Developing Urban Deer Management Plans: The Need for Public Education

Independent public opinion surveys concerning urban deer (Odocoileus virginianus) management were conducted in two Virginia communities. A total of 346 citizens were interviewed in two Random Digit Dial telephone surveys. In addition to questions concerning management techniques and their administration, participants were asked about their experience with deer, their awareness of problems with deer in the area, and their enjoyment of deer. In both localities, non-lethal controls were preferred over lethal controls; trapping and relocation, fencing, repellents, and birth control measures were favored by a majority of residents. The only lethal control acceptable to residents in both communities was the use of controlled hunts. There was no consensus about who should administer deer management or who should be fiscally responsible. Those aware of deer problems are less likely to report enjoying having deer in the area. Preferences for non-lethal controls and lack of consensus on responsibility for deer management demonstrate the need for public education concerning the costs, consequences, and accountability for deer control. Survey results regarding citizens’ preferences for various management practices demonstrate the challenges wildlife professionals face in assisting communities in developing deer management plans. Wildlife professionals saddled with managing human-wildlife conflicts need to recognize that part of their role is educating the public about the ecology of the animal(s), management techniques, and their implications. As experience with deer problem increases, citizens are likely to enjoy deer less and become increasingly interested in deer management

The organizational social context of mental health services and clinician attitudes toward evidence-based practice: a United States national study.

UnlabelledABSTBACKGROUND: Evidence-based practices have not been routinely adopted in community mental health organizations despite the support of scientific evidence and in some cases even legislative or regulatory action. We examined the association of clinician attitudes toward evidence-based practice with organizational culture, climate, and other characteristics in a nationally representative sample of mental health organizations in the United States.MethodsIn-person, group-administered surveys were conducted with a sample of 1,112 mental health service providers in a nationwide sample of 100 mental health service institutions in 26 states in the United States. The study examines these associations with a two-level Hierarchical Linear Modeling (HLM) analysis of responses to the Evidence-Based Practice Attitude Scale (EBPAS) at the individual clinician level as a function of the Organizational Social Context (OSC) measure at the organizational level, controlling for other organization and clinician characteristics.ResultsWe found that more proficient organizational cultures and more engaged and less stressful organizational climates were associated with positive clinician attitudes toward adopting evidence-based practice.ConclusionsThe findings suggest that organizational intervention strategies for improving the organizational social context of mental health services may contribute to the success of evidence-based practice dissemination and implementation efforts by influencing clinician attitudes

Results of a phase I-II study of fenretinide and rituximab for patients with indolent B-cell lymphoma and mantle cell lymphoma.

Fenretinide, a synthetic retinoid, induces apoptotic cell death in B-cell non-Hodgkin lymphoma (B-NHL) and acts synergistically with rituximab in preclinical models. We report results from a phase I-II study of fenretinide with rituximab for B-NHLs. Eligible diagnoses included indolent B-NHL or mantle cell lymphoma. The phase I design de-escalated from fenretinide at 900 mg/

Identification and assessment of potential wind energy project sites in the State of Maryland

Gemstone Team RenewablesThe international scientific community has reached consensus that greenhouse gas emissions must be reduced to minimize global climate change impacts on the environment, economy, and public health. In 2007, the University of Maryland's Climate Action Plan Workgroup was tasked with charting the University’s path toward carbon neutrality. To aid in this effort, this report identifies the best sites in Western Maryland for wind development. Geographic information systems data on wind speed, land protections, and transmission infrastructure were used to assign scores for physical, social and environmental characteristics of prospective sites. Attribute scores were entered into a systematic weighting system to determine overall site suitability. A financial analysis was conducted for the highest ranked sites using RETScreen software, which generated projections for payback periods and return on investment. The list of suitable sites produced through this research provides the University with a starting point for exploration of off-site wind power production

Super‐Resolution Microscopy Reveals Shape and Distribution of Dislocations in Single‐Crystal Nanocomposites

With their potential to offer new properties, single crystals containing nanoparticles provide an attractive class of nanocomposite materials. However, to fully profit from these, it is essential that we can characterise their 3D structures, identifying the locations of individual nanoparticles, and the defects present within the host crystals. Using calcite crystals containing quantum dots as a model system, we here use 3D stochastic optical reconstruction microscopy (STORM) to locate the positions of the nanoparticles within the host crystal. The nanoparticles are shown to preferentially associate with dislocations in a manner previously recognised for atomic impurities, rendering these defects visible by STORM. Our images also demonstrate that the types of dislocations formed at the crystal/substrate interface vary according to the nucleation face, and dislocation loops are observed that have entirely different geometries to classic misfit dislocations. This approach offers a rapid, easily accessed, and non‐destructive method for visualising the dislocations present within crystals, and gives insight into the mechanisms by which additives become occluded within crystals

Altered ceramide metabolism is a feature in the extracellular vesicle-mediated spread of alpha-synuclein in Lewy body disorders

This study was funded by the Lewy Body Society and the Michael J. Fox Foundation for Parkinson’s Research. A.H. and B.M.B. gratefully acknowledge funding from the Knut och Alice Wallenberg Stiftelse through the Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Sweden. S.T., M.K.D. and P.D.W. gratefully acknowledge the financial support of the European Regional Development Fund, Scottish Funding Council and Highlands and Islands Enterprise. Newcastle University TEM Services acknowledge BBSRC support (Grant code BB/R013942/1). The Research was supported by the National Institute for Health Research Newcastle Biomedical Research Centre based at Newcastle Hospitals NHS Foundation Trust and Newcastle University. The Newcastle Brain Tissue Resource is supported by grants from the UK Medical Research Council and the Brains for Dementia Research, a joint venture between Alzheimer’s Society and Alzheimer’s Research UK.Mutations in glucocerebrosidase (GBA) are the most prevalent genetic risk factor for Lewy body disorders (LBD)—collectively Parkinson’s disease, Parkinson’s disease dementia and dementia with Lewy bodies. Despite this genetic association, it remains unclear how GBA mutations increase susceptibility to develop LBD. We investigated relationships between LBD-specific glucocerebrosidase deficits, GBA-related pathways, and α-synuclein levels in brain tissue from LBD and controls, with and without GBA mutations. We show that LBD is characterised by altered sphingolipid metabolism with prominent elevation of ceramide species, regardless of GBA mutations. Since extracellular vesicles (EV) could be involved in LBD pathogenesis by spreading disease-linked lipids and proteins, we investigated EV derived from post-mortem cerebrospinal fluid (CSF) and brain tissue from GBA mutation carriers and non-carriers. EV purified from LBD CSF and frontal cortex were heavily loaded with ceramides and neurodegeneration-linked proteins including alpha-synuclein and tau. Our in vitro studies demonstrate that LBD EV constitute a “pathological package” capable of inducing aggregation of wild-type alpha-synuclein, mediated through a combination of alpha-synuclein–ceramide interaction and the presence of pathological forms of alpha-synuclein. Together, our findings indicate that abnormalities in ceramide metabolism are a feature of LBD, constituting a promising source of biomarkers, and that GBA mutations likely accelerate the pathological process occurring in sporadic LBD through endolysosomal deficiency.Publisher PDFPeer reviewe

Optical Propagation and Communication

Contains an introduction and reports on five research projects.Maryland Procurement Office Contract MDA 904-90-C-5070National Science Foundation Grant ECS 87-18970National Institute of Standards and Technology Grant 60-NANBOD-1052U.S. Army Research Office Grant DAAL03-90-G-0128U.S. Army Research Office Contract DAAL03-87-K-0117U.S. Navy - Office of Naval Research Grant N00014-89-J-1163U.S. Air Force - Office of Scientific Research Contract F49620-90-C-003

UK research priority setting for childhood neurological conditions

Aim: To identify research priorities regarding the effectiveness of interventions for children and young people (CYP) with childhood neurological conditions (CNCs). These include common conditions such as epilepsies and cerebral palsy, as well as many rare conditions. Method: The National Institute for Health and Care Research (NIHR) and the James Lind Alliance (JLA) champion and facilitate priority setting partnerships (PSPs) between patients, caregivers, and clinicians (stakeholders) to identify the most important unanswered questions for research (uncertainties). A NIHR–JLA and British Paediatric Neurology Association collaboration used the JLA PSP methodology. This consisted of two surveys to stakeholders: survey 1 (to identify uncertainties) and survey 2 (a prioritization survey). The final top 10 priorities were agreed by consensus in a stakeholder workshop. Results: One hundred and thirty‐two charities and partner organizations were invited to participate. In survey 1, 701 participants (70% non‐clinicians, including CYP and parent and caregivers) submitted 1800 uncertainties from which 44 uncertainties were identified for prioritization in survey 2; from these, 1451 participants (83% non‐clinicians) selected their top 10 priorities. An unweighted amalgamated score across participant roles was used to select 26. In the final workshop, 14 health care professionals, 11 parent and caregivers, and two CYP ranked the 26 questions to finalize the top 10 priorities. Ten top priority questions were identified regarding interventions to treat CYP with CNCs and their associated comorbidities, for example, sleep, emotional well‐being, and distressing symptoms. Interpretation: The results of this study will inform research into the effectiveness of interventions for children with neurological conditions

Flux Rope Modeling of the 2022 September 5 Coronal Mass Ejection Observed by Parker Solar Probe and Solar Orbiter from 0.07 to 0.69 au

As both Parker Solar Probe (PSP) and Solar Orbiter (SolO) reach heliocentric distances closer to the Sun, they present an exciting opportunity to study the structure of coronal mass ejections (CMEs) in the inner heliosphere. We present an analysis of the global flux rope structure of the 2022 September 5 CME event that impacted PSP at a heliocentric distance of only 0.07 au and SolO at 0.69 au. We compare in situ measurements at PSP and SolO to determine global and local expansion measures, finding a good agreement between magnetic field relationships with heliocentric distance, but significant differences with respect to flux rope size. We use PSP/Wide-Field Imager for Solar Probe images as input to the ELlipse Evolution model based on Heliospheric Imager data (or ELEvoHI), providing a direct link between remote and in situ observations; we find a large discrepancy between the resulting modeled arrival times, suggesting that the underlying model assumptions may not be suitable when using data obtained close to the Sun, where the drag regime is markedly different in comparison to larger heliocentric distances. Finally, we fit the SolO's magnetometer and PSP's FIELDS data independently with the 3D Coronal ROpe Ejection (or 3DCORE) model, and find that many parameters are consistent between spacecraft. However, challenges are apparent when reconstructing a global 3D structure that aligns with arrival times at PSP and SolO, likely due to the large radial and longitudinal separations between spacecraft. From our model results, it is clear the solar wind background speed and drag regime strongly affect the modeled expansion and propagation of CMEs and need to be taken into consideration

Exhumation of the central Wasatch Mountains, Utah: 2. Thermokinematic model of exhumation, erosion, and thermochronometer interpretation

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95279/1/jgrb13381.pd