1,388 research outputs found
Nonclassical correlations of phase noise and photon number in quantum nondemolition measurements
The continuous transition from a low resolution quantum nondemolition
measurement of light field intensity to a precise measurement of photon number
is described using a generalized measurement postulate. In the intermediate
regime, quantization appears as a weak modulation of measurement probability.
In this regime, the measurement result is strongly correlated with the amount
of phase decoherence introduced by the measurement interaction. In particular,
the accidental observation of half integer photon numbers preserves phase
coherence in the light field, while the accidental observation of quantized
values increases decoherence. The quantum mechanical nature of this correlation
is discussed and the implications for the general interpretation of
quantization are considered.Comment: 16 pages, 5 figures, final version to be published in Phys. Rev. A,
Clarifications of the nature of the measurement result and the noise added in
section I
Recurrence for discrete time unitary evolutions
We consider quantum dynamical systems specified by a unitary operator U and
an initial state vector \phi. In each step the unitary is followed by a
projective measurement checking whether the system has returned to the initial
state. We call the system recurrent if this eventually happens with probability
one. We show that recurrence is equivalent to the absence of an absolutely
continuous part from the spectral measure of U with respect to \phi. We also
show that in the recurrent case the expected first return time is an integer or
infinite, for which we give a topological interpretation. A key role in our
theory is played by the first arrival amplitudes, which turn out to be the
(complex conjugated) Taylor coefficients of the Schur function of the spectral
measure. On the one hand, this provides a direct dynamical interpretation of
these coefficients; on the other hand it links our definition of first return
times to a large body of mathematical literature.Comment: 27 pages, 5 figures, typos correcte
Input-output theory for fermions in an atom cavity
We generalize the quantum optical input-output theory developed for optical
cavities to ultracold fermionic atoms confined in a trapping potential, which
forms an "atom cavity". In order to account for the Pauli exclusion principle,
quantum Langevin equations for all cavity modes are derived. The dissipative
part of these multi-mode Langevin equations includes a coupling between cavity
modes. We also derive a set of boundary conditions for the Fermi field that
relate the output fields to the input fields and the field radiated by the
cavity. Starting from a constant uniform current of fermions incident on one
side of the cavity, we use the boundary conditions to calculate the occupation
numbers and current density for the fermions that are reflected and transmitted
by the cavity
Ground State and Quasiparticle Spectrum of a Two Component Bose-Einstein Condensate
We consider a dilute atomic Bose-Einstein condensate with two non-degenerate
internal energy levels. The presence of an external radiation field can result
in new ground states for the condensate which result from the lowering of the
condensate energy due to the interaction energy with the field. In this
approach there are no instabilities in the quasiparticle spectrum as was
previously found by Goldstein and Meystre (Phys. Rev. A \QTR{bf}{55}, 2935
(1997)).Comment: 20 pages, 2 figures RevTex. Submitted to Phys. Rev. A; Revised
versio
Slow fluctuations in enhanced Raman scattering and surface roughness relaxation
We propose an explanation for the recently measured slow fluctuations and
``blinking'' in the surface enhanced Raman scattering (SERS) spectrum of single
molecules adsorbed on a silver colloidal particle. We suggest that these
fluctuations may be related to the dynamic relaxation of the surface roughness
on the nanometer scale and show that there are two classes of roughness with
qualitatively different dynamics. The predictions agree with measurements of
surface roughness relaxation. Using a theoretical model for the kinetics of
surface roughness relaxation in the presence of charges and optical electrical
fields, we predict that the high-frequency electromagnetic field increases both
the effective surface tension and the surface diffusion constant and thus
accelerates the surface smoothing kinetics and time scale of the Raman
fluctuations in manner that is linear with the laser power intensity, while the
addition of salt retards the surface relaxation kinetics and increases the time
scale of the fluctuations. These predictions are in qualitative agreement with
the Raman experiments
Association between somatic cell count and serial locomotion score assessments in UK dairy cows
This research investigated the effect of lameness, measured by locomotion score (LS) on the somatic cell count (SCC) of UK dairy cows. The data set consisted of 11,141 records of SCC and LS collected monthly on 12 occasions from 1,397 cows kept on 7 farms. The data were analyzed to account for the correlation of repeated measures of SCC within cow. Results were controlled for farm of origin, stage of lactation, parity, season, and test-day milk yield. Compared with the geometric mean SCC for cows with LS 1 on each farm, cows on farm 3 with LS 2 produced milk with 28,000 fewer somatic cells/mL, and cows with LS 2 on farm 6 produced milk with 30,000 fewer somatic cells/mL at a test day within 10 d. Cows that would have LS 3 six months later produced milk with 16,000 fewer somatic cells/mL compared with the geometric mean SCC for cows that would have LS 1 in 6 mo time. These results illustrate differences in disease dynamics between farms, highlight potential conflict between lameness and mastitis control measures, and emphasize the importance of developing farm-specific estimates of disease costs, and hence, health management plans in clinical practice
Clinical and molecular characterization of HER2 amplified-pancreatic cancer
<p>Background:
Pancreatic cancer is one of the most lethal and molecularly diverse malignancies. Repurposing of therapeutics that target specific molecular mechanisms in different disease types offers potential for rapid improvements in outcome. Although HER2 amplification occurs in pancreatic cancer, it is inadequately characterized to exploit the potential of anti-HER2 therapies.</p>
<p>Methods:
HER2 amplification was detected and further analyzed using multiple genomic sequencing approaches. Standardized reference laboratory assays defined HER2 amplification in a large cohort of patients (n = 469) with pancreatic ductal adenocarcinoma (PDAC).</p>
<p>Results:
An amplified inversion event (1 MB) was identified at the HER2 locus in a patient with PDAC. Using standardized laboratory assays, we established diagnostic criteria for HER2 amplification in PDAC, and observed a prevalence of 2%. Clinically, HER2- amplified PDAC was characterized by a lack of liver metastases, and a preponderance of lung and brain metastases. Excluding breast and gastric cancer, the incidence of HER2-amplified cancers in the USA is >22,000 per annum.</p>
<p>Conclusions:
HER2 amplification occurs in 2% of PDAC, and has distinct features with implications for clinical practice. The molecular heterogeneity of PDAC implies that even an incidence of 2% represents an attractive target for anti-HER2 therapies, as options for PDAC are limited. Recruiting patients based on HER2 amplification, rather than organ of origin, could make trials of anti-HER2 therapies feasible in less common cancer types.</p>
On Relativistic Material Reference Systems
This work closes certain gaps in the literature on material reference systems
in general relativity. It is shown that perfect fluids are a special case of
DeWitt's relativistic elastic media and that the velocity--potential formalism
for perfect fluids can be interpreted as describing a perfect fluid coupled to
a fleet of clocks. A Hamiltonian analysis of the elastic media with clocks is
carried out and the constraints that arise when the system is coupled to
gravity are studied. When the Hamiltonian constraint is resolved with respect
to the clock momentum, the resulting true Hamiltonian is found to be a
functional only of the gravitational variables. The true Hamiltonian is
explicitly displayed when the medium is dust, and is shown to depend on the
detailed construction of the clocks.Comment: 18 pages, ReVTe
The Void Abundance with Non-Gaussian Primordial Perturbations
We use a Press-Schechter-like calculation to study how the abundance of voids
changes in models with non-Gaussian initial conditions. While a positive
skewness increases the cluster abundance, a negative skewness does the same for
the void abundance. We determine the dependence of the void abundance on the
non-Gaussianity parameter fnl for the local-model bispectrum-which approximates
the bispectrum in some multi-field inflation models-and for the equilateral
bispectrum, which approximates the bispectrum in e.g. string-inspired DBI
models of inflation. We show that the void abundance in large-scale-structure
surveys currently being considered should probe values as small as fnl < 10 and
fnl^eq < 30, over distance scales ~10 Mpc.Comment: Submitted to JCA
Entropy function and attractors for AdS black holes
We apply Sen's entropy formalism to the study of the near horizon geometry
and the entropy of asymptotically AdS black holes in gauged supergravities. In
particular, we consider non-supersymmetric electrically charged black holes
with AdS_2 xS^{d-2} horizons in U(1)^4 and U(1)^3 gauged supergravities in d=4
and d=5 dimensions, respectively. We study several cases including
static/rotating, BPS and non-BPS black holes in Einstein as well as in
Gauss-Bonnet gravity. In all examples, the near horizon geometry and black hole
entropy are derived by extremizing the entropy function and are given entirely
in terms of the gauge coupling, the electric charges and the angular momentum
of the black hole.Comment: 27 pages, no figures, references adde
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