592 research outputs found
Temporal Impacts of Problematic Social Media Content on Perceived Employee Hirability
Job applicantsâ social media postings and presence can impact employersâ perceptions during the hiring process. The current study expands this line of inquiry, exploring the effects of both message characteristics (i.e. post temporality) and individual characteristics (i.e. hiring managerâs view about individualsâ ability to change over time). Results of a 2 (problematic content: present v. absent) Ă 3 (post temporality: recent v. 2 years ago v. 5 years ago) experiment (N = 220) revealed the negative main effect of the presence of problematic social media content was moderated by the temporality of the post: More recent posts more substantively impacted perceptions of person-job fit. This moderation effect was further moderated by the managerâs incrementalism: the belief peopleâs personalities can change over time. Similar patterns of effects were not identified for broader perceptions of the applicantâs general employability
Hormonal regulation of alveolarization: structure-function correlation
BACKGROUND: Dexamethasone (Dex) limits and all-trans-retinoic acid (RA) promotes alveolarization. While structural changes resulting from such hormonal exposures are known, their functional consequences are unclear. METHODS: Neonatal rats were treated with Dex and/or RA during the first two weeks of life or were given RA after previous exposure to Dex. Morphology was assessed by light microscopy and radial alveolar counts. Function was evaluated by plethysmography at d13, pressure volume curves at d30, and exercise swim testing and arterial blood gases at both d15 and d30. RESULTS: Dex-treated animals had simplified lung architecture without secondary septation. Animals given RA alone had smaller, more numerous alveoli. Concomitant treatment with Dex + RA prevented the Dex-induced changes in septation. While the results of exposure to Dex + RA were sustained, the effects of RA alone were reversed two weeks after treatment was stopped. At d13, Dex-treated animals had increased lung volume, respiratory rate, tidal volume, and minute ventilation. On d15, both RA- and Dex-treated animals had hypercarbia and low arterial pH. By d30, the RA-treated animals resolved this respiratory acidosis, but Dex-treated animals continued to demonstrate blood gas and lung volume abnormalities. Concomitant RA treatment improved respiratory acidosis, but failed to normalize Dex-induced changes in pulmonary function and lung volumes. No differences in exercise tolerance were noted at either d15 or d30. RA treatment after the period of alveolarization also corrected the effects of earlier Dex exposure, but the structural changes due to RA alone were again lost two weeks after treatment. CONCLUSION: We conclude that both RA- and corticosteroid-treatments are associated with respiratory acidosis at d15. While RA alone-induced changes in structure andrespiratory function are reversed, Dex-treated animals continue to demonstrate increased respiratory rate, minute ventilation, tidal and total lung volumes at d30. Concomitant treatment with Dex + RA prevents decreased septation induced by Dex alone and results in correction of hypercarbia. However, these animals continue to have abnormal pulmonary function and lung volumes. Increased septation as a result of RA treatment alone is reversed upon discontinuation of treatment. These data suggest that Dex + RA treatment results in improved gas exchange likely secondary to normalized septation
Experimental and computational analyses reveal that environmental restrictions shape HIV-1 spread in 3D cultures
Here, using an integrative experimental and computational approach, Imle et al. show how cell motility and density affect HIV cell-associated transmission in a three-dimensional tissue-like culture system of CD4+ T cells and collagen, and how different collagen matrices restrict infection by cell-free virions
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EFFECTS OF DIFFERENT PARAMETERS ON DED HR-1 ON LOW CYCLE FATIGUE, TENSILE STRENGTH, AND MICROSTRUCTURE
NASA HR1 alloy is an iron-nickel based material designed by NASA and derived from A286
and JBK-75 alloys. At extreme conditions, NASA HR1 possess high strength, high fatigue resistance,
and high resistance to corrosion and hydrogen embrittlement. The main applications include
structural components and liquid rocket engine nozzles with internal cooling channels. NASA has
produced HR1 using vacuum induction melting (VIM), a considerably expensive fabrication method.
Aimed to explore other more affordable and accessible manufacturing methods, HR1 specimens were
fabricated under different parameters using Laser-Powder Directed Energy Deposition (LP-DED) and
were heat treated through stress relief, homogenization, solution treatment and aging. The feasibility
of this AM process was investigated by evaluating mechanical and microstructural analysis on
specimens. This work finalizes with discussion and remarks on tensile and low-cycle fatigue
properties and its relationship with microstructural features.Mechanical Engineerin
Developing logistic software platforms: e-market place, a case study
This paper describes a framework for software development with emphasis on logistics platforms. Specifically, a case study is presented regarding the Logport program in Colombiaâs Caribbean coast. The software development is based on the merging of modeling, design, and agile development techniques aimed towards software production. The agile methodologies discussed herein include Scrum, XP, and Crystal among others, and specific verification and validation aspects of CMMI 1.3 are evaluated. Furthermore, the integration of emerging technologies including elastic computing in cloud computing that allows scaled integration, security, load balancing, process speed, and high concurrency among other features are discussed. Finally, the proposed solutions cover actual and emergent needs in a B2B or B2C electronic commerce dynamic environment where suppliers and clients offer and demand transport, storage, and customs services. In this environment, their goal is to ensure there is added value to their logistics processes starting at the inputs and all the way to the outputs of the commercial business processes. Colombiaâs Caribbean region is one such multimodal and multiport environment in which there is constant demand for low cost, time and storage optimization, and customs reliability for the businesspersons of this region, which serves as a Hub for the American Caribbean
Dynamics of HIV-1 Assembly and Release
Assembly and release of human immunodeficiency virus (HIV) occur at the plasma membrane of infected cells and are driven by the Gag polyprotein. Previous studies analyzed viral morphogenesis using biochemical methods and static images, while dynamic and kinetic information has been lacking until very recently. Using a combination of wide-field and total internal reflection fluorescence microscopy, we have investigated the assembly and release of fluorescently labeled HIV-1 at the plasma membrane of living cells with high time resolution. Gag assembled into discrete clusters corresponding to single virions. Formation of multiple particles from the same site was rarely observed. Using a photoconvertible fluorescent protein fused to Gag, we determined that assembly was nucleated preferentially by Gag molecules that had recently attached to the plasma membrane or arrived directly from the cytosol. Both membrane-bound and cytosol derived Gag polyproteins contributed to the growing bud. After their initial appearance, assembly sites accumulated at the plasma membrane of individual cells over 1â2 hours. Assembly kinetics were rapid: the number of Gag molecules at a budding site increased, following a saturating exponential with a rate constant of âź5Ă10â3 sâ1, corresponding to 8â9 min for 90% completion of assembly for a single virion. Release of extracellular particles was observed at âź1,500Âą700 s after the onset of assembly. The ability of the virus to recruit components of the cellular ESCRT machinery or to undergo proteolytic maturation, or the absence of Vpu did not significantly alter the assembly kinetics
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