Age at first birth in women is genetically associated with increased risk of schizophrenia

Prof. Paunio on PGC:n jäsenPrevious studies have shown an increased risk for mental health problems in children born to both younger and older parents compared to children of average-aged parents. We previously used a novel design to reveal a latent mechanism of genetic association between schizophrenia and age at first birth in women (AFB). Here, we use independent data from the UK Biobank (N = 38,892) to replicate the finding of an association between predicted genetic risk of schizophrenia and AFB in women, and to estimate the genetic correlation between schizophrenia and AFB in women stratified into younger and older groups. We find evidence for an association between predicted genetic risk of schizophrenia and AFB in women (P-value = 1.12E-05), and we show genetic heterogeneity between younger and older AFB groups (P-value = 3.45E-03). The genetic correlation between schizophrenia and AFB in the younger AFB group is -0.16 (SE = 0.04) while that between schizophrenia and AFB in the older AFB group is 0.14 (SE = 0.08). Our results suggest that early, and perhaps also late, age at first birth in women is associated with increased genetic risk for schizophrenia in the UK Biobank sample. These findings contribute new insights into factors contributing to the complex bio-social risk architecture underpinning the association between parental age and offspring mental health.Peer reviewe

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Not AvailableThe study was carried out to compare various two- parameter probability distributions for identifying the most appropriate distribution to describe the weekly rainfall data of standard meteorological week (SMW) from 22 to 42 weeks in Shivalik region of India. The "best" distribution among different data sets has been identified using Anderson Darling (AD) test for goodness - of- ut. Single probability distribution which can represent all the data sets, was not found among the distributions studied. Weibull distribution was best fit in about nine SMW , followed by Gamma distribution showing best fits in 7 weeks out of the 21 weeks studied. Comparing total rainfall at different probability level with average rainfall , it was found that minimum assured rainfall with 50, 40 and 30 % probability is 21.35% lesser , o=0.04% higher and 37.25% higher , respectively than average rainfall. Thus, minimum assured weekly rainfall at 40% probability level is better representative of long - term average weekly rainfall data of the region. Appropriate time for maize sowing should be between 25th june to 1st july as minimum assured rainfall of more than 25 mm is available with 70% probability. It was found that only short to medium duration maize varieties are suitable taking into account the rainfall pattern and duration in the region.Not Availabl

Weekly rainfall analysis for crop planning in rainfed Shivalik Himalayas of India

The study was carried out to compare various two-parameter probability distributions for identifying the most appropriate distribution to describe the weekly rainfall data of Standard Meteorological Week (SMW) from 22 to 42 weeks in Shivalik region of India. The ‘‘best’’ distribution among different data sets has been identiûed using Anderson–Darling (AD) test for goodness-of-ût. Single probability distribution, which can represent all the data sets, was not found among the distributions studied. Weibull distribution was best fit in about nine SMW, followed by Gamma distribution showing best fit in seven weeks out of the 21 weeks studied. Comparing total rainfall at different probability level with average rainfall, it was found that minimum assured rainfall with 50, 40 and 30 per cent probability is 21.35 % lesser, 0.04 % higher and 37.25 % higher, respectively than average rainfall. Thus minimum assured weekly rainfall at 40% probability level is a better representative of long-term average weekly rainfall data of the region. Appropriate time for maize sowing should be between 25th June to 1st July as minimum assured rainfall of more than 25 mm is available with 70 per cent probability. It was found that only short to medium duration maize varieties are suitable taking into account the rainfall pattern and duration in the region.