37 research outputs found
Coordinatively Unsaturated T-Shaped Platinum(II) Complexes Stabilized by Small N-Heterocyclic Carbene Ligands. Synthesis and Cyclometalation
Catalytic Approaches for the Direct Heterofunctionalization of Aliphatic Carboxylic Acids and Their Equivalents with Group 16 Elements
Evolution of CâH Bond Functionalization from Methane to Methodology
This Perspective presents the fundamental principles, the elementary reactions, the initial catalytic systems, and the contemporary catalysts that have converted CâH bond functionalization from a curiosity to a reality for synthetic chemists. Many classes of elementary reactions involving transition-metal complexes cleave CâH bonds at typically unreactive positions. These reactions, coupled with a separate or simultaneous functionalization process lead to products containing new CâC, CâN, and CâO bonds. Such reactions were initially studied for the conversion of light alkanes to liquid products, but they have been used (and commercialized in some cases) most often for the synthesis of the more complex structures of natural products, medicinally active compounds, and aromatic materials. Such a change in direction of research in CâH bond functionalization is remarkable because the reactions must occur at an unactivated CâH bond over functional groups that are more reactive than the CâH bond toward classical reagents. The scope of reactions that form CâC bonds or install functionality at an unactivated CâH bond will be presented, and the potential future utility of these reactions will be discussed