Thyrotoxic pretibial myxoedema in Asian patients in Singapore

Over a 5-year period, three cases of thyrotoxic pretibial myxoedema were encountered. The incidence of pretibial myxoedema in Chinese thyrotoxic patients in Singapore was 0·7% (0·3% in females and 1·6% in males). One of the three patients also had thyroid acropachy. The incidence of thyrotoxic pretibial myxoedema in Singapore is compared with that in the literature and the aetiology briefly reviewed

Molecular systematics of teioid lizards (Teioidea/Gymnophthalmoidea: Squamata) based on the analysis of 48 loci under tree-alignment and similarity-alignment

We infer phylogenetic relationships within Teioidea, a superfamily of Nearctic and Neotropical lizards, using nucleotide sequences. Phylogenetic analyses relied on parsimony under tree-alignment and similarity-alignment, with length variation (i.e. gaps) treated as evidence and as absence of evidence, and maximum-likelihood under similarity-alignment with gaps as absence of evidence. All analyses produced almost completely resolved trees despite 86% of missing data. Tree-alignment produced the shortest trees, the strict consensus of which is more similar to the maximum-likelihood tree than to any of the other parsimony trees, in terms of both number of clades shared, parsimony cost and likelihood scores. Comparisons of tree costs suggest that the pattern of indels inferred by similarity-alignment drove parsimony analyses on similarity-aligned sequences away from more optimal solutions. All analyses agree in a majority of clades, although they differ from each other in unique ways, suggesting that neither the criterion of optimality, alignment nor treatment of indels alone can explain all differences. Parsimony rejects the monophyly of Gymnophthalmidae due to the position of Alopoglossinae relative to Teiidae, whereas support of Gymnophthalmidae by maximum-likelihood was low. We address various nomenclatural issues, including Gymnophthalmidae Fitzinger, 1826 being an older name than Teiidae Gray, 1827. We recognize three families in the arrangement Alopoglossidae + (Teiidae + Gymnophthalmidae). Within Gymnophthalmidae we recognize Cercosaurinae, Gymnophthalminae, Rhachisaurinae and Riolaminae in the relationship Cercosaurinae + (Rhachisaurinae + (Riolaminae + Gymnophthalminae)). Cercosaurinae is composed of three tribes—Bachiini, Cercosaurini and Ecpleopodini—and Gymnophthalminae is composed of three—Gymnophthalmini, Heterodactylini and Iphisini. Within Teiidae we retain the currently recognized three subfamilies in the arrangement: Callopistinae + (Tupinambinae + Teiinae). We also propose several genus-level changes to restore the monophyly of taxa.This study was funded by the Spanish Ministry of Science and Innovation Projects CGL2008-04164 and CLG2011-30393 (I. De La Riva, PI), and CGL2010-21250 and CGL2011-30393 (Carles Vila, PI),Peer Reviewe