Masa muscular, fuerza isométrica y dinámica en las extremidades inferiores de niños y adolescentes con síndrome de Down

En general se ha observado que las personas con síndrome de Down (SD) tienen valores inferiores de fuerza muscular comparados con personas sin SD. También existe un déficit de masa muscular en los adultos con SD comparados con otros sin SD. Sin embargo, ningún estudio hasta la fecha había evaluado esta masa muscular en población pediátrica. Nuestro estudio pretende poner de manifiesto si también a edades tempranas existe un déficit de masa muscular y además relacionar ambos valores. Los niños y adolescentes con y sin SD (15±3 y 14±3 años respectivamente) de nuestro estudio obtuvieron valores similares de masa muscular ajustada por talla y estadio puberal, pero el grupo con SD obtuvo valores inferiores de fuerza (p<0.05). Además de esto, el grupo con SD ejerció menos kilogramos de fuerza por cada kilogramo de masa muscular. Alguna causa fisiológica o de transmisión podría explicar esta falta de fuerza ya que, al menos en esta franja de edad no existe un déficit de masa muscular. Deberían incentivarse los programas de entrenamiento específicos para este tipo de población para comprobar si es posible un incremento en su fuerza muscular.Generally it has been observed that population with Down syndrome (DS) has lower levels of muscular strength compared with others without DS. It is also known a deficit between muscular mass between adults with and without DS. However, there are no studies until the date which evaluated muscular mass in paediatric populations. Our study pretends to show whether also in earlier ages it does exist a deficit in the muscular mass and also to relate both values. Children and adolescents with and without DS (15±3 y 14±3 years respectively) from the study had similar values of muscular mass adjusted by height and puberal status, but DS group obtained lower values in all strength parameters. In addition, DS group also performed less kilograms of strength by kilogram of muscular mass. Some physiological or transmission impairment could explain this lack of strength as it known that there are not deficit in the muscular mass. Specific and adapted for this population training programs should be promoted to check whether an enhancement in their muscular strength is possible.Peer Reviewe

Hand span influences optimal grip span in adolescents with Down syndrome

Introduction: The hand grip strength test provides useful and reliable information about overall health. Different studies have investigated the optimal grip span for determining maximal hand grip strength in different populations such as adults, adolescents and children without disabilities. Objective: To ascertain whether there is an optimal grip span for determining maximal hand grip strength in adolescents with Down syndrome (DS). Methods: Twenty-seven right-handed youths with DS (seven females) aged 15.5 ± 3.6 years were evaluated in this methodological study. Each hand was randomly tested on ten times using five different grip spans, allowing one-minute rest between attempts. The hand span was measured from the tip of the thumb to the tip of the small finger with the hand widely opened. To confirm the usefulness of the optimal grip span, a new group of 15 adolescents with DS were recruited. Results: An optimal grip span was identified for the dominant hand in adolescents with DS. The equation relating grip span as a function of dominant hand span in this group is formulated as follows: y = 0.342x - 1.161 cm (r = 0.63, p < 0.05). In the case of non-dominant hand, a tendency towards a linear association (p = 0.058) was found; the equation is formulated as follows: y = 0, 210x + 1.324 cm. Conclusion: It is important to standardize the procedure and increase reliability when measuring hand grip strength in DS population. The values stated in this study are recommended to assess hand grip strength in adolescents with Down syndrome

Association of physical activity levels and prevalence of major degenerative diseases: Evidence from the national health and nutrition examination survey (NHANES) 1999–2018

Objectives: Degenerative diseases are associated with lower healthy life expectancy and higher mortality. Physical activity (PA) has demonstrated a fundamental role in the prevention and control of several pathologies associated to the aging process. The aim of this study was to analyze the association of PA with the prevalence of sarcopenia, osteoporosis and osteoarthritis in non-institutionalized American population. Methods: Cross-sectional study carried out in participants aged ≥50 years from the 1999–2018 National Health and Nutrition Examination Survey (NHANES). Sarcopenia was defined using appendicular lean mass adjusted for body mass index (ALM:BMI; men 1800 MET-min/week was associated with reduced odds for osteoporosis; and performing 150–1800 MET-min/week of PA was associated with reduced odds for osteoarthritis after adjust the results by several confounders. Conclusions: The benefits of PA in sarcopenia, osteoporosis, and osteoarthritis prevention are evident among Americans aged ≥50 years

A cross-sectional analysis of the association between physical activity, depression, and all-cause mortality in Americans over 50 years old

Depression is estimated to be the second leading cause of disability in the United States and is associated with a 52% increased risk of death. Lifestyle components may have an important role in depression pathogenesis. The aims of this study were to analyze the association of meeting the physical activity (PA) recommendation guidelines and depression, and to analyze the all-cause mortality risk of the joint association of PA and depression. This cross-sectional study included 7201 participants from the 2007–2014 National Health and Nutrition Examination Survey aged ≥ 50 years and linked to National Death Index records through December 31, 2015. Depression was defined as a score ≥ 10 using the Patient Health Questionnaire (PHQ-9). PA was self-reported, and total PA was used to classify participants as more active (≥ 600 MET-min/week) or less active (&lt; 600 MET-min/week). The odds ratios for depression were examined according to be more active or less active. The hazard ratios (HR) for the association of PA level and depression status with all-cause mortality were examined. Being more active was associated with reduced odds for depression. Compared with less active participants with depression, those who were more active and having depression had HR 0.45 (95% CI 0.22, 0.91, p = 0.026) for all-cause mortality. Being more active is associated with lower odds for depression and seems to be a protective factor against the increased all-cause mortality risk due to depression

Effect of whole-body vibration training on bone mass in adolescents with and without Down syndrome: a randomized controlled trial

Summary: Whole-body vibration training (WBV) attracts great interest as osteoporosis prevention strategy. Twenty-six adolescents with and without Down syndrome (DS) (13 DS//12–18 years) performed 20 weeks of WBV. The results indicate that WBV seems to provoke a lesser response in adolescents with DS than in those without DS. Introduction: This study aims to observe the differences between adolescents with and without DS in the effects of 20 weeks of WBV training, on bone mineral content (BMC) and density (BMD). Methods: Twenty-six adolescents (13 DS//12–18 years) were measured with dual-energy X-ray absorptiometry before and after the intervention (3/week, 10 repetitions (30–60 s) and 1-min rest, frequency 25–30 Hz and peak-to-peak displacement of 2 mm (peak acceleration 2.5–3.6 g)). Both, an intention-to-treat (ITT) analysis designed to assess the effects on bone mass and a per-protocol analysis, designed to compare poor and high compliers, were performed. Results: The ITT analysis revealed significant increases in all BMC and BMD parameters (dz = 0.66 to 1.64//all p < 0.05) in the non-DS group, whilst DS group improved whole-body, subtotal (whole-body less head), upper limbs (ULIMBS), pelvis, lower limbs (LLIMBS) and spine BMC (dz = 0.75 to 1.76//all p < 0.05) and subtotal, pelvis, LLIMBS and spine BMD (dz = 0.73 to 1.28//all p < 0.05). Significantly greater increases were evident in the absolute and percent changes of the non-DS group over DS group (d = 0.88 to 3.85//all p < 0.05). ULIMBS BMD showed a tendency towards an interaction (f = 0.41 and p = 0.086) with higher increase for non-DS group. When a per-protocol analysis was considered, high-complier adolescents had 8.1 versus 5.3 % of gains in the spine BMC over poor-complier adolescents (d = 0.93//p < 0.05). Conclusions: Twenty weeks of WBV training may improve BMC and BMD in clinically relevant skeletal sites in both groups. Nevertheless, this type of training seems to provoke a lesser response in adolescents with DS than in those without DS

Plyometric exercise and bone health in children and adolescents: a systematic review

Background: Many jumping interventions have been performed in children and adolescents in order to improve bone-related variables and thus, ensure a healthy bone development during these periods and later in life. This systematic review aims to summarize and update present knowledge regarding the effects that jumping interventions may have on bone mass, structure and metabolism in order to ascertain the efficacy and durability (duration of the effects caused by the intervention) of the interventions. Methods: Identification of studies was performed by searching in the database MEDLINE/PubMed and SportDiscus. Additional studies were identified by contacting clinical experts and searching bibliographies and abstracts. Search terms included “bone and bones”, “jump*”, “weight-bearing”, “resistance training” and “school intervention”. The search was conducted up to October 2014. Only studies that had performed a specific jumping intervention in under 18-year olds and had measured bone mass were included. Independent extraction of articles was done by 2 authors using predefined data fields. Results: A total of 26 studies were included in this review. Twenty-four studies found positive results as subjects included in the intervention groups showed higher bone mineral density, bone mineral content and bone structure improvements than controls. Only two studies found no effects on bone mass after a 10-week and 9-month intervention. Moreover, those studies that evaluated the durability of the effects found that some of the increases in the intervention groups were maintained after several years. Conclusion: Jumping interventions during childhood and adolescence improve bone mineral content, density and structural properties without side effects. These type of interventions should be therefore implemented when possible in order to increase bone mass in early stages of life, which may have a direct preventive effect on bone diseases like osteoporosis later in life

Is Playing Soccer More Osteogenic for Females Before the Pubertal Spurt?

The aims of this study were to assess bone mass in children and adolescent soccer players and to evaluate the influence of both gender and pubertal status on bone mass. A total of 110 soccer players (75 males / 35 females; 12.73 ± 0.65 / 12.76 ± 0.59 years) participated in this cross-sectional study. They were divided into two groups according to their pubertal status. Bone and lean masses were measured with Dual-energy X-ray Absorptiometry. An independent t-test and an adjusted by subtotal lean and training experience multivariate analysis of covariance were used to analyse the differences in bone mass values between genders and maturity status. Female soccer players presented higher bone mass values than their male counterparts in most of the measured weight-bearing sites. Moreover, when stratifying by pubertal status, peripubertal and postpubertal females had higher subtotal body and lumbar spine bone mass than males. Comparing between pubertal status groups before adjustment, both male and female postpubertal players showed higher bone mass than their pubertal counterparts. After adjusting, these differences disappeared and, in fact results were inverted as bone mass at the femoral neck was higher in both male and female peripubertal soccer players than in postpubertal players. Bone mass seems to be more intensely stimulated by playing soccer in female than male players, particularly in the lumbar spine. The results of peripubertal players showing higher bone mass at the femoral neck after adjusting suggest that playing soccer during the peripubertal stage could be an effective activity to achieve optimal bone mass values

Voice Conversion Using K-Histograms and Residual Averaging

The main goal of a voice conversion system is to modify the voice of a source speaker, in order to be perceived as if it had been uttered by another specific speaker.   Many approaches found in the literature convert only the features related to the vocal tract of the speaker. Our proposal is to convert those characteristics of the vocal tract, and also to process the signal passing through the vocal chords. Thus, the goal of this work is to obtain better scores in the voice conversion results.Fil: Uriz, Alejandro José. Universidad Nacional de Mar del Plata. Facultad de Ingenieria. Departamento de Electronica. Laboratorio de Comunicaciones; ArgentinaFil: Pablo D. Agüero. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - Mar del Plata;Fil: Castiñeira Moreira; Jorge. Universidad Nacional de Mar del Plata. Facultad de Ingenieria. Departamento de Electronica. Laboratorio de Comunicaciones;Fil: Tulli, J. C.. Universidad Nacional de Mar del Plata. Facultad de Ingenieria. Departamento de Electronica. Laboratorio de Comunicaciones; ArgentinaFil: González, Esteban Lucio. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - Mar del Plata; ArgentinaFil: Bonafonte, A.. Universidad Nacional de Mar del Plata. Facultad de Ingenieria. Departamento de Electronica. Laboratorio de Comunicaciones; Argentin

Agreement of body composition methods in elite male football referees

Objective: The current literature about the body composition of elite football referees is scarce and almost non-existent. Therefore, and in order to establish the level of agreement between bioelectrical impedance analysis (BIA) and dual energy X-ray absorptiometry (DXA) in elite football referees, the aim of this study was to compare fat mass (FM) and fat-free mass (FFM) values measured with these two different methods. Method: A total of 30 male referees belonging to 1st, 2nd and 2ndB categories, and 36 assistant referees from 1st and 2nd categories in the Spanish national league participated in this study. Total and regional FM and FFM were assessed using a portable BIA analyser TANITA BC 418-MA (Tanita Corp., Tokyo, Japan) and DXA (Hologic Corp. Software version 12.4, Bedford, MA 01730). Agreement between methods was assessed by plotting the results in Bland-Altman graphs and the presence of heteroscedasticity was also examined. Differences between methods were analysed by two-paired samples t-test. Results: For the whole group, BIA underestimated body fat percentage in 3.87 points (CI 95%=3.22-4.52; p=&lt;0.01) and overestimated kg of total FFM in 3.56 points (CI 95%=3.08-4.05; p=&lt;0.01), however, no heteroscedasticity was shown in any case (all p&gt;0.05). Conclusions: The present study suggests that according to DXA, BIA values calculated with a non-specific equation are underestimating total FM and, consequently, overestimating total FFM in male elite football referees. Objetivo: La literatura científica existente sobre la composición corporal en árbitros de fútbol es todavía escasa. Por lo tanto y para establecer el nivel de concordancia entre el análisis de impedancia bioeléctrica y la absorciometría de rayos X de doble energía en árbitros de fútbol de elite, el objetivo de este estudio fue comparar los valores de masa grasa (MG) y la masa libre de grasa (MLG) medidos con ambos métodos. Método: Un total de 30 árbitros pertenecientes a las categorías de 1ª, 2ª y 2ª división B, y 36 asistentes de 1ª y 2ª división de la liga española participaron en este estudio. La MG y la MLG tanto a nivel total como regional se evaluó utilizando la impedancia bioeléctrica TANITA BC 418-MA (Tanita Corp., Tokyo, Japan) y absorciometría de rayos X de doble energía (Hologic Corp. Software versión 12.4, Bedford, MA 01730). La concordancia entre métodos se evaluó con gráficos de Bland-Altman y también se examinó la presencia de heterocedasticidad. Las diferencias entre métodos se analizaron con la prueba T de Student para muestras relacionadas. Resultados: Para el total de la muestra, la impedancia bioeléctrica infraestimó el porcentaje de MG en 3.87 puntos (IC 95%=3.22-4.52; p=0.05). Conclusión: El presente estudio sugiere que, tomando como referencia la absorciometría de rayos X de doble energía, la impedancia bioeléctrica calculada a partir de una ecuación no especifica para árbitros, infraestima la MG y consecuentemente, sobreestima la MLG en árbitros de fútbol de elite

Cross-talk between signaling pathways: The link between plant secondary metabolite production and wounding stress response

Plants subjected to wounding stress produce secondary metabolites. Several of these metabolites prevent chronic diseases and can be used as colorants, flavors, and as antimicrobials. This wound-induced production of plant secondary metabolites is mediated by signaling-molecules such as reactive oxygen species (ROS), ethylene (ET) and jasmonic acid (JA). However, their specific role and interactions that modulate the wound-respond in plants is not fully understood. In the present study, a subtractive cDNA library was generated, to better understand the global response of plants to wounding stress. Carrot (Daucus carota) was used as a model system for this study. A total of 335 unique expressed sequence tags (ESTs) sequences were obtained. ESTs sequences with a putative identity showed involvement in stress-signaling pathways as well as on the primary and secondary metabolism. Inhibitors of ROS biosynthesis, ET action, and JA biosynthesis alone and in combination were applied to wounded-carrots in order to determine, based on relative gene expression data, the regulatory role of ET, JA, and ROS on the wound-response in plants. Our results demonstrate that ROS play a key role as signaling-molecules for the wound-induced activation of the primary and secondary metabolism whereas ET and JA are essential to modulate ROS levels