Concrete in high-rise buildings: practical experiences in Madrid

The use of concrete in high-rise buildings has increased significantly in the last 20 years mainly owing to improvement in all of the technologies associated with this material: admixtures, pumping, transportation and elevation methods, etc. These enhanced possibilities are illustrated by means of four high-rise buildings that were built recently in Madrid, each about 250 m high. The main structural elements of these buildings are presented focusing on the advantages offered by concrete compared to other materials that are commonly used in high-rise construction. The types of concrete considered are high-resistance concrete up to C80, self-compacting concrete, precast and in situ concrete, reinforced or prestressed concrete, as well as normal weight or lightweight concrete. These examples clearly show that, even in structures where the role of self weight is determinant, concrete can be the best solution if all of the different factors involved in the success of a construction site are considered: geometry, ease of construction, means of elevation, prefabrication at factory, repetitiveness, material costs, control requirements, and so o

Label-free electrical detection of DNA hybridization using carbon nanotubes and graphene

The interface between biosystems and nanomaterials is emerging for detection of various biomolecules and subtle cellular activities. In particular, the development of cost-effective and sequence-selective DNA detection is urgent for the diagnosis of genetic or pathogenic diseases. Graphene-based nanocarbon materials, such as carbon nanotubes and thin graphene layers, have been employed as biosensors because they are biocompatible, extraordinarily sensitive, and promising for large-area detection. Electrical and label-free detection of DNA can be achieved by monitoring the conductance change of devices fabricated from these carbon materials. Here, the recent advances in this research area are briefly reviewed. The key issues and perspectives of future development are also discussed

Atmospheric gravitational tides of Earth-like planets orbiting low-mass stars

Temperate terrestrial planets orbiting low-mass stars are subject to strong tidal forces. The effects of gravitational tides on the solid planet and that of atmospheric thermal tides have been studied, but the direct impact of gravitational tides on the atmosphere itself has so far been ignored. We first develop a simplified analytic theory of tides acting on the atmosphere of a planet. We then implement gravitational tides into a general circulation model of a static-ocean planet in a short-period orbit around a low-mass star -- the results agree with our analytic theory. Because atmospheric tides and solid-body tides share a scaling with the semi-major axis, we show that there is a maximum amplitude of the atmospheric tide that a terrestrial planet can experience while still having a solid surface; Proxima Centauri b is the poster child for a planet that could be geophysically Earth-like but with atmospheric tides more than 500$\times$ stronger than Earth's. In this most extreme scenario, we show that atmospheric tides significantly impact the planet's meteorology -- but not its climate. Two possible modest climate impacts are enhanced longitudinal heat transport and cooling of the lowest atmospheric layers. The strong radiative forcing of such planets dominates over gravitational tides, unlike moons of cold giant planets, such as Titan. We speculate that atmospheric tides could be climatologically important on planets where the altitude of maximal tidal forcing coincides with the altitude of cloud formation and that the effect could be detectable for non-Earth-like planets subject to even greater tides

Remnants of Sagittarius Dwarf Spheroidal Galaxy around the young globular cluster Palomar 12

Photometry of a large field around the young globular cluster Palomar 12 has revealed the main-sequence of a low surface-brightness stellar system. This main-sequence is indicative of a stellar population that varies significantly in metallicity and/or age, but in the mean is more metal poor than Pal 12. Under different assumptions for the properties of this population, we find distances from the Sun in the range 17-24 kpc, which encompasses the distance to Pal 12, $19.0\pm0.9$ kpc. The stellar system is also detected in a field 2\arcdeg North of Pal 12, which indicates it has a minimum diameter of $\sim0.9$ kpc. The orbit of Pal 12 (Dinescu et al. 2000), the color-magnitude diagram of the stellar system, their positions on the sky, and their distances suggest that they are debris from the tidal disruption of the Sgr dSph galaxy. We discuss briefly the implications for the evolution of Sgr and the Galactic halo.Comment: 16 pages, 2 figures, accepted for ApJ Letters. Some importante changes after revision, including a new figur

Dependence on the Identification of the Scale Energy Parameter Q 2 in the Quark Distribution Functions for a DIS Production of Za

We discuss the Z-production in a DIS (Deep Inelastic Scattering) process e + p → e + Z + X using the Parton Model, within the context of the Standard Model. In contrast with deep inelastic eP-scattering (e + p → e + X), where the choice of Q2, as the transferred momentum squared, is unambiguous; whereas in the case of boson production , the transferred momentum squared, at quark level, depends on the reaction mechanism (where is the EW interaction taking place). We suggest a proposal based on kinematics of the process considered and the usual criterion for Q2 , which leads to a simple and practical prescription to calculate Z-production via ep-DIS. We also introduce different options in order o perform the convolution of the parton distribution functions (PDFs) and the scattering amplitude of he quark processes. Our aim in this work is to analyze and show how large could be the dependence of the total cross section rates on different possible prescriptions used for the identification of the scale energy parameter Q2 . We present results for the total cross section as a function of the total energy √s of the system ep, in the range 300 <√s ≤ 1300 Ge

Paper-based chromatic toxicity bioassay by analysis of bacterial ferricyanide reduction

Water quality assessment requires a continuous and strict analysis of samples to guarantee compliance with established standards. Nowadays, the increasing number of pollutants and their synergistic effects lead to the development general toxicity bioassays capable to analyse water pollution as a whole. Current general toxicity methods, e.g. Microtox®, rely on long operation protocols, the use of complex and expensive instrumentation and sample pre-treatment, which should be transported to the laboratory for analysis. These requirements delay sample analysis and hence, the response to avoid an environmental catastrophe. In an attempt to solve it, a fast (15 min) and low-cost toxicity bioassay based on the chromatic changes associated to bacterial ferricyanide reduction is here presented. E. coli cells (used as model bacteria) were stably trapped on low-cost paper matrices (cellulose-based paper discs, PDs) and remained viable for long times (1 month at -20 °C). Apart from bacterial carrier, paper matrices also acted as a fluidic element, allowing fluid management without the need of external pumps. Bioassay evaluation was performed using copper as model toxic agent. Chromatic changes associated to bacterial ferricyanide reduction were determined by three different transduction methods, i.e. (i) optical reflectometry (as reference method), (ii) image analysis and (iii) visual inspection. In all cases, bioassay results (in terms of half maximal effective concentrations, EC50) were in agreement with already reported data, confirming the good performance of the bioassay. The validation of the bioassay was performed by analysis of real samples from natural sources, which were analysed and compared with a reference method (i.e. Microtox). Obtained results showed agreement for about 70% of toxic samples and 80% of non-toxic samples, which may validate the use of this simple and quick protocol in the determination of general toxicity. The minimum instrumentation requirements and the simplicity of the bioassay open the possibility of in-situ water toxicity assessment with a fast and low-cost protocolPostprint (author's final draft

Outcome of protease inhibitor substitution with nevirapine in HIV-1 infected children

<p>Abstract</p> <p>Background</p> <p>Protease inhibitors (PIs) have been associated with metabolic complications. There is a trend to switch to simpler therapy to improve these disturbances. We report a case-series describing the effects in metabolic abnormalities in seven HIV-infected children, previously treated with protease inhibitor (PI) after switching to nevirapine.</p> <p>Methods</p> <p>Seven children with stable PI-containing regimen and a long lasting HIV-1 RNA < 50 copies/ml were switched to nevirapine. All patients were naïve to non nucleoside reverse transcriptase inhibitor. PIs were switched to nevirapine. Preentry nucleoside reverse transcriptase inhibitors were maintained. The substitution of PIs with nevirapine was made when the patient showed hyperlipidemia or lipodystrophy or the physician and/or the patient's willingness to simplify. Clinical, laboratory data and anthropometric parameters were assessed every 3 months. Dual-energy X-Ray absorptiometry scans (DXA) was performed at baseline and at 12 months.</p> <p>Results</p> <p>Seven HIV-infected children were enrolled. Median age: 130 months (99,177). Median baseline CD4%: 32%. All had HIV-1 RNA < 50 copies/ml. Median length of preentry PI-therapy was 47 months (28, 91). Median age at the beginning of nevirapine was 120 months (99,177). Median decrease in cholesterol in 7.2 mmol/L was observed (P = 0.09), from baseline to 12 months. HDL-cholesterol increased in 5.1 mmol/L (P = 0.03) throughout the study period. No significant changes were observed in DXA with regard to body fat, but changes in total body bone mineral content and lean body content were significant. CD4% remained stable. All patients but one maintained viral load < 50 copies/ml at 12 months. The patient with virologic failure referred bad adherence. Children referred to take medication more easily.</p> <p>Conclusion</p> <p>PI substitution with nevirapine improved lipid profile in our patients, although this strategy did not show significant changes in body fat or lipodystrophy.</p

Star Cluster collisions - a formation scenario for the Extended Globular Cluster Scl-dE1 GC1

Recent observations of the dwarf elliptical galaxy Scl-dE1 (Sc22) in the Sculptor group of galaxies revealed an extended globular cluster (Scl-dE1 GC1), which exhibits an extremely large core radius of about 21.2 pc. The authors of the discovery paper speculated on whether this object could reside in its own dark matter halo and/or if it might have formed through the merging of two or more star clusters. In this paper, we present N-body simulations to explore thoroughly this particular formation scenario. We follow the merger of two star clusters within dark matter haloes of a range of masses (as well as in the absence of a dark matter halo). In order to obtain a remnant which resembles the observed extended star cluster, we find that the star formation efficiency has to be quite high (around 33 per cent) and the dark matter halo, if present at all, has to be of very low mass, i.e. raising the mass to light ratio of the object within the body of the stellar distribution by at most a factor of a few. We also find that expansion of a single star cluster following mass loss provides another viable formation path. Finally, we show that future measurements of the velocity dispersion of this system may be able to distinguish between the various scenarios we have explored.Comment: accepted by MNRAS, 9 pages, 2 figures, 9 table

Mechanical properties of freely suspended atomically thin dielectric layers of mica

We have studied the elastic deformation of freely suspended atomically thin sheets of muscovite mica, a widely used electrical insulator in its bulk form. Using an atomic force microscope, we carried out bending test experiments to determine the Young's modulus and the initial pre-tension of mica nanosheets with thicknesses ranging from 14 layers down to just one bilayer. We found that their Young's modulus is high (190 GPa), in agreement with the bulk value, which indicates that the exfoliation procedure employed to fabricate these nanolayers does not introduce a noticeable amount of defects. Additionally, ultrathin mica shows low pre-strain and can withstand reversible deformations up to tens of nanometers without breaking. The low pre-tension and high Young's modulus and breaking force found in these ultrathin mica layers demonstrates their prospective use as a complement for graphene in applications requiring flexible insulating materials or as reinforcement in nanocomposites.Comment: 9 pages, 5 figures, selected as cover of Nano Research, Volume 5, Number 8 (2012