2,408 research outputs found
Bayesian sequential change diagnosis
Sequential change diagnosis is the joint problem of detection and
identification of a sudden and unobservable change in the distribution of a
random sequence. In this problem, the common probability law of a sequence of
i.i.d. random variables suddenly changes at some disorder time to one of
finitely many alternatives. This disorder time marks the start of a new regime,
whose fingerprint is the new law of observations. Both the disorder time and
the identity of the new regime are unknown and unobservable. The objective is
to detect the regime-change as soon as possible, and, at the same time, to
determine its identity as accurately as possible. Prompt and correct diagnosis
is crucial for quick execution of the most appropriate measures in response to
the new regime, as in fault detection and isolation in industrial processes,
and target detection and identification in national defense. The problem is
formulated in a Bayesian framework. An optimal sequential decision strategy is
found, and an accurate numerical scheme is described for its implementation.
Geometrical properties of the optimal strategy are illustrated via numerical
examples. The traditional problems of Bayesian change-detection and Bayesian
sequential multi-hypothesis testing are solved as special cases. In addition, a
solution is obtained for the problem of detection and identification of
component failure(s) in a system with suspended animation
Attraction between like-charged colloidal particles induced by a surface a density - functional analysis
We show that the first non-linear correction to the linearised
Poisson-Boltzman n (or DLVO) theory of effective pair interactions between
charge-stabilised, co lloidal particles near a charged wall leads to an
attractive component of entro pic origin. The position and depth of the
potential compare favourably with rec ent experimental measurementsComment: 12 pages including 2 figures. submitted to physical review letter
Effect of many-body interactions on the solid-liquid phase-behavior of charge-stabilized colloidal suspensions
The solid-liquid phase-diagram of charge-stabilized colloidal suspensions is
calculated using a technique that combines a continuous Poisson-Boltzmann
description for the microscopic electrolyte ions with a molecular-dynamics
simulation for the macroionic colloidal spheres. While correlations between the
microions are neglected in this approach, many-body interactions between the
colloids are fully included. The solid-liquid transition is determined at a
high colloid volume fraction where many-body interactions are expected to be
strong. With a view to the Derjaguin-Landau-Verwey-Overbeek theory predicting
that colloids interact via Yukawa pair-potentials, we compare our results with
the phase diagram of a simple Yukawa liquid. Good agreement is found at high
salt conditions, while at low ionic strength considerable deviations are
observed. By calculating effective colloid-colloid pair-interactions it is
demonstrated that these differences are due to many-body interactions. We
suggest a density-dependent pair-potential in the form of a truncated Yukawa
potential, and show that it offers a considerably improved description of the
solid-liquid phase-behavior of concentrated colloidal suspensions
Helicon Plasma Injector and Ion Cyclotron Acceleration Development in the VASIMR Experiment
In the Variable Specific Impulse Magnetoplasma Rocket (VASIMR) radio frequency (rf) waves both produce the plasma and then accelerate the ions. The plasma production is done by action of helicon waves. These waves are circular polarized waves in the direction of the electron gyromotion. The ion acceleration is performed by ion cyclotron resonant frequency (ICRF) acceleration. The Advanced Space Propulsion Laboratory (ASPL) is actively developing efficient helicon plasma production and ICRF acceleration. The VASIMR experimental device at the ASPL is called VX-10. It is configured to demonstrate the plasma production and acceleration at the 10kW level to support a space flight demonstration design. The VX-10 consists of three electromagnets integrated into a vacuum chamber that produce magnetic fields up to 0.5 Tesla. Magnetic field shaping is achieved by independent magnet current control and placement of the magnets. We have generated both helium and hydrogen high density (>10(exp 18) cu m) discharges with the helicon source. ICRF experiments are underway. This paper describes the VX-10 device, presents recent results and discusses future plans
Concentration of atomic hydrogen diffused into silicon in the temperature range 900–1300 °C
Boron-doped Czochralski silicon samples with [B]~1017 cm−3 have been heated at various temperatures in the range 800–1300 °C in an atmosphere of hydrogen and then quenched. The concentration of [H-B] pairs was measured by infrared localized vibrational mode spectroscopy. It was concluded that the solubility of atomic hydrogen is greater than [Hs] = 5.6 × 1018 exp( − 0.95 eV/kT)cm−3 at the temperatures investigated
Differential modulation of annexin I binding sites on monocytes and neutrophils.
Specific binding sites for the anti-inflammatory protein annexin I have been detected on the surface of human monocytes and polymorphonuclear leukocytes (PMN). These binding sites are proteinaceous in nature and are sensitive to cleavage by the proteolytic enzymes trypsin, collagenase, elastase and cathepsin G. When monocytes and PMN were isolated independently from peripheral blood, only the monocytes exhibited constitutive annexin I binding. However PMN acquired the capacity to bind annexin I following co-culture with monocytes. PMN incubation with sodium azide, but not protease inhibitors, partially blocked this process. A similar increase in annexin I binding capacity was also detected in PMN following adhesion to endothelial monolayers. We propose that a juxtacrine activation rather than a cleavage-mediated transfer is involved in this process. Removal of annexin I binding sites from monocytes with elastase rendered monocytes functionally insensitive to full length annexin I or to the annexin I-derived pharmacophore, peptide Ac2-26, assessed as suppression of the respiratory burst. These data indicate that the annexin I binding site on phagocytic cells may have an important function in the feedback control of the inflammatory response and their loss through cleavage could potentiate such responses
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