11 research outputs found
InterAACT: A multicentre open label randomised phase II advanced anal cancer trial of cisplatin (CDDP) plus 5-fluorouracil (5-FU) vs carboplatin (C) plus weekly paclitaxel (P) in patients (pts) with inoperable locally recurrent (ILR) or metastatic treatment naïve disease - An International Rare Cancers Initiative (IRCI) trial
Whilst advanced squamous cell carcinoma of the anal canal (SCCA) is a rare disease incidence has risen by 2%/year for the past decade. There is no consensus on management of these pts who generally have a poor overall survival (OS) and to date no randomised trial has been completed. The combination of fluoropyrimidine /platinum agents is often considered standard 1st line therapy whilst taxanes have shown activity. We conducted a randomised phase II study to establish a standard of care
Early opening history of the North Atlantic ? I. Structure and origin of the Faeroe?Shetland Escarpment
Marine geophysical surveys show that the Escarpment is the buried feather-edge of a thick pile of flood basalts of early Eocene age, overlying a thinner, more widespread layer of basalts of late Palaeocene age. The Escarpment does not, therefore, define the continent—ocean boundary in the southern Norwegian Sea, but instead marks the contemporary shoreline separating terrestrially erupted basalt flows in the north from a restricted shallow-water shelf to the south. The basalts overlie 5–6 km of Mesozoic sediments, which have completely buried a large conical flat-topped seamount of similar dimensions to Anton Dohrn and Rosemary Bank. We call this newly postulated body the Brendan seamount. The Mesozoic sediments are at least as old as early Cretaceous in age, therefore precluding the possibility that the mid-Cretaceous seafloor spreading episode (supposed by some to have created the Rockall Trough) could have also created the thin crust inferred to underlie the Faeroe—Shetland Trough and Møre Basin