Age Related Changes in Cerebrovascular Reactivity and Its Relationship to Global Brain Structure

ACKNOWLEDGMENTS This study was funded by Alzheimer’s Research UK (ARUK) and the Aberdeen Biomedical Imaging Centre, University of Aberdeen. GDW, ADM and CS are part of the SINASPE collaboration (Scottish Imaging Network - A Platform for Scientific Excellence www.SINAPSE.ac.uk). The authors thank Gordon Buchan, Baljit Jagpal, Nichola Crouch, Beverly Maclennan and Katrina Klaasen for their help with running the experiment and Dawn Younie and Teresa Morris for their help with recruitment and scheduling. We also thank the residents of Aberdeen and Aberdeenshire, and further afield, for their generous participation.Peer reviewedPublisher PD

Neural indicators of fatigue in chronic diseases : A systematic review of MRI studies

The authors would like to thank the Sir Jules Thorn Charitable Trust for their financial support.Peer reviewedPublisher PD

KPP reaction-diffusion equations with a non-linear loss inside a cylinder

We consider in this paper a reaction-diffusion system in presence of a flow and under a KPP hypothesis. While the case of a single-equation has been extensively studied since the pioneering Kolmogorov-Petrovski-Piskunov paper, the study of the corresponding system with a Lewis number not equal to 1 is still quite open. Here, we will prove some results about the existence of travelling fronts and generalized travelling fronts solutions of such a system with the presence of a non-linear spacedependent loss term inside the domain. In particular, we will point out the existence of a minimal speed, above which any real value is an admissible speed. We will also give some spreading results for initial conditions decaying exponentially at infinity

Candida albicans colonization and dissemination from the murine gastrointestinal tract : the influence of morphology and Th17 immunity

This article is protected by copyright. All rights reserved. This work was supported by the Wellcome Trust (086558, 080088, 102705), a Wellcome Trust Strategic Award (097377) and a studentship from the University of Aberdeen. D.K. was supported by grant 5R01AI083344 from the National Institute of Allergy and Infectious Diseases and by a Voelcker Young Investigator Award from the Max and Minnie Tomerlin Voelcker Fund.Peer reviewedPublisher PD

Comparison of Boltzmann Kinetics with Quantum Dynamics for a Chiral Yukawa Model Far From Equilibrium

Boltzmann equations are often used to describe the non-equilibrium time-evolution of many-body systems in particle physics. Prominent examples are the computation of the baryon asymmetry of the universe and the evolution of the quark-gluon plasma after a relativistic heavy ion collision. However, Boltzmann equations are only a classical approximation of the quantum thermalization process, which is described by so-called Kadanoff-Baym equations. This raises the question how reliable Boltzmann equations are as approximations to the complete Kadanoff-Baym equations. Therefore, we present in this article a detailed comparison of Boltzmann and Kadanoff-Baym equations in the framework of a chirally invariant Yukawa-type quantum field theory including fermions and scalars. The obtained numerical results reveal significant differences between both types of equations. Apart from quantitative differences, on a qualitative level the late-time universality respected by Kadanoff-Baym equations is severely restricted in the case of Boltzmann equations. Furthermore, Kadanoff-Baym equations strongly separate the time scales between kinetic and chemical equilibration. In contrast to this standard Boltzmann equations cannot describe the process of quantum-chemical equilibration, and consequently also cannot feature the above separation of time scales.Comment: 17 pages, 8 figures, REVTeX

Update on the Surgical Trial in Lobar Intracerebral Haemorrhage (STICH II):Statistical analysis plan

<p>Abstract</p> <p>Background</p> <p>Previous studies had suggested that the outcome for patients with spontaneous lobar intracerebral haemorrhage (ICH) and no intraventricular haemorrhage (IVH) might be improved with early evacuation of the haematoma. The Surgical Trial in Lobar Intracerebral Haemorrhage (STICH II) set out to establish whether a policy of earlier surgical evacuation of the haematoma in selected patients with spontaneous lobar ICH would improve outcome compared to a policy of initial conservative treatment. It is an international, multi-centre, prospective randomised parallel group trial of early surgery in patients with spontaneous lobar ICH. Outcome is measured at six months via a postal questionnaire.</p> <p>Results</p> <p>Recruitment to the study began on 27 November 2006 and closed on 15 August 2012 by which time 601 patients had been recruited. The protocol was published in <it>Trials</it> (<url>http://www.trialsjournal.com/content/12/1/124/</url>). This update presents the analysis plan for the study without reference to the unblinded data. The trial data will not be unblinded until after follow-up is completed in early 2013. The main trial results will be presented in spring 2013 with the aim to publish in a peer-reviewed journal at the same time.</p> <p>Conclusion</p> <p>The data from the trial will provide evidence on the benefits and risks of early surgery in patients with lobar ICH.</p> <p>Trial registration</p> <p>ISRCTN: ISRCTN22153967</p

Low Resolution Spectral Templates For AGNs and Galaxies From 0.03 -- 30 microns

We present a set of low resolution empirical SED templates for AGNs and galaxies in the wavelength range from 0.03 to 30 microns based on the multi-wavelength photometric observations of the NOAO Deep-Wide Field Survey Bootes field and the spectroscopic observations of the AGN and Galaxy Evolution Survey. Our training sample is comprised of 14448 galaxies in the redshift range 0<~z<~1 and 5347 likely AGNs in the range 0<~z<~5.58. We use our templates to determine photometric redshifts for galaxies and AGNs. While they are relatively accurate for galaxies, their accuracies for AGNs are a strong function of the luminosity ratio between the AGN and galaxy components. Somewhat surprisingly, the relative luminosities of the AGN and its host are well determined even when the photometric redshift is significantly in error. We also use our templates to study the mid-IR AGN selection criteria developed by Stern et al.(2005) and Lacy et al.(2004). We find that the Stern et al.(2005) criteria suffers from significant incompleteness when there is a strong host galaxy component and at z =~ 4.5, when the broad Halpha emission line is redshifted into the [3.6] band, but that it is little contaminated by low and intermediate redshift galaxies. The Lacy et al.(2004) criterion is not affected by incompleteness at z =~ 4.5 and is somewhat less affected by strong galaxy host components, but is heavily contaminated by low redshift star forming galaxies. Finally, we use our templates to predict the color-color distribution of sources in the upcoming WISE mission and define a color criterion to select AGNs analogous to those developed for IRAC photometry. We estimate that in between 640,000 and 1,700,000 AGNs will be identified by these criteria, but will have serious completeness problems for z >~ 3.4.Comment: Accepted for publication in The Astrophysical Journal. 26 text pages + 3 tables + 20 figures, modified to include comments made by the referee. Fortran codes, templates and electronic tables available at http://www.astronomy.ohio-state.edu/~rjassef/lrt