Cost-Efficient Bridge Scour Health Monitoring using Commercial Sensors

Bridge scouring has been a major international issue regarding bridge health and the overall longevity of a bridge. A common bridge health concern such as scouring accounts for close to 60% of bridge failures in the United States and is a leading cause to a bridge being in critical condition. Traditional methods to combat this failure is to measure the scour depth to assess a bridge health. Due to safety concerns of the traditional method, this study proposes to monitor a bridge’s health using a vibration-based technique. At present, vibration-based techniques have yet to be utilized reliably in the field. The sensor system chosen for this study is the accelerometers. Acceleration data collected from the sensors can be translated into frequency and amplitudes to monitor bridge health status. A laboratory experiment is conducted within this study with an oscillating platform to simulate expected vibrations that would be seen within the field. Once laboratory verifications were done, the sensor system will be deployed in the field for further observations. Collected data from this study is expected to show distinction between oscillation behavior of a scour critical bridge and non-scour critical bridge when compared to the theoretical natural vibration of a bridge. The laboratory and field collected data from this study will be discussed in the symposium

Development of Methodologies to Reduce the DCAD of Hays for Transition Dairy Cows

Hypocalcemia (clinical and subclinical) create a major economic loss in early postpartum dairy cows. Ration formulation for dairy cows just prior to parturition must control the diet cation-anion difference (DCAD) if hypocalcemia and milk fever are to be avoided. The purpose of this research was to evaluate the use of specific fertilizer regimes for forages and evaluate their impact on mineral and DCAD levels in hays, as well as forage yields. The experimental design involved four different species of hay (alfalfa, bromegrass, orchardgrass, and reed canarygrass) fertilized with either CaCl2 or K2CO3 (designated K2O) alone or a combination (designated KCl) of both. In the plots not receiving K fertilization (Control and CaCl2) the K content of the plants regardless of species was lower relative to those receiving K (K2O and KCl). With regards to plant Cl content, the plots fertilized with CaCl2 alone or in combination with K2O resulted in substantial and at least a 2 fold elevations in tissue chloride in all the hays tested. DCAD was also significantly reduced with CaCl2 treatment alone and was reduced 50-75% in the Orchardgrass, Reed Canarygrass and Orchardgrass hays. The combination of K2O and CaCl2 resulted in an attenuation of this effect. CaCl2 treatment alone had no detrimental effect on yield when compared to Control plots. However, those plots fertilized with K (with or without Cl) had higher numerical yields than those not receiving K. These data suggest that withholding K fertilization in combination with Cl fertilization may be an effective means of increasing the Cl and ultimately decreasing the DCAD content of several species of hay without sacrificing yield. We will continue to monitor the effects of K and Cl fertilization on plant parameters during the FY05 and FY06 growing seasons. The effect of Cl fertilization on hay quality and palatability is currently under investigation

Development of Methodologies to Reduce the DCAD of Hay Forages for Transition Dairy Cows

Ration formulation for dairy cows just prior to parturition must control the dietary cation-anion difference (DCAD) if hypocalcemia and milk fever are to be avoided. One key to reducing hypocalcemia is to avoid incorporation of high-K forages into the ration. The excessive K content of these forages can cause metabolic alkalosis in the cow and subsequently hypocalcemia and milk fever. Alfalfa and other cool-season grasses are often used in dairy rations. Reducing K content of forages can be achieved by restricting K fertilization so that soils do not support luxury consumption. Since K is the major cation contributing to highDCAD diets, an obvious solution is to limit K fertilization of the forage crop to avoid luxury consumption of K. However, some forages may have reduced yield and increased winter kill if K concentrations are less than 2.0%, particularly alfalfa. Thus, producing alfalfa with less than 2% K may not be profitable, especially in northern regions. In addition to decreasing forage K, the producer can also increase the Cl content of the forages, and the resulting DCAD will be more favorable for the late-gestation cows

Regional hydrology of the Dixie Valley geothermal field, Nevada: preliminary interpretations of chemical and isotopic data

Chemical and isotopic analyses of Dixie Valley regional waters indicate several distinct groups ranging in recharge age from Pleistocene (<20 ka) to recent (<50a). Valley groundwater is older than water from perennial springs and artesian wells in adjacent ranges, with Clan Alpine range (east) much younger (most <50a) than Stillwater range (west; most >1000a). Geothermal field fluids ({approximately}12-14 ka) appear derived from water similar in composition to non-thermal groundwater observed today in valley artesian wells (also -14 ka). Geothermal fluid interaction with mafic rocks (Humboldt Lopolith) appears to be common, and significant reaction with granodiorite may also occur. Despite widespread occurrence of carbonate rocks, large scale chemical interaction appears minor. Age asymmetry of the ranges, more extensive interaction with deep-seated waters in the west, and distribution of springs and artesian wells suggest the existence of a regional upward hydrologic gradient with an axis in proximity to the Stillwater range

Myeloperoxidase-dependent oxidation of etoposide in human myeloid progenitor CD34+ cells

ABSTRACT Etoposide is a widely used anticancer drug successfully utilized for treatment of many types of cancer in children and adults. Its use, however, is associated with an increased risk of development of secondary acute myelogenous leukemia (t-AML) involving MLL gene MOL #68718

High-precision Studies of the 3^{\bf{3}}He(e,e′^{\bf{\prime}}p) Reaction at the Quasielastic Peak

Precision studies of the reaction $^{3}$He(e,e$^\prime$p) using the three-spectrometer facility at the Mainz microtron MAMI are presented. All data are for quasielastic kinematics at $|\vec{q} | =685$ MeV/c. Absolute cross sections were measured at three electron kinematics. For the measured missing momenta range from 10 to 165 MeV/c, no strength is observed for missing energies higher than 20 MeV. Distorted momentum distributions were extracted for the two-body breakup and the continuum. The longitudinal and transverse behavior was studied by measuring the cross section for three photon polarizations. The longitudinal and transverse nature of the cross sections is well described by a currently accepted and widely used prescription of the off-shell electron-nucleon cross-section. The results are compared to modern three-body calculations and to previous data.Comment: 4 pages, 3 figures. Submitted for publication in Phys. Rev. Let

A Measurement of the Interference Structure Function, R_LT, for the 12C(e,e'p) reaction in the Quasielastic Region

The coincidence cross-section and the interference structure function, R_LT, were measured for the 12C(e,e'p) 11B reaction at quasielastic kinematics and central momentum transfer of q=400 MeV/c. The measurement was at an opening angle of theta_pq=11 degrees, covering a range in missing energy of E_m = 0 to 65 MeV. The R_LT structure function is found to be consistent with zero for E_m > 50 MeV, confirming an earlier study which indicated that R_L vanishes in this region. The integrated strengths of the p- and s-shell are compared with a Distorted Wave Impulse Approximation calculation. The s-shell strength and shape are compared with a Hartree Fock-Random Phase Approximation calculation. The DWIA calculation overestimates the cross sections for p- and s-shell proton knockout as expected, but surprisingly agrees with the extracted R_LT value for both shells. The HF-RPA calculation describes the data more consistently, which may be due to the inclusion of 2-body currents in this calculation.Comment: 8 Pages LaTex, 5 postscript figures. Submitted to Phys. Rev.

Azetidines Kill Multidrug-Resistant <i>Mycobacterium tuberculosis</i> without Detectable Resistance by Blocking Mycolate Assembly

Tuberculosis (TB) is the leading cause of global morbidity and mortality resulting from infectious disease, with over 10.6 million new cases and 1.4 million deaths in 2021. This global emergency is exacerbated by the emergence of multidrug-resistant MDR-TB and extensively drug-resistant XDR-TB; therefore, new drugs and new drug targets are urgently required. From a whole cell phenotypic screen, a series of azetidines derivatives termed BGAz, which elicit potent bactericidal activity with MIC99 values &lt;10 μM against drug-sensitive Mycobacterium tuberculosis and MDR-TB, were identified. These compounds demonstrate no detectable drug resistance. The mode of action and target deconvolution studies suggest that these compounds inhibit mycobacterial growth by interfering with cell envelope biogenesis, specifically late-stage mycolic acid biosynthesis. Transcriptomic analysis demonstrates that the BGAz compounds tested display a mode of action distinct from the existing mycobacterial cell wall inhibitors. In addition, the compounds tested exhibit toxicological and PK/PD profiles that pave the way for their development as antitubercular chemotherapies. </p

Internet-based interventions for the secondary prevention of coronary heart disease

Background The Internet could provide a means of delivering secondary prevention programmes to people with coronary heart disease (CHD). Objectives To determine the effectiveness of Internet-based interventions targeting lifestyle changes and medicines management for the secondary prevention of CHD. Search methods We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, in December 2014. We also searched six other databases in October 2014, and three trials registers in January 2015 together with reference checking and handsearching to identify additional studies. Selection criteria Randomised controlled trials (RCTs) evaluating Internet-delivered secondary prevention interventions aimed at people with CHD. Data collection and analysis Two review authors independently assessed risk of bias and extracted data according to the Cochrane Handbook for Systematic Reviews of Interventions. We assessed evidence quality using the GRADE approach and presented this in a 'Summary of findings' table

Social Class

Discussion of class structure in fifth-century Athens, historical constitution of theater audiences, and the changes in the comic representation of class antagonism from Aristophanes to Menander