Combination of the three types of diversity to design high capacity compact MIMO terminal

Multiple-input-multiple-output (MIMO) schemes designed to increase channel capacity face strong limitations when a large number of antennas must be deployed in a terminal due to size constrains. This letter discusses how the different combinations of the three types of diversities-namely spatial, radiation pattern, and polarization diversity-can be used to get an improved capacity in compact terminals. The study compares realistic combinations that overcome the need for a large number of radiating elements in the user terminal.This work was supported in part by the Spanish Ministry of Sci-ence and Innovation under Project GRE3NSYST (TEC2011-29006-C03-03), Project TEC2013-44019-R, and the CONSOLIDER-INGENIO 2010 program under Project COMONSENS (CSD 2008-00010).Publicad

Study of cross-sectional shapes of ideally hard cylinders to achieve invisibility for oblique incidence

In this work, the effect of the incidence angle on struts for reducing electromagnetic blockage using ideal hard cylinders in the antenna area is analyzed. Firstly, the characterization of the invisibility of a given object in terms of an equivalent blockage width is discussed. Then, ideally hard cylinders with oblong cross sectional shapes and hard surfaces for different incidence angles are analyzed. It is shown that the variation of incidence angle in azimuth is very sensitive in terms of blockage for TM polarization. Finally, design chart of ideal struts which reduce blockage simultaneously for TE and TM cases that give some performance goals for a final realized struts are presented

Evaluación de los talleres de actividades en materia de seguridad vial en Galicia

Póster presentado en el X Congreso Español de Criminología, 7, 8 y 9 de mayo de 2014, GranadaCon motivo de la modificación del Código penal en materia de seguridad vial (LO 15/2007, de 30 de noviembre), el número de delitos relacionados con el tráfico y la Seguridad Vial han desbordado los medios y posibilidades de conmutar las penas con TBC. Para dar respuesta a este problema el Grupo de Tráfico y Seguridad del Colexio Oficial de Psicoloxía de Galicia propuso en 2008 a Instituciones Penitenciarias un Proyecto Piloto para la realización de unas “Xornadas de Concienciación” en substitución de los TBC. En esta comunicación se presentan algunos resultados de la evaluación de la experiencia realizada en 2011 adaptando las jornadas iniciales al esquema aprobado en la Instrucción I 2/2010/DGCTMA, de 10 de marzo, sobre la gestión administrativa de la pena de trabajos en beneficio de la comunidad contra la seguridad del tráfico: los talleres de actividades en seguridad vial. Se aplicaron cinco grupos en distintas localidades de Galicia a los que asistieron un total de 128 infractores la mayoría de los cuales presentaban delitos relacionados con conducir bajo los efectos del alcohol (64%) o hacerlo sin el permiso de conducir (30%). Para evaluar los efectos de la intervención se aplicó en la sesión inicial (pretest) y en la final (postest) una batería de pruebas en las que se evaluaba compuesta por la escala CRV-SV, el AUDITC y la escala de estados de cambio en la conducción. Los resultados encontrados evidencian mejoras significativas en los participantes que justifican la realización de este tipo de intervenciones substitutivas de las penas de TB

Ultrasonographic assessment of enthesitis in HLA-B27 positive patients with rheumatoid arthritis, a matched case-only study

Introduction HLA-B27 has a modifier effect on the phenotype of multiple diseases, both associated and non-associated with it. Among these effects, an increased frequency of clinical enthesitis in patients with Rheumatoid Arthritis (RA) has been reported but never explored again. We aimed to replicate this study with a sensitive and quantitative assessment of enthesitis by using standardized ultrasonography (US). Methods The Madrid Sonography Enthesitis Index (MASEI) was applied to the US assessment of 41 HLA-B27 positive and 41 matched HLA-B27 negative patients with longstanding RA. Clinical characteristics including explorations aimed to evaluate spondyloarthrtitis and laboratory tests were also done. Results A significant degree of abnormalities in the entheses of the patients with RA were found, but the MASEI values, and each of its components including the Doppler signal, were similar in HLA-B27 positive and negative patients. An increase of the MASEI scores with age was identified. Differences in two clinical features were found: a lower prevalence of rheumatoid factor and a more common story of low back pain in the HLA-B27 positive patients than in the negative. The latter was accompanied by radiographic sacroiliitis in two HLA-B27 positive patients. No other differences were detected. Conclusion We have found that HLA-B27 positive patients with RA do not have more enthesitis as assessed with US than the patients lacking this HLA allele. However, HLA-B27 could be shaping the RA phenotype towards RF seronegativity and axial involvement.The study was supported by grants 10CSA918040PR from the Xunta de Galicia (http://www.sergas.e/MostrarContidos_N3_T01.aspx?IdPaxina=10142) and PI08/0744 of the Instituto de Salud Carlos III (http://www.isciii.es/) that are partially financed by the European Regional Development Fund of the European UnionS

MobyDeep: A lightweight CNN architecture to configure models for text classification

Financiado para publicación en acceso aberto: Universidade de Vigo/CISUGNowadays, trends in deep learning for text classification are addressed to create complex models to deal with huge datasets. Deeper models are usually based on cutting edge neural network architectures, achieving good results in general but demanding better hardware than shallow ones. In this work, a new Convolutional Neural Network (CNN) architecture (MobyDeep) for text classification tasks is proposed. Designed as a configurable tool, resultant models (MobyNets) are able to manage big corpora sizes under low computational costs. To achieve those milestones, the architecture was conceived to produce lightweight models, having their internal layers based on a new proposed convolutional block. That block was designed and customized by adapting ideas from image to text processing, helping to squeezing model sizes and to reduce computational costs. The architecture was also designed as a residual network, covering complex functions by extending models up to 28 layers. Moreover, middle layers were optimized by residual connections, helping to remove fully connected layers on top and resulting in Fully CNN. Corpus were chosen from the recent literature, aiming to define real scenarios when comparing configured MobyDeep models with other state-of the-art works. Thus, three models were configured in 8, 16 and 28 layers respectively, offering competitive accuracy results

Criterios para la asignación de servicios sociales a personas en situación de dependencia

A society that seeks the well-being and quality of life of its citizens should promote policies that ensure social care to everyone, and particularly, to people in situations of dependency. Traditionally, this group has received attention through a network of informal caregivers, but such social network is not always able to cope with the basic needs of people in situations of dependency. It is therefore necessary to organize and/ or strengthen a formal network of support that includes services of different nature (from community-based to residential-based care). The assignment of people to these social services must be done in an objective and systematic way to ensure both an equal access for everyone and also the best fit between the characteristics of those services and the needs of people. In the current study, we analize the variables and criteria that must be taken into account by the different professionals to allocate resources, such as: social support, functional ability or cognitive state. Finally, we offer a decision-making model to ensure unanimity and to facilitate this professional task.Una sociedad que busca el bienestar y la calidad de vida de sus ciudadanos debe promover políticas sociales que garanticen la atención, a todas las personas en general y, en especial, a las personas en situación de dependencia. La atención a este colectivo se ha venido realizando, tradicionalmente, a través de una red de cuidadores informales; pero esta red social no siempre tiene capacidad para hacer frente a las necesidades básicas de las personas en situación de dependencia, haciéndose necesario organizar y/o reforzar una red de apoyo formal que incluya diferentes servicios tanto comunitarios como de tipo residencial. La asignación de las personas a estos recursos debe realizarse de forma objetiva y sistemática a fin de garantizar, tanto la igualdad en el acceso de todas las personas a los recursos sociales, como el máximo ajuste posible entre las características de esos servicios y las necesidades de las personas. En el presente trabajo se analizan las variables y criterios que deben ser tenidos en cuenta por los diferentes profesionales para la asignación de recursos, como lo son: el apoyo social, la capacidad funcional o el estado cognitivo. Se ofrece, por último, un modelo de toma de decisiones que garantice la unanimidad y facilite esta labor profesional

Impact of CYP2C:TG Haplotype on CYP2C19 substrates clearance in vivo, protein content, and in vitro activity

A novel haplotype composed of two non-coding variants, CYP2C18 NM_000772.3:c.*31T (rs2860840) and NM_000772.2:c.819+2182G (rs11188059), referred to as “CYP2C:TG,” was recently associated with ultrarapid metabolism of various CYP2C19 substrates. As the underlying mechanism and clinical relevance of this effect remain uncertain, we analyzed existing in vivo and in vitro data to determine the magnitude of the CYP2C:TG haplotype effect. We assessed variability in pharmacokinetics of CYP2C19 substrates, including citalopram, sertraline, voriconazole, omeprazole, pantoprazole, and rabeprazole in 222 healthy volunteers receiving one of these six drugs. We also determined its impact on CYP2C8, CYP2C9, CYP2C18, and CYP2C19 protein abundance in 135 human liver tissue samples, and on CYP2C18/CYP2C19 activity in vitro using N-desmethyl atomoxetine formation. No effects were observed according to CYP2C:TG haplotype or to CYP2C19*1+TG alleles (i.e., CYP2C19 alleles containing the CYP2C:TG haplotype). In contrast, CYP2C19 intermediate (e.g., CYP2C19*1/*2) and poor metabolizers (e.g., CYP2C19*2/*2) showed significantly higher exposure in vivo, lower CYP2C19 protein abundance in human liver microsomes, and lower activity in vitro compared with normal, rapid (i.e., CYP2C19*1/*17), and ultrarapid metabolizers (i.e., CYP2C19*17/*17). Moreover, a tendency toward lower exposure was observed in ultrarapid metabolizers compared with rapid metabolizers and normal metabolizers. Furthermore, when the CYP2C19*17 allele was present, CYP2C18 protein abundance was increased suggesting that genetic variation in CYP2C19 may be relevant to the overall metabolism of certain drugs by regulating not only its expression levels, but also those of CYP2C18. Considering all available data, we conclude that there is insufficient evidence supporting clinical CYP2C:TG testing to inform drug therapyP.S.-C. is financed by Universidad Autónoma de Madrid (FPIUAM, 2021). P.Z. is financed by Universidad Autónoma de Madrid, Margarita Salas contract, grants for the requalification of the Spanish university system. A.R.-L. and E.G.-I. contracts are financed by Programa Investigo (NextGenerationEU funds of the Recovery and Resilience Facility), fellowship numbers 2022-C23.I01.P03. S0020–0000031 and 09-PIN1-00015.6/2022. Human liver tissue samples were obtained through the Liver Tissue Cell Distribution System, Minneapolis, MN, and Pittsburgh, PA, which was funded by NIH Contract #HHSN276201200017C. The proteomics part of the work was supported by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH) Grant R01.HD08129

The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells through the upregulation of NOXA and synergizes with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax

Fluorizoline is a new synthetic molecule that induces apoptosis by selectively targeting prohibitins. In the study herein, the pro-apoptotic effect of fluorizoline was assessed in 34 primary samples from patients with chronic lymphocytic leukemia. Fluorizoline induced apoptosis in chronic lymphocytic leukemia cells at concentrations in the low micromolar range. All primary samples were sensitive to fluorizoline irrespective of patients' clinical or genetic features, whereas normal T lymphocytes were less sensitive. Fluorizoline increased the protein levels of the pro-apoptotic B-cell lymphoma 2 family member NOXA in chronic lymphocytic leukemia cells. Furthermore, fluorizoline synergized with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax to induce apoptosis. These results suggest that targeting prohibitins could be a new therapeutic strategy for chronic lymphocytic leukemia

The presence of Merkel cell carcinoma polyomavirus is associated with a distinct phenotype in neoplastic Merkel cell carcinoma cells and their tissue microenvironment

Aims: Merkel cell carcinoma (MCC) is an aggressive primary neuroendocrine tumor of the skin, associated with Merkel cell polyomavirus (MCPyV) in 49-89% of cases, depending on the country of origin and the techniques of detection. The presence of MCPyV defines heterogeneity in MCC; MCPyV-negative cases bear a much higher mutational load, with a distinct ultraviolet signature pattern featuring C > T transitions, as a consequence of exposure to ultraviolet light radiation. MCC stroma has not been thoroughly studied, although MCC patients benefit from therapy targeting PD1/PDL1. Methods and results: In this study, using Tissue Microarrays and immunohistochemistry, we have analyzed a series of 219 MCC cases in relation to the presence of MCPyV, and confirmed that the presence of MCPyV is associated with changes not only in the neoplastic cells, but also in the composition of the tumor stroma. Thus, MCPyV, found in 101/176 (57,4%) analyzable cases, exhibits changes in its tumor morphology, the density of the inflammatory infiltrate, the phenotype of the neoplastic cells, and the cell composition of the tumor stroma. MCPyV presence is negatively correlated with a higher level of p53 expression, and associated with a very high frequency (86%) of HLA-I expression loss, a higher apoptotic index, and a stroma richer in T-cells, cytotoxic T-cells, macrophages, PDL1-positive macrophages, and B-cells. Conclusions: Our findings provide evidence of the basic heterogeneity of MCC, supporting the hypothesis that the presence of MCPyV may induce a rich inflammatory response, which is at least partially avoided through loss of HLA-I antigen expression. On the other hand, MCPyV-negative cases show a much higher frequency of stronger p53 expression and, probably, p53 alterations.Dr. Piris is the principal investigator of all the projects funding this study. This work was supported by grants from the Instituto de Salud Carlos III (ISCIII) of the Spanish Ministry of Economy and Competence (MINECO, RTICC ISCIII and CIBERONC) (SAF2013-47416-R, RD06/0020/0107-RD012/0036/0060 and Plan Nacional I+D+I: PI17/2172, PI16/01294 and PIE15/0081), AECC, and the Madrid Autonomous Community