Positive Measure Spectrum for Schroedinger Operators with Periodic Magnetic Fields

We study Schroedinger operators with periodic magnetic field in Euclidean 2-space, in the case of irrational magnetic flux. Positive measure Cantor spectrum is generically expected in the presence of an electric potential. We show that, even without electric potential, the spectrum has positive measure if the magnetic field is a perturbation of a constant one.Comment: 17 page

A discrete methodology for controlling the sign of curvature and torsion for NURBS

This paper develops a discrete methodology for approximating the so-called convex domain of a NURBS curve, namely the domain in the ambient space, where a user-specified control point is free to move so that the curvature and torsion retains its sign along the NURBS parametric domain of definition. The methodology provides a monotonic sequence of convex polyhedra, converging from the interior to the convex domain. If the latter is non-empty, a simple algorithm is proposed, that yields a sequence of polytopes converging uniformly to the restriction of the convex domain to any user-specified bounding box. The algorithm is illustrated for a pair of planar and a spatial Bézier configuration

CARINA oxygen data in the Atlantic Ocean

In the CARINA (Carbon dioxide in the Atlantic Ocean) project, a new dataset with many previously unpublished hydrographic data from the Atlantic, Arctic and Southern Ocean was assembled and subjected to careful quality control (QC) procedures. Here, we present the dissolved oxygen measurements in the Atlantic region of the dataset and describe in detail the secondary QC procedures that aim to ensure that the data are internally consistent. This is achieved by a cross-over analysis, i.e. the comparison of deep ocean data at places that were sampled by different cruises at different times. Initial adjustments to the individual cruises were then determined by an inverse procedure that computes a set of adjustments that requires the minimum amount of adjustment and at the same time reduces the offsets in an optimal manner. The initial adjustments were then reviewed by the CARINA members, and only those that passed the following two criteria were adopted: (i) the region is not subject to substantial temporal variability, and (ii) the adjustment must be based on at least three stations from each cruise. No adjustment was recommended for cruises that did not fit these criteria. The final CARINA-Oxygen dataset has 103414 oxygen samples from 9491 stations obtained during 98 cruises covering three decades. The sampling density of the oxygen data is particularly good in the North Atlantic north of about 40° N especially after 1987. In contrast, the sample density in the South Atlantic is much lower. Some cruises appear to have poor data quality, and were subsequently omitted from the adjusted dataset. Of the data included in the adjusted dataset, 20% were adjusted with a mean adjustment of 2%. Due to the achieved internal consistency, the resulting product is well suited to produce an improved climatology or to study long-term changes in the oxygen content of the ocean. However, the adjusted dataset is not necessarily better suited than the unadjusted data to address questions that require a high level of accuracy, such as the computation of the saturation state

Induced Gamma-band Activity Elicited by Visual Representation of Unattended Objects

Peer reviewedPostprin

Off-the-Shelf Allogeneic T Cell Therapies for Cancer: Opportunities and Challenges Using Naturally Occurring "Universal" Donor T Cells.

Chimeric antigen receptor (CAR) engineered T cell therapies individually prepared for each patient with autologous T cells have recently changed clinical practice in the management of B cell malignancies. Even though CARs used to redirect polyclonal T cells to the tumor are not HLA restricted, CAR T cells are also characterized by their endogenous T cell receptor (TCR) repertoire. Tumor-antigen targeted TCR-based T cell therapies in clinical trials are thus far using "conventional" αβ-TCRs that recognize antigens presented as peptides in the context of the major histocompatibility complex. Thus, both CAR- and TCR-based adoptive T cell therapies (ACTs) are dictated by compatibility of the highly polymorphic HLA molecules between donors and recipients in order to avoid graft-versus-host disease and rejection. The development of third-party healthy donor derived well-characterized off-the-shelf cell therapy products that are readily available and broadly applicable is an intensive area of research. While genome engineering provides the tools to generate "universal" donor cells that can be redirected to cancers, we will focus our attention on third-party off-the-shelf strategies with T cells that are characterized by unique natural features and do not require genome editing for safe administration. Specifically, we will discuss the use of virus-specific T cells, lipid-restricted (CD1) T cells, MR1-restricted T cells, and γδ-TCR T cells. CD1- and MR1-restricted T cells are not HLA-restricted and have the potential to serve as a unique source of universal TCR sequences to be broadly applicable in TCR-based ACT as their targets are presented by the monomorphic CD1 or MR1 molecules on a wide variety of tumor types. For each cell type, we will summarize the stage of preclinical and clinical development and discuss opportunities and challenges to deliver off-the-shelf targeted cellular therapies against cancer

Disappearing Pulses in Vela X-1

We present results from a 20 h RXTE observation of Vela X-1, ncluding a peculiar low state of a few hours duration, during which the pulsation of the X-ray emission ceased, while significant non-pulsed emission remained. This ``quiescent state'' was preceded by a ``normal state'' without any unusual signs and followed by a ``high state'' of several hours of increased activity with strong, flaring pulsations. while there is clear spectral evolution from the normal state to the low state, the spectra of the following high state are surprisingly similar to those of the low state.Comment: 5 pages, 5 figures, Proceedings of the 5th Compton Symposium, AIP, in pres

Discovery of a Cyclotron Resonance Scattering Feature in the X-ray Spectrum of XTE J1946+274

Observations of the transient accreting pulsar XTE J1946+274 made with the Rossi X-ray Timing Explorer during the course of the 1998 September-November outburst, reveal a cyclotron resonance scattering feature (or "cyclotron line") in the hard X-ray spectrum near 35 keV. We determine a centroid energy of 36.2 +0.5/-0.7 keV, which implies a magnetic field strength of 3.1(1+z)x10^12 G, where z is the gravitational redshift of the scattering region. The optical depth, Tau = 0.33 +0.07/-0.06, and width, sigma = 3.37 +0.92/-0.75 keV, are typical of known cyclotron lines in other pulsars. This discovery makes XTE J1946+274 one of thirteen pulsars with securely detected cyclotron lines resulting in direct magnetic field measurements.Comment: Five pages including four postscript figures and two tables. Uses emulateapj5. Published in ApJ Letters: http://adsabs.harvard.edu/cgi-bin/nph-bib_query?bibcode=2001ApJ...563L..35