The relationship between body mass index (BMI) and sedentary behavior is mediated by negative peer interaction in boys

To determine if self-reported negative social interaction mediates the relationship between sedentary behavior and body mass index (BMI) percentile in boys. Twelve overweight/obese (≥85th BMI percentile) and 14 non-overweight (\u3c85th BMI percentile) boys (10.5 ± 1.5 years old) completed surveys assessing overt peer victimization and relational victimization. Children were individually given access to a gymnasium with physical activity equipment and sedentary alternatives for 30 minutes. Children could play with the equipment in any pattern they wished and the amount of time allocated to sedentary activities (sitting time) was recorded. Overt and relational victimization were moderately and positively associated with BMI percentile (r ≥ 0.40, p ≤ 0.04) and sitting time (r ≥ 0.40, p ≤ 0.05) and sitting time was positively associated with BMI percentile (r = 0.4, p = 0.05). After controlling for overt and relational victimization the correlation between sitting time and BMI percentile was non-significant (r ≤ 0.28, p ≥ 0.18). The positive relationship between BMI percentile and sedentary behavior was mediated by measures of negative social interaction

An Ancient Wolf, Canus lupus, Den and Associated Human Activity in the Southwestern Yukon Territory

The recovery of an ancient hunting artifact in an active Wolf den indicates that Wolf denning sites may be reused for many centuries. It also suggests that traditional practices of predator management by humans may have great antiquity

Impact of Activity Monitoring on Physical Activity, Sedentary Behavior, and Body Weight during the COVID-19 Pandemic

Decreases in individuals\u27 physical activity and increases in sedentary behavior and bodyweight have been reported during the COVID-19 pandemic. The present study assessed the ability of physical activity monitoring, which may promote physical activity and discourage sedentary behavior, to mitigate these negative outcomes. An evaluation of university samples ( N = 404, 40.5 ± 15.4 years) of self-reported physical activity, sedentary behavior, and bodyweight prior to the closure of campus due to the pandemic in March of 2020 and again at the time of the survey administration (May-June 2020) during pandemic-related restrictions was performed. Participants also reported whether they did ( n = 172) or did not ( n = 232) regularly use physical activity monitoring technology. While physical activity was unchanged during the pandemic ( p ≥ 0.15), participants significantly increased sitting by 67.8 ± 156.6 min/day and gained 0.64 ± 3.5 kg from pre-campus to post-campus closure ( p \u3c 0.001). However, the use of activity monitoring did not moderate these changes. In conclusion, while physical activity was not affected, participants reported significant increases in sedentary behavior and bodyweight during the COVID-19 pandemic. These changes occurred regardless of whether participants regularly used physical activity monitoring or not

Multidisciplinary Investigations of Alpine Ice Patches in Southwest Yukon, Canada: Paleoenvironmental and Paleobiological Investigations

Since the discovery of dung-rich alpine ice patches in southwest Yukon in 1997, continuing multidisciplinary studies have provided a unique window on the biology, climate, and hunting activity in this region over much of the Holocene. Aerial surveys have identified 72 ice patches of variable size, and 65 patches have been ground-surveyed for organic remains. Of these, 35 yielded an abundance of biological specimens, including caribou and other rare large mammal remains, mummified small mammals and birds, and artifacts spanning 8000 years. The dung provides pollen and plant macrofossils for analysis and paleoenvironmental reconstruction, as well as dietary, genetic, and parasitic information. Stratigraphically controlled sampling of dung within ice layers has yielded a geochronology placing their formation as early as 8300 to 8000 years BP. Ice patch formation was nearly continuous except for an interval between 6700 and 4700 years BP and another between 1440 and 1030, when warm or dry conditions (or both) resulted in no net ice accumulation. Resumption of ice accumulation over the following 500 years likely culminated in the Little Ice Age. The size of the ice patches during this period is made evident by a lichen-free zone that haloes each patch. More recently, interpretation of air photos from 1946 to 2001 has found a significant reduction in ice patch dimensions. Daily temperature records for Whitehorse (1942-2001) were used to calculate melting degree-day values that account for a large part of the variation in ice patch size, indicating that while considerable melting has likely occurred since the end of the Little Ice Age, the ice patches are highly sensitive to decadal changes in temperature.Depuis la découverte de plaques de glace alpines riches en excréments d'animaux dans le sud-ouest du Yukon en 1997, des études multidisciplinaires continues offrent une fenêtre unique sur la biologie, le climat et les activités de chasse de la région pendant presque toute la période de l'Holocène. À l'aide de relevés aériens, il a été possible d'identifier 72 plaques de glace de tailles différentes. Des relevés sur le terrain ont été effectués sur 65 de ces plaques pour récupérer des restes organiques, et 18 d'entre-elles ont révélé une abondance d'espèces biologiques et des restes de grands mammifères rares (y compris le caribou), des petits mammifères et des oiseaux momifiés, et des artéfacts datant jusqu'à 8000 ans. Les excréments d'animaux permettent d'analyser des macrofossiles de pollen et de plantes afin de faire une reconstruction paléoécologique, ainsi que d'obtenir des renseignements sur le régime alimentaire, la génétique et les parasites. À l'aide de la géochronologie, l'échantillonnage des excréments d'animaux contrôlé par stratigraphie a permis de dater la formation des excréments à aussi loin que 8300 à 8000 ans B.P. La formation des plaques de glace a été presque continue, à l'exception d'une période entre 6700 et 4700 ans B.P. et d'une autre entre 1440 et 1030, lorsque des conditions chaudes ou sèches ou les deux n'ont pas permis à la glace de s'accumuler. La reprise de l'accumulation de glace au cours des 500 dernières années a vraisemblablement provoqué le petit âge glaciaire. La taille des plaques de glace au cours de cette période est facilement calculable grâce aux zones sans lichen qui encerclent chaque plaque. Des études plus récentes de photos aériennes prises entre 1946 et 2001 ont permis de constater une réduction marquée de la taille des plaques de glace. Les données des températures quotidiennes de Whitehorse (de 1942 à 2001) ont été utilisées pour calculer la valeur du degré-jour de fonte qui est en grande partie responsable de la variation de la taille des plaques de glace. Ces données indiquent que même si le plus gros de la fonte s'est produit depuis la fin du petit âge glaciaire, les plaques de glace réagissent beaucoup aux changements de température décennaux

Ethnographic and Archaeological Investigations of Alpine Ice Patches in Southwest Yukon, Canada

Since the original 1997 discovery of ancient hunting implements in melting alpine ice patches of southern Yukon, approximately 146 well-preserved, organic artifacts have been recovered. Most of the artifacts, variously made of antler, bone, wood, and stone, represent complete or partial examples of throwing-dart (atlatl) and bow-and-arrow technology. Radiocarbon dates obtained thus far range from 8360 BP to 90 BP (uncalibrated). Our research indicates that in southern Yukon, throwing-dart technology persisted from at least 8360 BP to approximately 1250 BP, when it was abruptly replaced by bow-and-arrow technology. The collection has afforded archaeologists and First Nation researchers a unique opportunity to learn about past hunting technologies and practices and thus greatly improve our understanding of the enduring relationships between humans and caribou.Depuis la découverte en 1997 d'anciens objets de chasse dans les plaques de glace alpines du sud du Yukon, environ 146 artéfacts organiques bien conservés ont été récupérés. La plupart des artéfacts, faits de bois d'animal, d'os, de bois ou de pierre, représentent des exemples complets ou partiels de propulseur lance-javelins (atlatl) et d'une technologie axée sur l'utilisation d'arc et de flèches. La datation au radiocarbone varie de 8360 ans B.P. à 90 ans B.P. (non étalonné). Les recherches effectuées rélèvent que dans le sud-est du Yukon, la technologie reposant sur l'utilisation du lance-javelines a été en usage de 8360 ans B.P. au moins jusqu'à environ 1250 ans B.P., époque à laquelle elle fut soudain remplacé par la technologie reposant sur l'utilisation de l'ensemble arc et flèche. Grâce à cette collection, les archéologues et les chercheurs des premières nations ont pu en apprendre davantage sur les technologies et les méthodes de chasse utilisées à cette époque et ainsi améliorer leur compréhension des relations durables entre l'humain et le caribou

The Acute Effects of the COVID-19 Pandemic on Physical Activity and Sedentary Behavior in University Students and Employees

International Journal of Exercise Science 13(5): 1326-1339, 2020. The COVID-19 pandemic has closed non-essential businesses which may alter individuals’ leisure behaviors. Consequently, physical activity and sedentary behavior may be negatively impacted as many fitness and recreational centers have been closed. This study aimed to examine the impact of the pandemic on physical activity and sedentary behavior in a sample of university students and employees before and after the university cancelled face-to-face classes and closed campus. Participants (N = 398) completed the validated Godin physical activity questionnaire and the International Physical Activity Questionnaire which assessed physical activity and sedentary behavior pre- and post-cancellation of face-to-face classes. Participants were also separated in the groups (low, moderate, high physical activity) based upon a tertile split of pre-pandemic total physical activity. Physical activity group by time ANOVAs were used to assess potential changes in total physical activity and sedentary behavior. Post-cancellation sedentary behavior was greater (F (1, 388) = 9.2, p = 0.003, partial η2 = 0.032) than pre-cancellation. Physical activity group moderated (F (2, 395) = 22.0, p \u3c 0.001, partial η2 ≥ 0.10) changes in total physical activity from pre- to post cancellation. The high activity group decreased physical activity whereas the moderate and low activity groups increased physical activity (t ≥ 2.4, p ≤ 0.02, Cohen’s d = 0.23). While the university closure increased sedentary behavior across the sample, it only decreased physical activity in participants who were the most active pre-cancellation. Pandemic-related closure of facilities designed for physical activity may disproportionately impact active individuals

In Pursuit of Prehistoric Caribou on Thandlät, Southern Yukon

In 1997, the first author noted a large concentration of caribou (Rangifer sp.) fecal pellets and a caribou antler on a permanent snow patch in the Kusawa Lake area of southern Yukon. Caribou are completely absent from this area today. Coring of the snow patch revealed continuous deposits of fecal pellets to depths of at least 160 cm. The proximal portion of a wooden dart or arrow shaft fragment recovered on the edge of the snow patch represents one of the few organic examples of mid-Holocene hunting technology ever found in Canada. An age of 2450 BP ± 50 years was obtained for the fecal material from approximately 1.6 m below the surface of the snow patch, and the dart was dated at 4360 BP ± 50 years. These dates indicate that aboriginal Yukon hunters have been harvesting caribou at this location for at least 4000 years. The Thandlät site offers a rare opportunity to explore a number of questions regarding the prehistoric ecology of large caribou populations, the implications of climate change for caribou populations, and human use of high-elevation hunting sites.En 1997, le premier auteur a découvert une concentration élevée de boulettes fécales (Rangifer sp.) et des bois de caribou sur une congère dans la région du lac Kusawa, dans le sud du Yukon. Il n'y a plus de caribous dans cette région. Le carottage de la congère a révélé des dépôts de boulettes jusqu'à une profondeur de 160 cm. Un fragment de dard ou de la flèche en bois trouvé sur le bord de la congère représente une des rares découvertes au Canada relatives à ce type d'arme. Il a été déterminé que les matières fécales prélevées dans la congère, à environ 1,6 m de profondeur, sont âgées de 2450 BP ± 50 ans, et que le dard aurait 4360 BP ± 50 ans. Ces dates montrent que les Autochtones du Yukon chassaient déjà le caribou à cet endroit il y a 4000 ans. Le site Thandlät est un des rares endroits où l'on peut observer divers aspects préhistoriques des grandes populations de caribou, des effets des changements climatiques sur les populations de caribous et des activités de chasse à grande altitude

Increased Physical Activity and Reduced Pain with Spinal Cord Stimulation: a 12-Month Study

International Journal of Exercise Science 13(3): 1583-1594, 2020. The purpose of this study was to assess changes in pain and physical activity after replacing a traditional spinal cord stimulation (SCS) implantable pulse generator with a next generation SCS in patients for whom traditional SCS was no longer providing adequate relief of low back and/or leg pain. Subjects (n = 19) who reported that they were no longer receiving adequate relief from traditional SCS were implanted with a next generation SCS. Eighteen additional patients who were receiving relief from traditional SCS were also followed as a control. Both groups (next generation, traditional) were assessed for low-back and limb pain (visual analog scale) and daily physical activity (wearable accelerometer) at baseline and three, six, nine and 12 months following the SCS implant. Relative to baseline, next generation SCS subjects exhibited reductions (p ≤ 0.05 for all) in low-back pain (average reduction of 22%) at every time point, in leg pain (average reduction of 23%) at every time point except six months and increased physical activity (average increase of 57%) at three, six and nine months. As expected, there were no changes in pain or physical activity in the traditional SCS subjects (p ≥ 0.1). In conclusion, pain decreased, and physical activity increased in patients receiving a next generation SCS. Physical activity may serve as an objectively measured marker of pain

Investigating the potential clinical benefit of Selumetinib in resensitising advanced iodine refractory differentiated thyroid cancer to radioiodine therapy (SEL-I-METRY): protocol for a multicentre UK single arm phase II trial

Background Thyroid cancer is the most common endocrine malignancy. Some advanced disease is, or becomes, resistant to radioactive iodine therapy (refractory disease); this holds poor prognosis of 10% 10-year overall survival. Whilst Sorafenib and Lenvatinib are now licenced for the treatment of progressive iodine refractory thyroid cancer, these treatments require continuing treatment and can be associated with significant toxicity. Evidence from a pilot study has demonstrated feasibility of Selumetinib to allow the reintroduction of I-131 therapy; this larger, multicentre study is required to demonstrate the broader clinical impact of this approach before progression to a confirmatory trial. Methods SEL-I-METRY is a UK, single-arm, multi-centre, two-stage phase II trial. Participants with locally advanced or metastatic differentiated thyroid cancer with at least one measureable lesion and iodine refractory disease will be recruited from 8 NHS Hospitals and treated with 4-weeks of oral Selumetinib and assessed for sufficient I-123 uptake (defined as any uptake in a lesion with no previous uptake or 30% or greater increase in uptake). Those with sufficient uptake will be treated with I-131 and followed for clinical outcomes. Radiation absorbed doses will be predicted from I-123 SPECT/CT and verified from scans following the therapy. 60 patients will be recruited to assess the primary objective of whether the treatment schedule leads to increased progression-free survival compared to historical control data. Discussion The SEL-I-METRY trial will investigate the effect of Selumetinib followed by I-131 therapy on progression-free survival in radioiodine refractory patients with differentiated thyroid cancer showing increased radioiodine uptake following initial treatment with Selumetinib. In addition, information on toxicity and dosimetry will be collected. This study presents an unprecedented opportunity to investigate the role of lesional dosimetry in molecular radiotherapy, leading to greater personalisation of therapy. To date this has been a neglected area of research. The findings of this trial will be useful to healthcare professionals and patients alike to determine whether further study of this agent is warranted. It is hoped that the development of the infrastructure to deliver a multicentre trial involving molecular radiotherapy dosimetry will lead to further trials in this field. Trial registration SEL-I-METRY is registered under ISRCTN17468602, 02/12/2015

Multidisciplinary Investigations of Alpine Ice Patches in Southwest Yukon, Canada: Paleoenvironmental and Paleobiological Investigations

Since the discovery of dung-rich alpine ice patches in southwest Yukon in 1997, continuing multidisciplinary studies have provided a unique window on the biology, climate, and hunting activity in this region over much of the Holocene. Aerial surveys have identified 72 ice patches of variable size, and 65 patches have been ground-surveyed for organic remains. Of these, 35 yielded an abundance of biological specimens, including caribou and other rare large mammal remains, mummified small mammals and birds, and artifacts spanning 8000 years. The dung provides pollen and plant macrofossils for analysis and paleoenvironmental reconstruction, as well as dietary, genetic, and parasitic information. Stratigraphically controlled sampling of dung within ice layers has yielded a geochronology placing their formation as early as 8300 to 8000 years BP. Ice patch formation was nearly continuous except for an interval between 6700 and 4700 years BP and another between 1440 and 1030, when warm or dry conditions (or both) resulted in no net ice accumulation. Resumption of ice accumulation over the following 500 years likely culminated in the Little Ice Age. The size of the ice patches during this period is made evident by a lichen-free zone that haloes each patch. More recently, interpretation of air photos from 1946 to 2001 has found a significant reduction in ice patch dimensions. Daily temperature records for Whitehorse (1942-2001) were used to calculate melting degree-day values that account for a large part of the variation in ice patch size, indicating that while considerable melting has likely occurred since the end of the Little Ice Age, the ice patches are highly sensitive to decadal changes in temperature.Depuis la découverte de plaques de glace alpines riches en excréments d'animaux dans le sud-ouest du Yukon en 1997, des études multidisciplinaires continues offrent une fenêtre unique sur la biologie, le climat et les activités de chasse de la région pendant presque toute la période de l'Holocène. À l'aide de relevés aériens, il a été possible d'identifier 72 plaques de glace de tailles différentes. Des relevés sur le terrain ont été effectués sur 65 de ces plaques pour récupérer des restes organiques, et 18 d'entre-elles ont révélé une abondance d'espèces biologiques et des restes de grands mammifères rares (y compris le caribou), des petits mammifères et des oiseaux momifiés, et des artéfacts datant jusqu'à 8000 ans. Les excréments d'animaux permettent d'analyser des macrofossiles de pollen et de plantes afin de faire une reconstruction paléoécologique, ainsi que d'obtenir des renseignements sur le régime alimentaire, la génétique et les parasites. À l'aide de la géochronologie, l'échantillonnage des excréments d'animaux contrôlé par stratigraphie a permis de dater la formation des excréments à aussi loin que 8300 à 8000 ans B.P. La formation des plaques de glace a été presque continue, à l'exception d'une période entre 6700 et 4700 ans B.P. et d'une autre entre 1440 et 1030, lorsque des conditions chaudes ou sèches ou les deux n'ont pas permis à la glace de s'accumuler. La reprise de l'accumulation de glace au cours des 500 dernières années a vraisemblablement provoqué le petit âge glaciaire. La taille des plaques de glace au cours de cette période est facilement calculable grâce aux zones sans lichen qui encerclent chaque plaque. Des études plus récentes de photos aériennes prises entre 1946 et 2001 ont permis de constater une réduction marquée de la taille des plaques de glace. Les données des températures quotidiennes de Whitehorse (de 1942 à 2001) ont été utilisées pour calculer la valeur du degré-jour de fonte qui est en grande partie responsable de la variation de la taille des plaques de glace. Ces données indiquent que même si le plus gros de la fonte s'est produit depuis la fin du petit âge glaciaire, les plaques de glace réagissent beaucoup aux changements de température décennaux