Aerodynamic Simulation of Runback Ice Accretion

This report presents the results of recent investigations into the aerodynamics of simulated runback ice accretion on airfoils. Aerodynamic tests were performed on a full-scale model using a high-fidelity, ice-casting simulation at near-flight Reynolds (Re) number. The ice-casting simulation was attached to the leading edge of a 72-in. (1828.8-mm ) chord NACA 23012 airfoil model. Aerodynamic performance tests were conducted at the ONERA F1 pressurized wind tunnel over a Reynolds number range of 4.7?10(exp 6) to 16.0?10(exp 6) and a Mach (M) number ran ge of 0.10 to 0.28. For Re = 16.0?10(exp 6) and M = 0.20, the simulated runback ice accretion on the airfoil decreased the maximum lift coe fficient from 1.82 to 1.51 and decreased the stalling angle of attack from 18.1deg to 15.0deg. The pitching-moment slope was also increased and the drag coefficient was increased by more than a factor of two. In general, the performance effects were insensitive to Reynolds numb er and Mach number changes over the range tested. Follow-on, subscale aerodynamic tests were conducted on a quarter-scale NACA 23012 model (18-in. (457.2-mm) chord) at Re = 1.8?10(exp 6) and M = 0.18, using low-fidelity, geometrically scaled simulations of the full-scale castin g. It was found that simple, two-dimensional simulations of the upper- and lower-surface runback ridges provided the best representation of the full-scale, high Reynolds number iced-airfoil aerodynamics, whereas higher-fidelity simulations resulted in larger performance degrada tions. The experimental results were used to define a new subclassification of spanwise ridge ice that distinguishes between short and tall ridges. This subclassification is based upon the flow field and resulting aerodynamic characteristics, regardless of the physical size of the ridge and the ice-accretion mechanism

Aerodynamic Simulation of Ice Accretion on Airfoils

This report describes recent improvements in aerodynamic scaling and simulation of ice accretion on airfoils. Ice accretions were classified into four types on the basis of aerodynamic effects: roughness, horn, streamwise, and spanwise ridge. The NASA Icing Research Tunnel (IRT) was used to generate ice accretions within these four types using both subscale and full-scale models. Large-scale, pressurized windtunnel testing was performed using a 72-in.- (1.83-m-) chord, NACA 23012 airfoil model with high-fidelity, three-dimensional castings of the IRT ice accretions. Performance data were recorded over Reynolds numbers from 4.5 x 10(exp 6) to 15.9 x 10(exp 6) and Mach numbers from 0.10 to 0.28. Lower fidelity ice-accretion simulation methods were developed and tested on an 18-in.- (0.46-m-) chord NACA 23012 airfoil model in a small-scale wind tunnel at a lower Reynolds number. The aerodynamic accuracy of the lower fidelity, subscale ice simulations was validated against the full-scale results for a factor of 4 reduction in model scale and a factor of 8 reduction in Reynolds number. This research has defined the level of geometric fidelity required for artificial ice shapes to yield aerodynamic performance results to within a known level of uncertainty and has culminated in a proposed methodology for subscale iced-airfoil aerodynamic simulation

A cross-scale analysis to understand and quantify the effects of photosynthetic enhancement on crop growth and yield across environments

Abstract Photosynthetic manipulation provides new opportunities for enhancing crop yield. However, understanding and quantifying the importance of individual and multiple manipulations on the seasonal biomass growth and yield performance of target crops across variable production environments is limited. Using a state-of-the-art cross-scale model in the APSIM platform we predicted the impact of altering photosynthesis on the enzyme-limited (Ac) and electron transport-limited (Aj) rates, seasonal dynamics in canopy photosynthesis, biomass growth, and yield formation via large multiyear-by-location crop growth simulations. A broad list of promising strategies to improve photosynthesis for C3 wheat and C4 sorghum were simulated. In the top decile of seasonal outcomes, yield gains were predicted to be modest, ranging between 0% and 8%, depending on the manipulation and crop type. We report how photosynthetic enhancement can affect the timing and severity of water and nitrogen stress on the growing crop, resulting in nonintuitive seasonal crop dynamics and yield outcomes. We predicted that strategies enhancing Ac alone generate more consistent but smaller yield gains across all water and nitrogen environments, Aj enhancement alone generates larger gains but is undesirable in more marginal environments. Large increases in both Ac and Aj generate the highest gains across all environments. Yield outcomes of the tested manipulation strategies were predicted and compared for realistic Australian wheat and sorghum production. This study uniquely unpacks complex cross-scale interactions between photosynthesis and seasonal crop dynamics and improves understanding and quantification of the potential impact of photosynthesis traits (or lack of it) for crop improvement research

Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

Experimental study of full-scale iced-airfoil aerodynamic performance using sub-scale simulations

Determining the aerodynamic effects of ice accretion on aircraft surfaces is an important step in aircraft design and certification. The goal of this work was to develop a complete sub-scale wind tunnel simulation methodology based on knowledge of the detailed iced-airfoil flowfield that allows the accurate measurement of aerodynamic penalties associated with the accretion of ice on an airfoil and to validate this methodology using full-scale iced-airfoil performance data obtained at near-flight Reynolds numbers. In earlier work, several classifications of ice shape were developed based on key aerodynamic features in the iced-airfoil flowfield: ice roughness, streamwise ice, horn ice, and tall and short spanwise-ridge ice. Castings of each of these classifications were acquired on a full-scale NACA 23012 airfoil model and the aero- dynamic performance of each was measured at a Reynolds number of 12.0 x 10^6 and a Mach number = 0.20. In the current study, sub-scale simple-geometry and 2-D smooth simulations of each of these castings were constructed based on knowledge of iced-airfoil flowfields. The effects of each simulation on the aerodynamic performance of an 18-inch chord NACA 23012 airfoil model was measured in the University of Illinois 3 x 4 ft. wind tunnel at a Reynolds number of 1.8 x 10^6 and a Mach number of 0.18 and compared with that measured for the corresponding full-scale casting at high Reynolds number. Geometrically-scaled simulations of the horn-ice and tall spanwise-ridge ice castings modeled Cl,max to within 2% and Cd,min to within 15%. Good qualitative agreement in the Cp distributions suggests that important geometric features such as horn and ridge height, surface location, and angle with respect to the airfoil chordline were appropriately modeled. Geometrically-scaled simulations of the ice roughness, streamwise ice, and short-ridge ice tended to have conservative Cl,max and Cd. The aerodynamic performance of simulations of these types of accretion was found to be sensitive to roughness height and concentration. Scaled roughness heights smaller than those found on the casting were necessary to improve simulation accuracy, resulting in Cl,max and Cd,min within 3% and 5% of the casting, respectively

Experimental Study of Full-Scale Iced -Airfoil Aerodynamic Performance Using Sub-Scale Simulations

254 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2009.Determining the aerodynamic effects of ice accretion on aircraft surfaces is an important step in aircraft design and certification. The goal of this work was to develop a complete sub-scale wind tunnel simulation methodology based on knowledge of the detailed iced-airfoil flowfield that allows the accurate measurement of aerodynamic penalties associated with the accretion of ice on an airfoil and to validate this methodology using full-scale iced-airfoil performance data obtained at near-flight Reynolds numbers. In earlier work, several classifications of ice shape were developed based on key aerodynamic features in the iced-airfoil flowfield: ice roughness, streamwise ice, horn ice, and tall and short spanwise-ridge ice. Castings of each of these classifications were acquired on a full-scale NACA 23012 airfoil model and the aero-dynamic performance of each was measured at a Reynolds number of 12.0 x 106 and a Mach number = 0.20. In the current study, sub-scale simple-geometry and 2-D smooth simulations of each of these castings were constructed based on knowledge of iced-airfoil flowfields. The effects of each simulation on the aerodynamic performance of an 18-inch chord NACA 23012 airfoil model was measured in the University of Illinois 3 x 4 ft. wind tunnel at a Reynolds number of 1.8 x 106 and a Mach number of 0.18 and compared with that measured for the corresponding full-scale casting at high Reynolds number. Geometrically-scaled simulations of the horn-ice and tall spanwise-ridge ice castings modeled C l,maxto within 2% and Cd,min to within 15%. Good qualitative agreement in the Cp distributions suggests that important geometric features such as horn and ridge height, surface location, and angle with respect to the airfoil chordline were appropriately modeled. Geometrically-scaled simulations of the ice roughness, streamwise ice, and short-ridge ice tended to have conservative C l,max and Cd. The aerodynamic performance of simulations of these types of accretion was found to be sensitive to roughness height and concentration. Scaled roughness heights smaller than those found on the casting were necessary to improve simulation accuracy, resulting in Cl,max and Cd,min within 3% and 5% of the casting, respectively.U of I OnlyRestricted to the U of I community idenfinitely during batch ingest of legacy ETD

Baseline Assessment of 25-Hydroxyvitamin D Reference Material and Proficiency Testing/External Quality Assurance Material Commutability: A Vitamin D Standardization Program Study.

The Vitamin D Standardization Program (VDSP) coordinated a study in 2012 to assess the commutability of reference materials and proficiency testing/external quality assurance materials for total 25-hydroxyvitamin D [25(OH)D] in human serum, the primary indicator of vitamin D status. A set of 50 single-donor serum samples as well as 17 reference and proficiency testing/external quality assessment materials were analyzed by participating laboratories that used either immunoassay or LC-MS methods for total 25(OH)D. The commutability test materials included National Institute of Standards and Technology Standard Reference Material 972a Vitamin D Metabolites in Human Serum as well as materials from the College of American Pathologists and the Vitamin D External Quality Assessment Scheme. Study protocols and data analysis procedures were in accordance with Clinical and Laboratory Standards Institute guidelines. The majority of the test materials were found to be commutable with the methods used in this commutability study. These results provide guidance for laboratories needing to choose appropriate reference materials and select proficiency or external quality assessment programs and will serve as a foundation for additional VDSP studies