6-[(E)-2-Phenyl­vin­yl]-1H-indole

The title compound, C16H13N, is essentially planar [maximum deviation from the least-squares plane = 0.081 (3) Å], with a dihedral angle of 1.65 (13)° between the planes of the indole and benzene rings. In the crystal, there are no significant inter­molecular π–π inter­actions [minimum ring centroid–centroid separation = 4.217 (5) Å]

(2′-Amino-4,4′-bi-1,3-thia­zol-2-aminium-κ2 N,N′)aqua­[citrato(4−)-κ3 O,O′,O′′)chromium(III) dihydrate

In the title compound, [Cr(C6H7N4S2)(C6H4O7)(H2O)]·2H2O, the CrIII atom is in a distorted octa­hedral environment, coordinated by one water mol­ecule, two N atoms from a protonated diamino­bithia­zole ligand and three O atoms from a citrate(4−) anion. The complex is zwitterionic, with the H atom from the uncoordinated carboxyl­ate group of the citrate anion transferred to one amino group of the diamino­bithia­zole ligand. O—H⋯O and N—H⋯O hydrogen bonds link the complexes into layers including the two uncoordinated water mol­ecules

3-Chloro-5-(trifluoro­meth­yl)pyridin-2-amine

In the title compound, C6H4ClF3N2, an inter­mediate in the synthesis of the fungicide fluazinam, the F atoms of the trifluoro­methyl group are disordered over two sites in a 0.683 (14):0.317 (14) ratio. In the crystal structure, centrosymmetric dimers arise from pairs of N—H⋯N hydrogen bonds

Tunable biphasic drug release from ethyl cellulose nanofibers fabricated using a modified coaxial electrospinning process

This manuscript reports a new type of drug-loaded core-shell nanofibers that provide tunable biphasic release of quercetin. The nanofibers were fabricated using a modified coaxial electrospinning process, in which a polyvinyl chloride (PVC)-coated concentric spinneret was employed. Poly (vinyl pyrrolidone) (PVP) and ethyl cellulose (EC) were used as the polymer matrices to form the shell and core parts of the nanofibers, respectively. Scanning and transmission electron microscopy demonstrated that the nanofibers had linear morphologies and core-shell structures. The quercetin was found to be present in the nanofibers in the amorphous physical status, on the basis of X-ray diffraction results. In vitro release profiles showed that the PVP shell very rapidly freed its drug cargo into the solution, while the EC core provided the succedent sustained release. Variation of the drug loading permitted the release profiles to be tuned