Computational Analysis of the Influence of Dissolution-Diffusion and Specific Binding on Drug Transport in the Arterial Wall following Stent-based Delivery

A computational model of the transport of drugs eluted from a drug-eluting stent (DES) in the arterial wall is developed to study the influence of considering a non-linear model of dissolution-diffusion in the polymeric strut coating of the stent and a non-linear saturable reversible reaction model in the tissue to describe drug specific and non-specific binding

Del papel a la realidad: efectividad de las políticas y acciones de igualdad de género promovidas por entes gubernamentales en las empresas españolas.

La finalidad del presente trabajo es descubrir, por medio de la investigación, si las políticas y acciones en favor de la igualdad de género desarrolladas por el Estado están siendo efectivas a nivel empresarial. Para esto, se realiza un análisis previo de la Ley actual de Igualdad de Género, estudiaremos cómo se encuentra la sociedad en la actualidad en referencia a esto, analizaremos los Planes de Igualdad de dos empresas y, finalmente, se realizarán entrevistas en profundidad a los empleados de éstas. <br /

Sentinel : analítica sobre percepción de corrupción en Facebook

En este documento describimos cómo aplicando diferentes técnicas de análisis y minería de datos a publicaciones y comentarios extraídos de Facebook, se puede obtener información acerca del estado actual de la percepción de líderes de opinión, partidos políticos, instituciones y casos de corrupción en Colombia. Los resultados obtenidos muestran que los datos generados en redes sociales son un insumo importante para encontrar nuevos indicadores de comportamiento y percepción de los usuarios y, asimismo, permite apoyar iniciativas anticorrupción. El proyecto desarrollado demuestra un gran potencial y se espera que sirva como base para futuras investigaciones y mejoras en la lucha anticorrupción.This document describes how we can obtain information about the current State of corruption, political parties, politics and institutions in Colombia by applying different data mining and other analysis techniques to Facebook posts and comments. The results showed that the data generated in Social Networks are an important resource to find new indicators of behavior and perception of users and, in additíon, they enable new anticorruption initiatives. The project shows great potential and is expected to serve as a foundation for future research and improvements in the fight against corruption.Ingeniero (a) de SistemasPregrad

How does vessel curvature influence drug release from DES and drug transport in arterial tissue?

Several computational models of transport of drugs eluted from drug-eluting stents (DES) in curved arteries were developed in order to investigate the influence of the arterial curvature and complex geometries on drug transport in the blood flow and in the arterial wall

Modelo numérico del proceso de reestenosis tras la implantación de un stent

En este trabajo se presenta un modelo numérico continuo basado en una geometría 2D aximétrica para reproducir el proceso de reestenosis que tiene lugar, probablemente en todos los pacientes, después de la implantación de un stent farmacoactivo (DES) en una arteria coronaria

Enfermedades hepáticas y covid-19: un problema de salud pública a nivel mundial.

The Covid-19 disease caused by the SARS-CoV-2 virus is considered of great importanceas it is a public health problem. It is currently known that Covid-19 is a systemic diseasethat can affect multiple organs and tissues and can be fatal. Liver involvement in relationto Covid-19 resembles any liver damage that occurs during the disease process. Theobjective of this study is to analyze liver diseases and Covid-19: a public health problemworldwide due to the impact present on liver diseases such as: Cirrhosis, HepaticSteatosis, Hepatitis B and C, among others. For the development of the article, adescriptive research and documentary design was used, based on information collectedfrom articles published in the following data such as: Medline, Pubmed, Googleacademic, Elsevier and Scielo. With the Boolean AND, OR, NOT and MESH terms thataddress the liver, Covid-19, prevalence of liver diseases, diagnostic tests and the objectof study was investigated to describe the relationship that exists between these twovariables. Results: it was shown that there are different liver diseases related to Covid-19, with hepatitis C prevailing with 61.40% and Covid-19 with 46.2%, indicating thelaboratory diagnostic tests considered for the detection of liver diseases and Covid-19. Inconclusion, it was shown that there is an association between the different liver diseasesin Covid-19 positive patients.  La enfermedad del Covid-19 ocasionada por el virus SARS-CoV-2, es considerada degran importancia por ser un problema de salud pública. Se conoce actualmente que Covid-19, es una enfermedad sistémica que puede afectar múltiples órganos y tejidos que puedeser fatal. La afectación hepática en relación a la Covid-19 se asemeja a cualquier dañohepático que ocurre durante el proceso de la enfermedad. El presente estudio tiene comoobjetivo, Analizar las enfermedades hepáticas y Covid-19: un problema de salud públicaa nivel mundial por el impacto presente en las enfermedades hepáticas como: Cirrosis,Esteatosis hepática, Hepatitis B y C, entre otros. Para el desarrollo del artículo se utilizóuna investigación de tipo descriptivo y diseño documental, a partir de informaciónrecopilada de artículos publicados en los siguientes datos como: Medline, Pubmed,Google académico, Elsevier y Scielo. Con los booleanos AND, OR, NOT y términosMESH que abordan el hígado, Covid-19, prevalencia de las enfermedades hepáticas,pruebas diagnósticas y se procedió a investigar el objeto de estudio para describir larelación que existe entre estas dos variables. Resultados: se demuestro que existendiferentes enfermedades hepáticas relacionadas al Covid-19, prevaleciendo la hepatitis Ccon 61,40% y el Covid-19 con 46,2%, indicando las pruebas diagnósticas de laboratorioconsideradas para la detección de enfermedades del hígado y Covid-19. En conclusión,se evidenció que existe una asociación entre las diferentes enfermedades hepáticas enpacientes positivos de Covid-19

Empirically-derived food pattern and total ortality in the PREDIMED study

[Background]: There has been growing interest in the last years in assessing the relationship between diet and disease through the study of whole dietary patterris and not only focusing on single nutrients or foods. Though several studies have assessed the relationship between a posteriori dietary patterns and different health outcomes, there is little evidence on post hoc dietary patterns and all cause mortality in Southern European populations.[Objective]: To identify the association between a posteriori defined major dietary patterns and total mortality in the PREDIMED study. Methods We followed-up 7,340 participants (57.5 percent women, mean age: 67 years) during a median follow-up time of 4.8 years. To assess dietary exposures, a validated 137-item semi-quantitative food- frequency questionnaire was administered. Dietary patterns were ascertained through a factor analysis based on 30 predefined food groups. Participants were classified according to tertiles of adherence to dietary pattern scores at baseline. Cox regression models were used to estimate multivariable-adjusted hazard ratios (HR) for mortality. Deaths were confirmed by review of medical records and consultation of the National Death Index.[Results]: We identified two major dietary patterns: the “Western” dietary pattern and “Mediterranean” dietary pattern. During follow- up, 337 participants died. Among deceased participants, the median age of death was 70 (6.5). After controlling for potential confounders including the intervention group, higher baseline adherence to a “Mediterranean” dietary pattern was associated with lower risk of all- cause mortality (adjusted HR for third tertile vs. first textile: 0.68; 95 la CI: 0.49—0.95) (p for trend 0.028). [Conclusion]: Higher adherence to a Mediterranean-type diet may reduce the risk of all-cause mortality in elderly people at high cardiovascular risk

A Nutraceutical Rich in Docosahexaenoic Acid Improves Portal Hypertension in a Preclinical Model of Advanced Chronic Liver Disease

Inflammation and oxidative stress play a key role in the pathophysiology of advanced chronic liver disease (ACLD) and portal hypertension (PH). Considering the current lack of effective treatments, we evaluated an anti-inflammatory and antioxidant nutraceutical rich in docosahexaenoic acid (DHA) as a possible therapy for ACLD. We investigated the effects of two-week DHA supplementation (500 mg/kg) on hepatic fatty acids, PH, oxidative stress, inflammation, and hepatic stellate cell (HSC) phenotype in rats with ACLD. Additionally, the effects of DHA were evaluated in murine macrophages and human HSC. In contrast to vehicle-treated animals, cirrhotic rats receiving DHA reestablished a healthy hepatic fatty acid profile, which was associated with an improvement in PH. The mechanisms underlying this hemodynamic improvement included a reduction in oxidative stress and inflammation, as well as a marked HSC deactivation, confirmed in human HSC. Experiments with cultured macrophages showed that treatment with DHA protects against pro-inflammatory insults. The present preclinical study demonstrates that a nutraceutical rich in DHA significantly improves PH in chronic liver disease mainly by suppressing inflammation and oxidative stress-driven HSC activation, encouraging its evaluation as a new treatment for PH and cirrhosis

Association between adherence to the Mediterranean diet and waist-to-height ratio among high-risk subjects: the PREDIMED trial.

Trabajo presentado en European Congress of Epidemiology EUROEPI2012, celebrado en Oporto (Portugal) del 05 al 08 de septiembre de 2012.Association between adherence to the Mediterranean diet and waist-to-height ratio among high-risk subjects: the PREDIMED trial

Association Between Classic Cardiovascular Risk Factors and Mortality in the Predimed Trial

Trabajo presentado en World Forum for Nutrition Research Conference, celebrado en Reus (España) del 20 al 21 de mayo de 2013