723 research outputs found
Differences in plasma and peritoneal fluid proteomes identifies potential biomarkers associated with survival following strangulating small intestinal disease
Duality Twists, Orbifolds, and Fluxes
We investigate compactifications with duality twists and their relation to
orbifolds and compactifications with fluxes. Inequivalent compactifications are
classified by conjugacy classes of the U-duality group and result in gauged
supergravities in lower dimensions with nontrivial Scherk-Schwarz potentials on
the moduli space. For certain twists, this mechanism is equivalent to
introducing internal fluxes but is more general and can be used to stabilize
some of the moduli. We show that the potential has stable minima with zero
energy precisely at the fixed points of the twist group. In string theory, when
the twist belongs to the T-duality group, the theory at the minimum has an
exact CFT description as an orbifold. We also discuss more general twists by
nonperturbative U-duality transformations.Comment: 30 pages, harvmac, references and brief comments on gauged
supergravity adde
EYM equations in the presence of q-stars
We study Einstein-Yang-Mills equations in the presence of gravitating
non-topological soliton field configurations, of q-ball type. We produce
numerical solutions, stable with respect to gravitational collapse and to
fission into free particles, and we study the effect of the field strength and
the eigen-frequency to the soliton parameters. We also investigate the
formation of such soliton stars when the spacetime is asymptotically anti de
Sitter.Comment: 11 pages, to appear in Phys. Rev.
Gauging and symplectic blowing up in nonlinear sigma-models: I. point singularities
In this paper a two dimensional non-linear sigma model with a general
symplectic manifold with isometry as target space is used to study symplectic
blowing up of a point singularity on the zero level set of the moment map
associated with a quasi-free Hamiltonian action. We discuss in general the
relation between symplectic reduction and gauging of the symplectic isometries
of the sigma model action. In the case of singular reduction, gauging has the
same effect as blowing up the singular point by a small amount. Using the
exponential mapping of the underlying metric, we are able to construct
symplectic diffeomorphisms needed to glue the blow-up to the global reduced
space which is regular, thus providing a transition from one symplectic sigma
model to another one free of singularities.Comment: 32 pages, LaTex, THEP 93/24 (corrected and expanded(about 5 pages)
version
Comprehensive analysis of The Cancer Genome Atlas reveals a unique gene and non-coding RNA signature of fibrolamellar carcinoma
Fibrolamellar carcinoma (FLC) is a unique liver cancer primarily affecting young adults and characterized by a fusion event between DNAJB1 and PRKACA. By analyzing RNA-sequencing data from The Cancer Genome Atlas (TCGA) for >9,100 tumors across ~30 cancer types, we show that the DNAJB1-PRKACA fusion is specific to FLCs. We demonstrate that FLC tumors (n = 6) exhibit distinct messenger RNA (mRNA) and long intergenic non-coding RNA (lincRNA) profiles compared to hepatocellular carcinoma (n = 263) and cholangiocarcinoma (n = 36), the two most common liver cancers. We also identify a set of mRNAs (n = 16) and lincRNAs (n = 4), including LINC00473, that distinguish FLC from ~25 other liver and non-liver cancer types. We confirm this unique FLC signature by analysis of two independent FLC cohorts (n = 20 and 34). Lastly, we validate the overexpression of one specific gene in the FLC signature, carbonic anhydrase XII (CA12), at the protein level by western blot and immunohistochemistry. Both the mRNA and lincRNA signatures support a major role for protein kinase A (PKA) signaling in shaping the FLC gene expression landscape, and present novel candidate FLC oncogenes that merit further investigation
Supersymmetric solutions of PT-/non-PT-symmetric and non-Hermitian Screened Coulomb potential via Hamiltonian hierarchy inspired variational method
The supersymmetric solutions of PT-symmetric and Hermitian/non-Hermitian
forms of quantum systems are obtained by solving the Schrodinger equation for
the Exponential-Cosine Screened Coulomb potential. The Hamiltonian hierarchy
inspired variational method is used to obtain the approximate energy
eigenvalues and corresponding wave functions.Comment: 13 page
C^2/Z_n Fractional branes and Monodromy
We construct geometric representatives for the C^2/Z_n fractional branes in
terms of branes wrapping certain exceptional cycles of the resolution. In the
process we use large radius and conifold-type monodromies, and also check some
of the orbifold quantum symmetries. We find the explicit Seiberg-duality which
connects our fractional branes to the ones given by the McKay correspondence.
We also comment on the Harvey-Moore BPS algebras.Comment: 34 pages, v1 identical to v2, v3: typos fixed, discussion of
Harvey-Moore BPS algebras update
Hierarchical Spherical Model from a Geometric Point of View
A continuous version of the hierarchical spherical model at dimension d=4 is
investigated. Two limit distribution of the block spin variable X^{\gamma},
normalized with exponents \gamma =d+2 and \gamma =d at and above the critical
temperature, are established. These results are proven by solving certain
evolution equations corresponding to the renormalization group (RG)
transformation of the O(N) hierarchical spin model of block size L^{d} in the
limit L to 1 and N to \infty . Starting far away from the stationary Gaussian
fixed point the trajectories of these dynamical system pass through two
different regimes with distinguishable crossover behavior. An interpretation of
this trajectories is given by the geometric theory of functions which describe
precisely the motion of the Lee--Yang zeroes. The large-- limit of RG
transformation with L^{d} fixed equal to 2, at the criticality, has recently
been investigated in both weak and strong (coupling) regimes by Watanabe
\cite{W}. Although our analysis deals only with N=\infty case, it complements
various aspects of that work.Comment: 27 pages, 6 figures, submitted to Journ. Stat. Phy
The scientific potential of space-based gravitational wave detectors
The millihertz gravitational wave band can only be accessed with a
space-based interferometer, but it is one of the richest in potential sources.
Observations in this band have amazing scientific potential. The mergers
between massive black holes with mass in the range 10 thousand to 10 million
solar masses, which are expected to occur following the mergers of their host
galaxies, produce strong millihertz gravitational radiation. Observations of
these systems will trace the hierarchical assembly of structure in the Universe
in a mass range that is very difficult to probe electromagnetically. Stellar
mass compact objects falling into such black holes in the centres of galaxies
generate detectable gravitational radiation for several years prior to the
final plunge and merger with the central black hole. Measurements of these
systems offer an unprecedented opportunity to probe the predictions of general
relativity in the strong-field and dynamical regime. Millihertz gravitational
waves are also generated by millions of ultra-compact binaries in the Milky
Way, providing a new way to probe galactic stellar populations. ESA has
recognised this great scientific potential by selecting The Gravitational
Universe as its theme for the L3 large satellite mission, scheduled for launch
in ~2034. In this article we will review the likely sources for millihertz
gravitational wave detectors and describe the wide applications that
observations of these sources could have for astrophysics, cosmology and
fundamental physics.Comment: 18 pages, 2 figures, contribution to Gravitational Wave Astrophysics,
the proceedings of the 2014 Sant Cugat Forum on Astrophysics; v2 includes one
additional referenc
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