Behaviour of the Blazar CTA 102 during two giant outbursts

Blazar CTA 102 underwent exceptional optical and high-energy outbursts in 2012 and 2016-2017. We analyze its behaviour during these events, focusing on polarimetry as a tool that allows us to trace changes in the physical conditions and geometric configuration of the emission source close to the central black hole. We also use Fermi gamma-ray data in conjunction with optical photometry in an effort to localize the origin of the outbursts.AST-1615796 - Boston Universit

Near-threshold production of a0(980)a_0(980)-mesons in πN\pi N and NN collisions and a0/f0a_0/f_0-mixing

We consider near-threshold $a_0(980)$-meson production in $\pi N$ and $NN$ collisions. An effective Lagrangian approach with one-pion exchange is applied to analyze different contributions to the cross section for different isospin channels. The Reggeon exchange mechanism is also evaluated for comparison. The results from $\pi N$ reactions are used to calculate the contribution of the $a_0$ meson to the cross sections and invariant $K \bar K$ mass distributions of the reactions $pp\to pn K^+\bar K^0$ and $pp\to pp K^+K^-$. It is found that the experimental observation of $a_0^+$ mesons in the reaction $pp\to pn K^+\bar K^0$ is much more promising than the observation of $a_0^0$ mesons in the reaction $pp\to pp K^+K^-$. Effects of isospin violation in the reactions $pN \to d a_0$, $pd \to \mathrm{^3He/^3H} a_0$, and $dd \to \mathrm{^4He} a_0$, which are induced by $a_0(980)$--$f_0(980)$ mixing, are also analyzed.Comment: 43 pages, including 16 eps figures, to be bublished in Phys. Atom. Nucl. (Yad. Fiz.) vol. 65, No. 11 (2002

Aspects of a0-f0 mixing in the reaction pn->da0

Some aspects of a0-f0 mixing effects in the reaction ${\vec p} n\to da^0_0$ with perpendicular polarized proton beam are discussed. An angular--asymmetry parameter $A$ is defined to study those effects. It is shown that, for energies close to the production threshold, the angular--asymmetry parameter $A(\theta, \phi)$ is proportional to the a0-f0 mixing amplitude for arbitrary polar and azimuthal angles $\theta$ and $\phi$ of the outgoing $a_0$ meson. This statement is also valid for arbitrary energies, but then only at polar angles $\theta=0^0$ and $\theta=90^0$. The mass dependence of the differential cross section $d\sigma/dm_{\pi^0\eta}$ in the reaction $pn\to d\pi^0\eta$ in the presence of \mix mixing is also discussed.Comment: 17 pages, 3 Figure

t-3-Ethyl-r-2,c-6-bis­(4-methoxy­phen­yl)-1-nitro­sopiperidin-4-one

In the title mol­ecule, C21H24N2O4, the piperidine ring adopts a distorted boat conformation with the ethyl substituent in the axial position. The dihedral angle between the two benzene rings is 70.25 (9)°. An intra­molecular C—H⋯O inter­action is observed. In the crystal, mol­ecules are linked into a chain along the c axis by C—H⋯O hydrogen bonds and the chains are linked via weak C—H⋯π inter­actions

The roles of vitamin D in the prevention and the therapy of male infertility

The results of fundamental and clinical studies show the importance of providing males with vitamin D in order to (1) assist the formation of the testicles, (2) maintain the steroid-synthesizing and other functions of the testicles, (3) maintain the functioning of the spermatozoa and, in general, maintain the male fertility

Features of compiling metabolic correction programs for professional athletes and the possibility of their optimization using digital technologies

To compile a personalized program for correcting the metabolism of a professional athlete, it is necessary to take into account many factors, including age, gender, sports specialization, individual characteristics, the pathologies in the anamnesis, the stage of the athlete’s training cycle, etc. When drawing up such programs for athletes of sports national teams of the Russian Federation, a scheme for assessing the characteristics of the athlete’s body is used, the basis for which is information obtained during in-depth medical examinations of athletes conducted on the basis of clinics of the FMBA Russia. To improve the quality of personalized programs of metabolic correction in the future, it is possible to use professionally oriented reference intervals of laboratory blood parameters, as well as the results of genetic screening based on the strategy of complete exomic sequencing of the athlete’s genome. One of the ways to increase the efficiency of metabolic correction of professional athletes is the introduction of modern information technologies and the development of a modern information system based on them. The introduction of such an information system will increase the speed of primary processing of initial information about the health status of the athlete and the peculiarities of his metabolic processes, as well as partially automate the formation of individualized recommendations regarding the diet and hydratation, and the choice of metabolic correction at various stages of the sports season

Phenotypic heterogeneity and diagnostic features of transthyretin amyloidosis with polyneuropathy

Transthyretin amyloidosis (ATTR-amyloidosis) is a systemic progressive fatal disease, for which a modifying therapy has recently been proposed that delays the progression of the disease and improves the patient’s quality of life. The delay in the diagnosis of ATTR-amyloidosis is associated with the heterogeneity of the manifestations of the disease, as well as insufficient awareness of doctors of different specialties about the disease. A review of recent studies on the symptomatology, diagnosis, molecular genetic characteristics of ATTR-amyloidosis and the most common forms of the disease with the predominant involvement of peripheral nerves and the heart, as well as the kidneys, gastrointestinal tract, and eyes is presented. The international consensus recommendations for the diagnosis of suspected ATTR-amyloidosis using modern methods that facilitate early and accurate diagnosis are discussed. The reasons and the most frequent misdiagnoses of ATTR-amyloidosis, which also lead to a delay in the timely appointment of therapy, are considered. Molecular genetic testing should be considered early in the evaluation of a patient with unexplained peripheral neuropathy and cardiomyopathy. A diagnostic algorithm based on the initial symptoms and manifestations of the cardiovascular and nervous systems facilitates the identification of a patient with clinical suspicion of ATTR-amyloidosis by the general practitioner. Early diagnosis is critically important for patients with ATTR polyneuropathy, since the early prescription of Vyndaqel (tafamidis), registered in the Russian Federation in 2017, allows a significant clinical effect to be obtained. Timely administration of Vyndaqel significantly slows down the progression of the disease, improves the prognosis and quality of life in patients with ATTR polyneuropathy

A Digital Model of Full-Cycle Training Based on the Zettelkasten and Interval Repetition System

The study aims to propose and validate a new digital model based on the Zettelkasten and interval repetition system for comprehensive and full-cycle training of the students. The core idea is to enhance the learning experience and effectiveness of the given training course by enhancing the student's attention during the learning and long-term information retention. In pursuit of the aforementioned research aim, the study incorporates a quantitative research methodology by combining experiments and a survey. In particular, the effectiveness of the proposed model was assessed via an achievement assessment involving two groups of students and assessing their scores on the same test. This was followed by a metacognitive awareness survey of the two groups to investigate their perceived understanding and performance (with and without the use of a model). The proposed model was found to be effective in enhancing the learning experience and effectiveness of the students on the training course. The Zettelkasten facilitates the management of the student's attention, while the interval repetition system contributes to increased retention. The students that used this model in their learning and preparation scored better than their peers. Also, they reported a significantly higher understanding and awareness of their learning than their peers. The model can be incorporated into the learning process or the provision of training courses to the students. This study is the first to suggest the integration of Zettelkasten and the interval repetition system into one learning model for the students. The article proposes a practical model that can be incorporated by teachers to improve the learning effectiveness of their students. This article has some limitations as well that must be acknowledged. Doi: 10.28991/ESJ-2023-SIED2-01 Full Text: PD