Higher order forward spin polarizability

As a guideline for future experiments to extract the four (leading) spin polarizabilities of the nucleon, we have constructed the forward amplitude for polarized Compton scattering by dispersion integrals. These integrals have been saturated by recently measured helicity-dependent photoabsorption cross sections as well as predictions for pion photoproduction multipoles from several phenomenological descriptions and chiral perturbation theory. The comparison of these results corroborates the strategy to extract the spin polarizabilities by fitting them to polarized Compton data and fixing all higher order spin effects by dispersion relations based on pion photoproduction multipoles.Comment: 21 pages, 6 figures, 3 Tables; version to appear in Phys. Lett.

Impact of food retailer branding on expectation generation and liking

Abstract: Branding can influence sensory evaluation, however, the impact of food retailers from different tiers (premium, everyday and discount) remains undocumented. The aim of this project was to test whether food retailers generated different quality expectations and establish whether these impacted on sensory evaluation. Expected liking of 4 chocolate samples (private brand, premium, everyday and discount food retailer brands) was measured using a survey (n=199) and hedonic ratings (n=152) were obtained in blind and informed conditions. Seventy one of the 152 panelists were required to rate their expected liking prior to the informed hedonic test to assess whether stating expectations could influence subsequent liking. The premium food retailer and private brand generated similarly high quality expectations which resulted in significant disconfirmation although a significant response shift was only observed for the private brand when expectations were measured. In contrast, the everyday and discount food retailers generated lower expectations which aligned well with the sensory experience. Practical applications: Although established private brands are still perceived as the gold standard; premium food retailers can also generate high expectations and there is a clear hierarchy of expectations between food retailers' tiers. In spite of this, branding had a modest impact on sensory evaluation compared to actual product quality with partial assimilation observed only for the private brand. Food retailers should continue to develop their product quality to carry on improving their brand image. Asking panelists to state their expectations just prior to the informed hedonic testing could result in self-induced suggestion error. It is recommended that expectations and informed liking are captured sufficiently far apart when using the same panelists

Planeamiento estratégico digital para la Organización Matchcota

Matchcota Perú es una organización sin fines de lucro que vela por una calidad de vida para perros y gatos, motivo por el cual, fomenta la adopción responsable, en coordinación con albergues aliados, así como el apadrinamiento y donaciones para el sustento de los mismos a través de su sitio web. Esta organización, en los últimos meses, ha visto un decrecimiento de adopciones, hecho que, intuimos y posteriormente afirmamos, se debe a que existen muchos interesados en la adopción de mascotas, pero estos no consideran a Matchcota como un medio para dicho fin, ya que no la conocen y no han escuchado de esta. Por ello, el objetivo del presente trabajo es dar una solución para incrementar el tráfico, el nivel de engagement y las adopciones de Matchcota con un presupuesto mínimo. Con este fin, realizamos investigación secundaria y primaria, resaltando de esta la implementación de la metodología Design Thinking, efectiva para conseguir insights potentes a partir de un conocimiento profundo del público objetivo seleccionado: jóvenes y adultos entre 25 y 55 años de Lima Metropolitana prestos a influenciar o aprobar la adopción de una mascota en casa. Como resultado, estructuramos una campaña transmedia para medios digitales, en donde Facebook, Instagram y TikTok son las plataformas ideales en donde mascotas adoptadas y sus dueños son los aliados estratégicos perfectos para alcanzar tanto el propósito de Matchcota como el objetivo de la campaña.Matchcota Peru is a non-profit organization that promotes a better quality of life for dogs and cats by encouraging responsible adoption, together with allied shelters, as well as sponsorships and donations who support them through their own website. In the last few months adoptions have decreased, a fact that we believed and later confirmed is due to the fact that even though there are many people interested in adopting pets, they do not consider Matchocta as an option to make it happen, as they have not heard of it. Therefore, the objective of this campaign is to offer a solution to increase traffic, the level of engagement and adoption to this organization with a minimum budget. For this we carry out secondary and primary research highlighting the Design Thinking method for this implementation, effective in achieving powerful insights based on in-depth knowledge of the specific target audience: young people and adults between 25 and 55 years from Metropolitan Lima, who are likely to influence pet adoptions at home or approve the adoption of a new pet. For this we structured a transmedia campaign for digital media, where Facebook, Instagram and TikTok are ideal platforms for pets and their owners to become perfect strategic allies to achieve Matchcota’s purpose and the objective of the campaign.Trabajo de investigació

Improving cardiovascular magnetic resonance access in low- and middle-income countries for cardiomyopathy assessment: rapid cardiovascular magnetic resonance

AIMS: To evaluate the impact of a simplified, rapid cardiovascular magnetic resonance (CMR) protocol embedded in care and supported by a partner education programme on the management of cardiomyopathy (CMP) in low- and middle-income countries (LMICs). METHODS AND RESULTS: Rapid CMR focused particularly on CMP was implemented in 11 centres, 7 cities, 5 countries, and 3 continents linked to training courses for local professionals. Patients were followed up for 24 months to assess impact. The rate of subsequent adoption was tracked. Five CMR conferences were delivered (920 attendees-potential referrers, radiographers, reporting cardiologists, or radiologists) and five new centres starting CMR. Six hundred and one patients were scanned. Cardiovascular magnetic resonance indications were 24% non-contrast T2* scans [myocardial iron overload (MIO)] and 72% suspected/known cardiomyopathies (including ischaemic and viability). Ninety-eighty per cent of studies were of diagnostic quality. The average scan time was 22 ± 6 min (contrast) and 12 ± 4 min (non-contrast), a potential cost/throughput reduction of between 30 and 60%. Cardiovascular magnetic resonance findings impacted management in 62%, including a new diagnosis in 22% and MIO detected in 30% of non-contrast scans. Nine centres continued using rapid CMR 2 years later (typically 1-2 days per week, 30 min slots). CONCLUSIONS: Rapid CMR of diagnostic quality can be delivered using available technology in LMICs. When embedded in care and a training programme, costs are lower, care is improved, and services can be sustained over time. KEY QUESTION: KEY FINDING: TAKE-HOME MESSAGE

Treating age-related multimorbidity:the drug discovery challenge

Patients with multimorbidities have shorter life expectancy and their clinical management is more complex and expensive for healthcare systems currently focused on treating single diseases. Given that age is the major risk factor for multimorbidity, the challenge of treating these patients will only increase in coming years. Here, we review the case for targeting the core processes that drive the ageing phenotype as a novel pharmaceutical approach to multimorbidity. There is growing evidence that targeting ageing mechanisms can reduce or delay age-related diseases in animal models, and the first reports of clinical trials are now appearing. Although these trials currently focus on repurposed drugs, we propose several novel targets that would more specifically target ageing processes and thereby reduce multimorbidity and polypharmacy in future generations

Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials

Stromal tumor-infiltrating lymphocytes (sTILs) are a potential predictive biomarker for immunotherapy response in metastatic triple-negative breast cancer (TNBC). To incorporate sTILs into clinical trials and diagnostics, reliable assessment is essential. In this review, we propose a new concept, namely the implementation of a risk-management framework that enables the use of sTILs as a stratification factor in clinical trials. We present the design of a biomarker risk-mitigation workflow that can be applied to any biomarker incorporation in clinical trials. We demonstrate the implementation of this concept using sTILs as an integral biomarker in a single-center phase II immunotherapy trial for metastatic TNBC (TONIC trial, NCT02499367), using this workflow to mitigate risks of suboptimal inclusion of sTILs in this specific trial. In this review, we demonstrate that a web-based scoring platform can mitigate potential risk factors when including sTILs in clinical trials, and we argue that this framework can be applied for any future biomarker-driven clinical trial setting

Broad-Spectrum Drugs Against Viral Agents

Development of antivirals has focused primarily on vaccines and on treatments for specific viral agents. Although effective, these approaches may be limited in situations where the etiologic agent is unknown or when the target virus has undergone mutation, recombination or reassortment. Augmentation of the innate immune response may be an effective alternative for disease amelioration. Nonspecific, broad-spectrum immune responses can be induced by double-stranded (ds)RNAs such as poly (ICLC), or oligonucleotides (ODNs) containing unmethylated deocycytidyl-deoxyguanosinyl (CpG) motifs. These may offer protection against various bacterial and viral pathogens regardless of their genetic makeup, zoonotic origin or drug resistance

Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials

Stromal tumor-infiltrating lymphocytes (sTILs) are a potential predictive biomarker for immunotherapy response in metastatic triple-negative breast cancer (TNBC). To incorporate sTILs into clinical trials and diagnostics, reliable assessment is essential. In this review, we propose a new concept, namely the implementation of a risk-management framework that enables the use of sTILs as a stratification factor in clinical trials. We present the design of a biomarker risk-mitigation workflow that can be applied to any biomarker incorporation in clinical trials. We demonstrate the implementation of this concept using sTILs as an integral biomarker in a single-center phase II immunotherapy trial for metastatic TNBC (TONIC trial, NCT02499367), using this workflow to mitigate risks of suboptimal inclusion of sTILs in this specific trial. In this review, we demonstrate that a web-based scoring platform can mitigate potential risk factors when including sTILs in clinical trials, and we argue that this framework can be applied for any future biomarker-driven clinical trial setting