El aumento de la escolarización en Educación Infantil y la disminución de las tasas de abandono temprano: dos indicadores que favorecen las políticas de inclusión

No se entiende hoy un sistema educativo de calidad si no incluye políticas encaminadas a mejorar las oportunidades educativas de todos los estudiantes. En todos los casos, los sistemas deben evolucionar favoreciendo las características personales y, a la vez, integrando las diferencias económicas, sociales, culturales, religiosas de cada país. Esta pluralidad solo tendrá verdadero sentido si se presentan como oportunidades y, en definitiva, como un camino necesario para lograr la inclusión, para mejorar y evolucionar. Para que cada sociedad alcance una mayor igualdad, tanto la educación como la formación juegan un papel determinante. En la Unión Europea, la Comisión en materia de educación y formación ha propuesto, de cara al 2020, la consecución de seis objetivos. Entre ellos se anuncia la importancia que tiene mejorar la escolarización de las etapas de educación infantil así como las tasas de abandono prematuro. Concretamente, en el próximo bienio, las cifras de niños y niñas en edad preescolar de más de cuatro años deben alcanzar el 95% y, por otro lado, se debe lograr reducir por debajo del 10%, el abandono temprano de escolares en la educación y la formación. Este estudio analiza estos dos indicadores, viendo su evolución en diversos países y reconociendo la relevancia que pueden tener ambos, ya directa o indirectamente, en los procesos de inclusión y en su optimización. Aumentando el primero y disminuyendo el segundo se favorecen las medidas relacionadas con la proporcionalidad y la equidad educativa. La elección de estos dos ámbitos tiene su explicación en el propio concepto de inclusión y en las dimensiones asociadas al mismo. ¿Sería acertado indicar que aquellos países que tienen mejores cifras en materia de educación infantil y de abandono temprano tienen también mejores datos acerca de la calidad educativa y, por consiguiente, en materia de inclusión? Buscamos algunos ejemplos que nos ayuden a entender y explicar estos argumentos aunque, realmente, no parece oportuno considerarlos como hechos absolutos pero sí relacionados.A quality education system needs to include policies aimed at improving the educational opportunities of all students. The development of education systems should promote personal characteristics in all cases while, at the same time, integrating the economic, social, cultural, and religious differences within each country. This diversity will only have real meaning if it is presented as an opportunity and ultimately, as a necessary inclusionary path for improvement and growth. Education and training play a decisive role in achieving greater social equality. In the European Union, the Education and Training Commission has proposed six benchmarks to be met by 2020. These include improving schooling provision for the early stages of primary education, as well as improving early drop-out rates. Specifically, in the next two years, at least 95% of children (from 4 to compulsory school age) should participate in early childhood education school; and the rate of early leavers from education and training aged 18-24 should be below 10%. This study analyses these two indicators by looking at how they have fared in different countries and recognising their direct or indirect impact in the optimisation of inclusion processes. Increasing the first indicator while decreasing the second encourages measures related to proportionality and educational equality. The choice of these two areas can be explained by the concept of inclusion and its associated dimensions. Would it be accurate to say that those countries that have better figures in terms of early childhood educa - tion and early school drop-out rates also have better data in terms of educational quality and, consequently, of inclusion? This paper provides some examples to gain a better understanding of these arguments, since it does not seem appropriate to consider them in isolation but rather as interrelated aspect

Dynamics of CaCdc10, a septin of Candida albicans, in living cells and during infection

The morphogenetic program in the pathogenic fungus Candida albicans , including the dimorphic transition, is an interesting field of study, not only because it is absent in the commonly used model yeast Saccharomyces cerevisiae, but because of the close relationship between hyphal development and virulence of C. albicans. We studied one of the most important aspects of fungal morphogenesis-the septin ring–in C. albicans. By using a fusion construct to green fluorescent protein (GFP), the subcellular localization and dynamics of C. albicans Cdc10 in the different morphologies that this fungus is able to adopt was identified. The localization features reached were contrasted and compared with the results obtained from Candida cells directly extracted from an animal infection model under environmental conditions as similar as possible to the physiological conditions encountered by C. albicans during host infection. [Int Microbiol 2004; 7(2):105–112

Metabolic Serendipities of Expanded Newborn Screening

Incidental findings on newborn screening (NBS) are results that are not the target of screening within a given NBS program, but rather are found as a result of the screening and resulting diagnostic workup for that target. These findings may not have an immediate clinical impact on the newborn, but are sometimes an additional benefit of NBS programs and may be considered secondary targets of NBS programs. This work describes four case reports that had incidental findings on the NBS, which eventually led to the diagnosis of another metabolic disease instead of the one that was initially suspected. The first case was a new defect in the cationic amino acid transporter-2 (CAT-2), which was oriented as an arginase-1 deficiency in the newborn. The second case was a maternal glutaric aciduria type 1 (GA-1) that mimicked a carnitine transporter deficiency in the newborn. The third report was a case of lysinuric protein intolerance (LPI), which appeared as high levels of citrulline on the NBS. The fourth case was a mother with homocystinuria that was diagnosed during the biochemical study of vitamin B12 status. All cases provide new or interesting data that will help guide differential diagnosis in the future.Financial support was provided by grant PI19/01155 and the European Regional Development Fun

Sex Differences and Predictors of In-Hospital Mortality among Patients with COVID-19: Results from the ANCOHVID Multicentre Study

Spain is one of the countries most affected by the COVID-19 pandemic. Although risk factors for severe disease are published, sex differences have been widely neglected. In this multicentre study, we aimed to identify predictors of in-hospital mortality in men and women hospitalised with COVID-19. An observational longitudinal study was conducted in the cohort of patients admitted to four hospitals in Andalusia, Spain, from 1 March 2020 to 15 April 2020. Sociodemographic and clinical data were collected from hospital records. The Kaplan–Meier method was used to estimate 30-day survival and multiple Cox regression models were applied. All analyses were stratified by sex. A total of 968 patients were included (54.8% men, median age 67.0 years). In-hospital mortality reached 19.1% in men and 16.0% in women. Factors independently associated with an increased hazard of death were advanced age, higher CURB-65 score and not receiving azithromycin treatment, in both sexes; active cancer and autoimmune disease, in men; cardiovascular disease and chronic lung disease, in women. Disease outcomes and predictors of death differed between sexes. In-hospital mortality was higher in men, but the long-term effects of COVID-19 merit further research. The sex-differential impact of the pandemic should be addressed in public health policies

Distribution and biogeographic trends of decapod assemblages from Galicia Bank (NE Atlantic) at depths between 700 and 1800m, with connexions to regional water masses

The GaliciaBank(NEAtlantic,42167′N–11174′W) isanisolatedseamount,nearNWSpain,acomplex geomorphological andsedimentarystructurethatreceivesinfluences fromcontrastingwatermassesof both northernandsouthernorigins.WithintheprojectINDEMARES,threecruiseswereperformedon the bankin2009(Ecomarg0709),2010(BanGal0810)and2011(BanGal0811)allinJuly–August. Decapods andothermacrobenthiccrustaceans(eucaridsandperacarids)werecollectedwithdifferent sampling systems,mainlybeamtrawls(BT,10mmofmeshsizeatcodend)andaGOC73ottertrawl (20 mmmeshsize).Sixty-sevenspeciesofdecapodcrustaceans,6euphausiids,19peracaridsand 1 ostracodwerecollectedatdepthsbetween744and1808m.Wefoundtwonewspecies,oneamember of theChirostylidae, Uroptychuscartesi Baba &Macpherson,2012,theotherofthePetalophthalmidae (Mysida) Petalophthalmus sp. A,inadditiontoanumberofnewbiogeographicspeciesrecordsfor European orIberianwaters.Ananalysisofassemblagesshowedageneralizedspeciesrenewalwith depth, withdifferentassemblagesbetween744and ca. 1400m(theseamounttopassemblage,STA)and between ca. 1500and1800m(thedeep-slopeassemblageoverseamount flanks,DSA).Thesewere respectivelyassociatedwithMediterraneanoutflow waters(MOW)andwithLabradorSeaWater(LSW). Another significant factorseparatingdifferentassemblagesovertheGalicianBankwastheco-occurrence of corals(bothcoloniesofhardcoralssuchas Lophelia pertusa and Madreporaoculata and/or gorgonians) in hauls.Munidopsids(Munidopsis spp.), chirostylids(Uroptychus spp.), andthehomolodromiid Dicranodromiamahieuxii formed apartofthiscoral-associatedassemblage.Dominantspeciesatthe STAwerethepandalid Plesionika martia (a shrimpofsubtropical-southerndistribution)andthecrabs Bathynectes maravigna and Polybiushenslowii, whereasdominantspeciesintheDSAwereofnorthern origin, thelithodid Neolithodes grimaldii and thecrangonid Glyphocrangonlongiristris, likelyassociated with LSW.Thediversity(H and J) ofsmallcrustaceans(collectedwithBT)seemedtobecontrolledbythe phytoplanktonblooms(satelliteChl a data) overbanksurface3monthsbeforethesamplings,bothatthe top (Spearman r¼0.57, p¼0.03) andonthe flanks (r¼0.74, p¼0.02) ofGaliciaBank,whilenosignificant relationships withChl a werefoundforthelargerdecapodscollectedwithGOC73,onaveragetheyfeed at thehighertrophiclevelsthanthosecollectedwithBT.Postprin

Transcriptomic and Metabolomic Response to High Light in the Charophyte Alga Klebsormidium nitens

The characterization of the molecular mechanisms, such as high light irradiance resistance, that allowed plant terrestralization is a cornerstone in evolutionary studies since the conquest of land by plants played a pivotal role in life evolution on Earth. Viridiplantae or the green lineage is divided into two clades, Chlorophyta and Streptophyta, that in turn splits into Embryophyta or land plants and Charophyta. Charophyta are used in evolutionary studies on plant terrestralization since they are generally accepted as the extant algal species most closely related to current land plants. In this study, we have chosen the facultative terrestrial early charophyte alga Klebsormidium nitens to perform an integrative transcriptomic and metabolomic analysis under high light in order to unveil key mechanisms involved in the early steps of plants terrestralization. We found a fast chloroplast retrograde signaling possibly mediated by reactive oxygen species and the inositol polyphosphate 1-phosphatase (SAL1) and 3′-phosphoadenosine-5′-phosphate (PAP) pathways inducing gene expression and accumulation of specific metabolites. Systems used by both Chlorophyta and Embryophyta were activated such as the xanthophyll cycle with an accumulation of zeaxanthin and protein folding and repair mechanisms constituted by NADPH-dependent thioredoxin reductases, thioredoxin-disulfide reductases, and peroxiredoxins. Similarly, cyclic electron flow, specifically the pathway dependent on proton gradient regulation 5, was strongly activated under high light. We detected a simultaneous co-activation of the non-photochemical quenching mechanisms based on LHC-like stress related (LHCSR) protein and the photosystem II subunit S that are specific to Chlorophyta and Embryophyta, respectively. Exclusive Embryophyta systems for the synthesis, sensing, and response to the phytohormone auxin were also activated under high light in K. nitens leading to an increase in auxin content with the concomitant accumulation of amino acids such as tryptophan, histidine, and phenylalanine.España Ministerio de Ciencia e Innovación MINOTAUR (BIO2017-84066-R

Advances in seismic monitoring at Deception Island volcano (Antarctica) since the International Polar Year

Deception Island is an active volcano located in the south Shetland Islands, Antarctica. It constitutes a natural laboratory to test geophysical instruments in extreme conditions, since they have to endure not only the Antarctic climate but also the volcanic environment. Deception is one of the most visited places in Antarctica, both by scientists and tourists, which emphasize the importance of volcano monitoring. Seismic monitoring has been going on since 1986 during austral summer surveys. The recorded data include volcano-tectonic earthquakes, long-period events and volcanic tremor, among others. The level of seismicity ranges from quiet periods to seismic crises (e.g. 1992-1993, 1999). Our group has been involved in volcano monitoring at Deception Island since 1994. Based on this experience, in recent years we have made the most of the opportunities of the International Polar Year 2007-2008 to introduce advances in seismic monitoring along four lines: (1) the improvement of the seismic network installed for seismic monitoring during the summer surveys; (2) the development and improvement of seismic arrays for the detection and characterization of seismo-volcanic signals; (3) the design of automated event recognition tools, to simplify the process of data interpretation; and (4) the deployment of permanent seismic stations. These advances help us to obtain more data of better quality, and therefore to improve our interpretation of the seismo-volcanic activity at Deception Island, which is a crucial step in terms of hazards assessment.This work has been partially supported by the projects POL2006-08663, CGL2007-28855, CTM2008-03062, CTM2009-07705, CTM2009-08085 and CTM2010-11740 of the Spanish Ministry of Science and Innovation

Serum vascular endothelial growth factor b and metabolic syndrome incidence in the population based cohort [email protected] study

Background/Objectives Although vascular endothelial growth factor b (VEGFb) might have an impact on the development of obesity, diabetes and related disorders, the possible relationship between VEGFb serum levels and the incidence of these metabolic complications in humans is still unknown. The aim of our study was to evaluate the association between VEGFb serum levels and the new-onset of metabolic syndrome (MS) and its components in the Spanish adult population after 7.5 years of follow-up. Subjects/Methods A total of 908 subjects from the [email protected] cohort study without MS at cross-sectional stage according to International Diabetes Federation (IDF) or Adult Treatment Panel III (ATP-III) criteria were included. Additionally, five sub-populations were grouped according to the absence of each MS component at baseline. Socio-demographic, anthropometric and clinical data were recorded. The Short Form of International Physical Activity Questionnaire (SF-IPAQ) was used to estimate physical activity. A fasting blood extraction and an oral glucose tolerance test were performed. Serum determinations of glucose, lipids, hsCRP and insulin were made. VEGFb levels were determined and categorized according to the 75th percentile of the variable. New cases of MS and its components were defined according to ATPIII and IDF criteria. Results A total of 181 or 146 people developed MS defined by IDF or ATP-III criteria respectively. Serum triglyceride levels, hs-CRP and systolic blood pressure at the baseline study were significantly different according to the VEGFb categories. Adjusted logistic regression analysis showed that the likelihood of developing MS and abdominal obesity was statistically reduced in subjects included in the higher VEGFb category. Conclusion Low serum levels of VEGFb may be considered as early indicators of incident MS and abdominal obesity in the Spanish adult population free of MS, independently of other important predictor variables.This investigation has been supported by CIBERDEM (Ministerio de Economia, Industria y Competitividad-ISCIII), Ministerio de Sanidad, Servicios Sociales e IgualdadISCIII, Instituto de Salud Carlos III (research grants PI20/01322, PI18/01165, PI17/02136, PI14/00710) and cofunding by the European Regional Development Fund (ERDF) "A way to build Europe". LifeScan Espana (Madrid, Spain) kindly donated the glucometers and test strips for capillary glucose measurements. Cristina MaldonadoAraque is a researcher in the `Rio Hortega' program (CM19/00186) financed by the Instituto de Salud Carlos III. Natalia Colomo is a member of the regional "Accion B para clinicos investigadores" research program of the Consejeria de Salud of the Junta de Andalucia, Spain (B-0002-17). Gemma Rojo-Martinez belongs to the Nicolas Monardes research program of the Consejeria de Salud (C-0060-2012; Junta de Andalucia, Spain)