Gluino-mediated electroweak penguin with flavor-violating trilinear couplings

In light of a discrepancy of the direct $CP$ violation in $K\to\pi\pi$ decays, $\varepsilon'/\varepsilon_K$, we investigate gluino contributions to the electroweak penguin, where flavor violations are induced by squark trilinear couplings. Top-Yukawa contributions to $\Delta S = 2$ observables are taken into account, and vacuum stability conditions are evaluated in detail. It is found that this scenario can explain the discrepancy of $\varepsilon'/\varepsilon_K$ for the squark mass smaller than 5.6 TeV. We also show that the gluino contributions can amplify $\mathcal{B}(K \to \pi \nu \overline{\nu})$, $\mathcal{B}(K_S \to \mu^+ \mu^-)_{\rm eff}$ and $\Delta A_{\rm CP}(b\to s\gamma)$. Such large effects could be measured in future experiments.Comment: 30 pages, 8 figures; references added, version published in JHE

Metastatic Small Intestinal Cancer of the Urinary Bladder

We report an extremely rare case of small intestinal cancer metastasized to the urinary bladder, presenting a urologic symptom. A 41-year-old man first presented with nausea, vomiting and abdominal pain. Based on the clinical diagnosis of jejunal cancer, he underwent a partial resection of the jejunum with lymph node dissection. The pathological diagnosis was moderately differentiated adenocarcinoma of the jejunum, pT4N0. Seventeen months after surgery, he presented with a gross hematuria. Computed tomographic scan showed wall thickening of the posterior wall of the urinary bladder. No tumor was found in other organs or lymph nodes. Based on histological and immunohistochemical analysis, the diagnosis of urinary bladder metastasis from jejunal adenocarcinoma was made. This is the first report of urinary bladder metastasis from small intestinal cancer. Although very rare, the possibility of metastatic small intestinal cancer should be considered in differential diagnosis in patients with adenocarcinoma involving the urinary bladder

The Subaru FMOS Galaxy Redshift Survey (FastSound). II. The Emission Line Catalog and Properties of Emission Line Galaxies

We present basic properties of $\sim$3,300 emission line galaxies detected by the FastSound survey, which are mostly H$\alpha$ emitters at $z \sim$ 1.2-1.5 in the total area of about 20 deg$^2$, with the H$\alpha$ flux sensitivity limit of $\sim 1.6 \times 10^{-16} \rm erg \ cm^{-2} s^{-1}$ at 4.5 sigma. This paper presents the catalogs of the FastSound emission lines and galaxies, which will be open to the public in the near future. We also present basic properties of typical FastSound H$\alpha$ emitters, which have H$\alpha$ luminosities of $10^{41.8}$-$10^{43.3}$ erg/s, SFRs of 20--500 $M_\odot$/yr, and stellar masses of $10^{10.0}$--$10^{11.3}$ $M_\odot$. The 3D distribution maps for the four fields of CFHTLS W1--4 are presented, clearly showing large scale clustering of galaxies at the scale of $\sim$ 100--600 comoving Mpc. Based on 1,105 galaxies with detections of multiple emission lines, we estimate that contamination of non-H$\alpha$ lines is about 4% in the single-line emission galaxies, which are mostly [OIII]$\lambda$5007. This contamination fraction is also confirmed by the stacked spectrum of all the FastSound spectra, in which H$\alpha$, [NII]$\lambda \lambda$6548,6583, [SII]$\lambda \lambda$6717, 6731, and [OI]$\lambda \lambda$6300,6364 are seen.Comment: 17 pages, 15 figures, accepted for publication in PAS

Fermi level tuning of Ag-doped Bi2Se3 topological insulator

The temperature dependence of the resistivity (rho) of Ag-doped Bi2Se3 (AgxBi2-xSe3) shows insulating behavior above 35 K, but below 35 K, rho suddenly decreases with decreasing temperature, in contrast to the metallic behavior for non-doped Bi2Se3 at 1.5-300 K. This significant change in transport properties from metallic behavior clearly shows that the Ag doping of Bi2Se3 can effectively tune the Fermi level downward. The Hall effect measurement shows that carrier is still electron in AgxBi2-xSe3 and the electron density changes with temperature to reasonably explain the transport properties. Furthermore, the positive gating of AgxBi2-xSe3 provides metallic behavior that is similar to that of non-doped Bi2Se3, indicating a successful upward tuning of the Fermi level

Blastocyst complementation using Prdm14-deficient rats enables efficient germline transmission and generation of functional mouse spermatids in rats.

Murine animal models from genetically modified pluripotent stem cells (PSCs) are essential for functional genomics and biomedical research, which require germline transmission for the establishment of colonies. However, the quality of PSCs, and donor-host cell competition in chimeras often present strong barriers for germline transmission. Here, we report efficient germline transmission of recalcitrant PSCs via blastocyst complementation, a method to compensate for missing tissues or organs in genetically modified animals via blastocyst injection of PSCs. We show that blastocysts from germline-deficient Prdm14 knockout rats provide a niche for the development of gametes originating entirely from the donor PSCs without any detriment to somatic development. We demonstrate the potential of this approach by creating PSC-derived Pax2/Pax8 double mutant anephric rats, and rescuing germline transmission of a PSC carrying a mouse artificial chromosome. Furthermore, we generate mouse PSC-derived functional spermatids in rats, which provides a proof-of-principle for the generation of xenogenic gametes in vivo. We believe this approach will become a useful system for generating PSC-derived germ cells in the future

14-3-3 proteins stabilize LGI1-ADAM22 levels to regulate seizure thresholds in mice

新たなてんかん治療戦略を提案 --脳の過剰興奮を阻止するタンパク質ADAM22の量が鍵--. 京都大学プレスリリース. 2021-12-15.What percentage of the protein function is required to prevent disease symptoms is a fundamental question in genetic disorders. Decreased transsynaptic LGI1-ADAM22 protein complexes, because of their mutations or autoantibodies, cause epilepsy and amnesia. However, it remains unclear how LGI1-ADAM22 levels are regulated and how much LGI1-ADAM22 function is required. Here, by genetic and structural analysis, we demonstrate that quantitative dual phosphorylation of ADAM22 by protein kinase A (PKA) mediates high-affinity binding of ADAM22 to dimerized 14-3-3. This interaction protects LGI1-ADAM22 from endocytosis-dependent degradation. Accordingly, forskolin-induced PKA activation increases ADAM22 levels. Leveraging a series of ADAM22 and LGI1 hypomorphic mice, we find that ∼50% of LGI1 and ∼10% of ADAM22 levels are sufficient to prevent lethal epilepsy. Furthermore, ADAM22 function is required in excitatory and inhibitory neurons. These results suggest strategies to increase LGI1-ADAM22 complexes over the required levels by targeting PKA or 14-3-3 for epilepsy treatment

Galaxy clustering and projected density profiles as traced by satellites in photometric surveys: Methodology and luminosity dependence

We develop a new method which measures the projected density distribution w_p(r_p)n of photometric galaxies surrounding a set of spectroscopically-identified galaxies, and simultaneously the projected correlation function w_p(r_p) between the two populations. In this method we are able to divide the photometric galaxies into subsamples in luminosity intervals when redshift information is unavailable, enabling us to measure w_p(r_p)n and w_p(r_p) as a function of not only the luminosity of the spectroscopic galaxy, but also that of the photometric galaxy. Extensive tests show that our method can measure w_p(r_p) in a statistically unbiased way. The accuracy of the measurement depends on the validity of the assumption in the method that the foreground/background galaxies are randomly distributed and thus uncorrelated with those galaxies of interest. Therefore, our method can be applied to the cases where foreground/background galaxies are distributed in large volumes, which is usually valid in real observations. We applied our method to data from SDSS including a sample of 10^5 LRGs at z~0.4 and a sample of about half a million galaxies at z~0.1, both of which are cross-correlated with a deep photometric sample drawn from the SDSS. On large scales, the relative bias factor of galaxies measured from w_p(r_p) at z~0.4 depends on luminosity in a manner similar to what is found at z~0.1, which are usually probed by autocorrelations of spectroscopic samples. On scales smaller than a few Mpc and at both z~0.4 and z~0.1, the photometric galaxies of different luminosities exhibit similar density profiles around spectroscopic galaxies at fixed luminosity and redshift. This provides clear support for the assumption commonly-adopted in HOD models that satellite galaxies of different luminosities are distributed in a similar way, following the dark matter distribution within their host halos.Comment: 38 pages, 12 figures, published in Ap

Digital quantitative analysis of mast cell infiltration in interstitial cystitis

AimsTo evaluate the significance of mast cell infiltration in interstitial cystitis (IC) by comparison with equally inflamed controls using a digital quantification technique. MethodsBladder biopsy specimens from 31 patients with Hunner type IC and 38 patients with non-Hunner type IC were analyzed. Bladder biopsy specimens from 37 patients without IC, including 19 non-specific chronic cystitis (non-IC cystitis) specimens and 18 non-inflamed bladder (normal bladder) specimens, were used as controls. Mast cell tryptase-, CD3-, CD20-, and CD138-immunoreactive cells were quantified using digital image analysis software to evaluate both mast cell and lymphoplasmacytic cell densities. Mast cell and lymphoplasmacytic cell densities were counted independently in the entire lamina propria and detrusor areas and compared among the four groups. ResultsIn the lamina propria, there were no significant differences in mast cell and lymphoplasmacytic cell densities between Hunner type IC and non-IC cystitis or between non-Hunner type IC and normal bladder specimens. In the detrusor, the mast cell densities were not significantly different among the four groups. Mast cell density was correlated with lymphoplasmacytic cell density, but not with clinical parameters. ConclusionsMast cell density is not significantly different between IC specimens and non-IC control specimens with a similar degree of background inflammation. The intensity of mast cell infiltration generally correlated with that of lymphoplasmacytic cells. We conclude that mast cell count is of no value in the differential diagnosis between IC and other etiologies

Prophylactic clip closure for mucosal defects is associated with reduced adverse events after colorectal endoscopic submucosal dissection: a propensity-score matching analysis

博士（医学）乙日本医科大学202