On the consistency of de Sitter vacua

In this paper the consistency of the de Sitter invariant $\alpha$-vacua, which have been introduced as simple tools to study the effects of transplanckian physics, is investigated. In particular possible non renormalization problems are discussed, as well as non standard properties of Greens functions. We also discuss the non thermal properties of the $\alpha$-vacua and the necessity of $\alpha$ to change. The conclusion is that non of these problems necessarily exclude an application of the $\alpha$-vacua to inflation.Comment: 12 pages, v2: minor clarifications and corrections to reference

Squeezed States in the de Sitter Vacuum

We discuss the treatment of squeezed states as excitations in the Euclidean vacuum of de Sitter space. A comparison with the treatment of these states as candidate no-particle states, or alpha-vacua, shows important differences already in the free theory. At the interacting level alpha-vacua are inconsistent, but squeezed state excitations seem perfectly acceptable. Indeed, matrix elements can be renormalized in the excited states using precisely the standard local counterterms of the Euclidean vacuum. Implications for inflationary scenarios in cosmology are discussed.Comment: 15 pages, no figures. One new citation in version 3; no other change

On Thermalization in de Sitter Space

We discuss thermalization in de Sitter space and argue, from two different points of view, that the typical time needed for thermalization is of order $R^{3}/l_{pl}^{2}$, where $R$ is the radius of the de Sitter space in question. This time scale gives plenty of room for non-thermal deviations to survive during long periods of inflation. We also speculate in more general terms on the meaning of the time scale for finite quantum systems inside isolated boxes, and comment on the relation to the Poincar\'{e} recurrence time.Comment: 14 pages, 2 figures, latex, references added. Improved discussion in section 3 adde

Origins of the Ambient Solar Wind: Implications for Space Weather

The Sun's outer atmosphere is heated to temperatures of millions of degrees, and solar plasma flows out into interplanetary space at supersonic speeds. This paper reviews our current understanding of these interrelated problems: coronal heating and the acceleration of the ambient solar wind. We also discuss where the community stands in its ability to forecast how variations in the solar wind (i.e., fast and slow wind streams) impact the Earth. Although the last few decades have seen significant progress in observations and modeling, we still do not have a complete understanding of the relevant physical processes, nor do we have a quantitatively precise census of which coronal structures contribute to specific types of solar wind. Fast streams are known to be connected to the central regions of large coronal holes. Slow streams, however, appear to come from a wide range of sources, including streamers, pseudostreamers, coronal loops, active regions, and coronal hole boundaries. Complicating our understanding even more is the fact that processes such as turbulence, stream-stream interactions, and Coulomb collisions can make it difficult to unambiguously map a parcel measured at 1 AU back down to its coronal source. We also review recent progress -- in theoretical modeling, observational data analysis, and forecasting techniques that sit at the interface between data and theory -- that gives us hope that the above problems are indeed solvable.Comment: Accepted for publication in Space Science Reviews. Special issue connected with a 2016 ISSI workshop on "The Scientific Foundations of Space Weather." 44 pages, 9 figure

Ubiquitin and Parkinson's disease through the looking glass of Genetics

Biochemical alterations found in the brains of Parkinson's disease (PD) patients indicate that cellular stress is a major driver of dopaminergic neuronal loss. Oxidative stress, mitochondrial dysfunction, and ER stress lead to impairment of the homeostatic regulation of protein quality control pathways with a consequent increase in protein misfolding and aggregation and failure of the protein degradation machinery. Ubiquitin signalling plays a central role in protein quality control; however, prior to genetic advances, the detailed mechanisms of how impairment in the ubiquitin system was linked to PD remained mysterious. The discovery of mutations in the α-synuclein gene, which encodes the main protein misfolded in PD aggregates, together with mutations in genes encoding ubiquitin regulatory molecules, including PTEN-induced kinase 1 (PINK1), Parkin, and FBX07, has provided an opportunity to dissect out the molecular basis of ubiquitin signalling disruption in PD, and this knowledge will be critical for developing novel therapeutic strategies in PD that target the ubiquitin system

Search for leptophobic Z ' bosons decaying into four-lepton final states in proton-proton collisions at root s=8 TeV

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Search for black holes and other new phenomena in high-multiplicity final states in proton-proton collisions at root s=13 TeV

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Search for heavy resonances decaying into a vector boson and a Higgs boson in final states with charged leptons, neutrinos, and b quarks

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Search for high-mass diphoton resonances in proton-proton collisions at 13 TeV and combination with 8 TeV search

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Measurements of differential production cross sections for a Z boson in association with jets in pp collisions at root s=8 TeV

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