Sinteza i karakterizacija uns-cis-(etilendiamin-N,N'-di-3-propionato) (N-alkiletilendiamin) kobalt(III) kompleksa

Three octahedral cobalt(III) complexes of the general formula uns-cis-[Co(eddp)(R-en)]Cl . H2O, where eddp = the tetradentate ONNO-type ligand ethylenediamine-N,N'-di-3-propionate and R-en = a bidentate NN-type ligand, either N-methyl, N-ethyl or N-iso-propylethylenediamine. The complexes were prepared by the reaction of sodium uns-cis-(ethylenediamine-N,N'-di-3-propionato)(carbonato)cobalt(III)dihydrate with the corresponding diamine. They were isolated chromatographically and characterized by elemental analysis, infrared and electronic absorption spectroscopy.U ovom radu su sintetisana i okarakterisana tri oktaedarska kobalt(III) kompleksa opšte formule uns-cis-[Co(eddp) (R-en)]Cl∙2H2O, gde je eddp tetradentatni ONNO- tip liganda etilendiamin-N,N'-di-3-propionat, a R-en bidentatni NN ligand, N-metil, N-etil ili N-izopropiletilendidamin. Kompleksi su sintetisani polazeći od uns-cis- natrijum(etilendiamin-N,N'-di-3-propionato)(karbonato)kobaltat(III)-dihidrata i odgovarajućih diamina, izolovani hromatografski i okarakterisani elementalnom analizom, infracrvenom i elektronsko-apsorpcionom spektroskopijom

The New Ruthenium(Ii)-Bipyridyl Complex with O,O '-Diethyl-(S,S)Ethylenediamine-N,N '-Di-2-(3-Cyclohexyl)Propanoate: Synthesis and Characterization

The new bipyridyl complex of ruthenium(II) with O, O'-diethyl-(S, S)-ethylenediamine- N, N'-di- 2(3-cyclohexyl) propanoate was synthesized. The reaction of cis-[RuCl2(bpy)(2)] and its ligand was performed in water/ethanol solution, in the presence of lithium hydroxide, under reflux. After the addition of ammonium hexafluorophosphate, the complex was precipitated. The complex, cis-[Ru(bpy)(2)L](PF6)(2), was characterized by H-1 and C-13 NMR, UV-Vis, IR spectroscopy, ESI-MS spectrometry and elemental analysis. Results indicate an octahedral geometry of the complex, with N, N'-coordinated O, O'- diethyl-(S, S)ethylenediamine-N, N'-di- 2-(3-cyclohexyl) propanoate. Complexes of this type are particularly important in terms of potential cytotoxicity and application in photodynamic therapy. Using this therapy, many side effects can be reduced, which may allow the administration of higher drug dosages

Supplementary data for article: Poljarević, J.; Grgurić-Šipka, S.; Kaluđerović, G. N.; Sabo, T. Dibromido[(S,S)-Ethylenediamine-N,N ’-Di-2-(3-Cyclohexyl)Propanoato]Platinum(IV): Synthesis, Characterization, and DFT Calculations. Journal of Coordination Chemistry 2011, 64 (6), 1016–1022. https://doi.org/10.1080/00958972.2011.560940

Supplementary material for: [https://doi.org/10.1080/00958972.2011.560940]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/1160

In vivo ispitivanje enzimske aktivnosti nekih Ru(II) jedinjenja sa N-alkilfenotiazinima

The purpose of the present study was to investigate and compare the effects of two ruthenium complexes with trifl uoperazine on acethylcholinesterase enzyme activity and lactate dehydrogenase levels in vivo under physiological conditions in rats blood. Complexes 1 and 2 showed positive effects on acethylcholinesterase at all doses and did not disturb its normal activity. Total LDH activity was inhibited in the presence of both complexes, but Ru(II) complexes showed different effects on the activity of LDH isoenzymes. The activities of LDH1 and LDH2 isoenzymes were decreased in all applied doses of the complex 2, while the activity of LDH2 reduced using complex 1 in the same doses. Results of the present study suggest the neuro-and cardio protective potential of oral administration of complexes 1 and 2, as non-toxic compounds under physiological conditions. These protective effects are the result of their potent antioxidant activity.Cilj ovog rada je da se ispitaju i uporede efekti dva kompleksa rutenijuma sa trifluoperazinom na aktivnost enzima acetilholinesteraze i laktat-dehidrogenase in vivo pod fiziološkim uslovima u krvi pacova. Kompleksi 1 i 2 pokazali su pozitivan efekat na aktivnost acetiholinesteraze u svim primenjenim dozama. Ukupna aktivnost LDH je inhibirana u prisustvu oba kompleksa, ali kompleksi Ru(II) pokazuju različite rezultate na izoenzimske oblike ovog enzima. Aktivnosti izoenzima LDH1 i LDH2 su smanjene u svim primenjenim dozama kompleksa 2, dok kompleks 1 smanjuje aktivnost samo izoenzima LDH2 u tim istim koncentracijama. Rezultati prikazanog istraživanja ukazuju na neuro - i kardio zaštitni potencijal oralne primene kompleksa 1 i 2, kao netoksičnih jedinjenja pod fiziološkim uslovima, indukovano preko njihovog snažnog antioksidativnog efekta

Supplementary data for article: Poljarević, J.; Grgurić-Šipka, S.; Kaluđerović, G. N.; Sabo, T. Dibromido[(S,S)-Ethylenediamine-N,N ’-Di-2-(3-Cyclohexyl)Propanoato]Platinum(IV): Synthesis, Characterization, and DFT Calculations. Journal of Coordination Chemistry 2011, 64 (6), 1016–1022. https://doi.org/10.1080/00958972.2011.560940

Supplementary material for: [https://doi.org/10.1080/00958972.2011.560940]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/1160

Supplementary data for article: Nikolić, S.; Ćirić, I.; Roller, A.; Lukeš, V.; Arion, V. B.; Grgurić-Šipka, S. Conversion of Hydrazides into: N, N ′-Diacylhydrazines in the Presence of a Ruthenium(II)-Arene Complex. New Journal of Chemistry 2017, 41 (14), 6857–6865. https://doi.org/10.1039/c7nj00965h

Supplementary material for: [https://doi.org/10.1039/c7nj00965h]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/2485]Related to accepted version: [http://cherry.chem.bg.ac.rs/handle/123456789/3124

Supplementary data for article: Poljarević, J.; Krstić, M.; Grgurić-Šipka, S.; Sovilj, S. P.; Misic, D. R.; Sabo, T. Platinum(IV) Complexes with N-Alkylphenothiazines: Synthesis, Characterization, and Antibacterial Activity. Journal of Coordination Chemistry 2013, 66 (21), 3760–3769. https://doi.org/10.1080/00958972.2013.851788

Supplementary material for: [https://doi.org/10.1080/00958972.2013.851788]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/1452

Supplementary data for article: Misirlić Denčić, S.; Poljarević, J.; Isakovic, A. M.; Marković, I.; Sabo, T. J.; Grgurić-Šipka, S. Antileukemic Action of Novel Diamine Pt(II) Halogenido Complexes: Comparison of the Representative Novel Pt(II) with Corresponding Pt(IV) Complex. Chemical Biology and Drug Design 2017, 90 (2), 262–271. https://doi.org/10.1111/cbdd.12945

Supporting information for: [https://doi.org/10.1111/cbdd.12945]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/2483]Related to accepted version: [http://cherry.chem.bg.ac.rs/handle/123456789/3120

Editorial: The Golden Future in Medicinal Chemistry: Perspectives and Resources From Old and New Gold-Based Drug Candidates

Editorial: The Golden Future in Medicinal Chemistry: Perspectives and Resources From Old and New Gold-Based Drug Candidate