northeast region of Brazil. the cytotoxic activity of chromomycin A2 was evaluated across a panel of human tumor cell lines, which found IC50 values in the nM-range for exposures of 48 and 72 h. MALME-3M, a metastatic melanoma cell line, showed the highest sensitivity to chromomycin A2 after 48h incubation, and was chosen as a model to investigate this potent cytotoxic effect. Treatment with chromomycin A2 at 30 nM reduced cell proliferation, but had no significant effect upon cell viability. Additionally, chromomycin A2 induced accumulation of cells in G(0)/G(1) phase of the cell cycle, with consequent reduction of S and G(2)/M and unbalanced expression of cyclins. Chromomycin A2 treated cells depicted several cellular fragments resembling autophagosomes and increased expression of proteins LC3-A and LC3-B. Moreover, exposure to chromomycin A2 also induced the appearance of acidic vacuolar organelles in treated cells. These features combined are suggestive of the induction of autophagy promoted by chromomycin A2, a feature not previously described for chromomycins.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundacao Cearense de Apoio ao Desenvolvimento Cientifico e Tecnologico (FUNCAP-Programa Areas Estrategicas)Univ Fed Ceara, Inst Marine Sci, BR-60165081 Fortaleza, Ceara, BrazilUniv Fed Ceara, Dept Physiol & Pharmacol, BR-60430270 Fortaleza, Ceara, BrazilUniversidade Federal de São Paulo, Dept Marine Sci, BR-11030400 São Paulo, BrazilUniv Fed Ceara, Dept Organ & Inorgan Chem, BR-60021970 Fortaleza, Ceara, BrazilFdn MEDINA, Ctr Excelencia Invest Medicamentos Innovadores An, Granada 18016, SpainUniversidade Federal de São Paulo, Dept Marine Sci, BR-11030400 São Paulo, BrazilWeb of Scienc

High rates of undiagnosed leprosy and subclinical infection amongst school children in the Amazon Region

Leprosy in children is correlated with community-level factors, including the recent presence of disease and active foci of transmission in the community. We performed clinical and serological examinations of 1,592 randomly selected school children (SC) in a cross-sectional study of eight hyperendemic municipalities in the Brazilian Amazon Region. Sixty-three (4%) SC, with a mean age of 13.3 years (standard deviation = 2.6), were diagnosed with leprosy and 777 (48.8%) were seropositive for anti-phenolic glycolipid-I (PGL-I). Additionally, we evaluated 256 household contacts (HHCs) of the students diagnosed with leprosy; 24 (9.4%) HHC were also diagnosed with leprosy and 107 (41.8%) were seropositive. The seroprevalence of anti-PGL-I was significantly higher amongst girls, students from urban areas and students from public schools (p < 0.0001). Forty-five (71.4%) new cases detected amongst SC were classified as paucibacillary and 59 (93.6%) patients did not demonstrate any degree of physical disability at diagnosis. The results of this study suggest that there is a high rate of undiagnosed leprosy and subclinical infection amongst children in the Amazon Region. The advantages of school surveys in hyperendemic areas include identifying leprosy patients at an early stage when they show no physical disabilities, preventing the spread of the infection in the community and breaking the chain of transmission.CNPq [576425/2008-7]CNPqFAPESPAFAPESPASESPASESPAUFPAUFP

Soil profile, relief features and their relation to structure and distribution of Brazilian Atlantic rain forest trees

In tropical forests, the environmental heterogeneity can provide niche partitioning at local scales and determine the diversity and plant species distribution. Thus, this study aimed to investigate the variations of tree species structure and distribution in response to relief and soil profile features in a portion of the largest remnant of Brazilian Atlantic rain forest. All trees >= 5 cm diameter at breast height were recorded in two 0.99 ha plots. Topographic survey and a soil characterization were accomplished in both plots. Topsoil samples (0-20 cm) were taken from 88 quadrats and analyzed for chemical and particle size properties. Differences for both diversity and tree density were identified among three kinds of soils. A canonical correspondence analysis (CCA) indicated that the specific abundance varied among the three kinds of soils mapped: a shallow Udept - Orthent / Aquent gradient, probably due to differences in soil drainage. Nutrient content was less likely to affect tree species composition and distribution than relief, pH, Al3+, and soil texture. Some species were randomly distributed and did not show restriction to relief and soil properties. However, preferences in niche occupation detected in this study, derived from the catenary environments found, rise up as an important explanation for the high tree species diversity in tropical forests.FAPESPFAPESP [95/9626-0]UNESPUNESPCNPqCNPqCAPESCAPESUNESP Rio ClaroUNESP Rio Clar