Map of Impact of Natural Hazards

This paper investigates the mapping of the impact of natural hazards as included in several databases reviewed or created by the author. These are: - The database of the contribution of the session series “Natural hazards’ impact on urban areas and infrastructure”, convened and co-convened by the first author over 15 years at the European Geosciences General Assembly. - A database created from reviews of students supervised by the authors in frame of the course “Protection of settlements against risks” at the home university. - A collection of historical photographs from the 19th century on different natural and man-made hazards from the Canadian Centre for Architecture, the archive review of which has been performed by the first author and which will be subject of a book to be published about the time of the conference. -Two reviewed collections, one from the exhibition and book on “Images of disasters” (German research) and one on the book “Illustrated history of natural disasters” which include major disasters from the beginning of the mankind. In frame of the paper maps of the spread of data will be presented, created using both arcGIS online and GoogleMaps (see https://www.google.com/maps/d/edit?mid=zpbbz3WgVMBs.k-3vhGj- -l1M&usp=sharing), comparing the source and the type of hazard, to see eventual overlappings between the databases

Repair of a wide sternal cleft in a young female

AbstractSternal clefts are rare congenital malformations of the anterior chest wall. Surgical correction is typically recommended as early as possible due to the compliance and growth potential of the infant sternum. Several operative techniques have been employed with great success. However, there is a paucity of data regarding repair in large clefts refractory to standard reparative techniques. We report the successful surgical repair in a 15-month-old female with an excessively large, superior sternal cleft

A malignant omental extra-gastrointestinal stromal tumor on a young man: a case report and review of the literature

<p>Abstract</p> <p>Background</p> <p>Gastrointestinal stromal tumors (GIST) are uncommon intra-abdominal tumors. These tumors tend to present with higher frequency in the stomach and small bowel. In fewer than 5% of cases, they originate primarily from the mesentery, omentum, or peritoneum. Furthermore, these extra-gastrointestinal tumors (EGIST) tend to be more common in patients greater than 50 years of age. Rarely do EGIST tumors present in those younger than 40 years of age.</p> <p>Case presentation</p> <p>We report a case of a large EGIST in a 27-year-old male. An abdominal pelvic computerized tomography imaging demonstrated an intra-abdominal mass of 22 cm, without invasion of adjacent viscera or liver lesions. This mass was resected <it>en bloc </it>with its fused omentum and an adherent portion of sigmoid colon. Pathology results demonstrated a malignant gastrointestinal stromal tumor with positive CD117 (c-kit) staining, and negative margins of resection, and no continuity of tumor with the sigmoid colon. Due to the malignant and aggressive nature of this patient's tumor, he was started on STI-571 as adjuvant chemotherapy.</p> <p>Conclusion</p> <p>Stromal tumors of an extra-gastrointestinal origin are rare. Of the reported omental and mesenteric EGISTs in four published series, a total of 99 tumors were studied. Of the 99 patients in these series only 8 were under 40 years of age, none were younger than 30 years old; and only 5 were younger than 35 years old. Our patient's age is at the lower end of the age spectrum for the reported EGISTs. Young patients who present with an extra-gastrointestinal stromal tumor (EGIST), who have complete resection with negative margins, have a good prognosis. There is little data to support the role of STI-571 in adjuvant or neoadjuvant therapy after curative resection. Given the lack of data, the use of STI-571 must be individualized.</p

PhD

dissertationEssential hypertension is an important cause of human cardiovascular morbidity and mortality in most developed countries. Analysis of hypertensive siblings has revealed significant genetic linkage and alleilic association between angiotensinogen, the precursor of angiotensin II, and essential hypertension. Angiotensinogen is one of the components of the renin-angiotensin system that plays a central role in blood pressure regulation. Beside the circulating system, multiple tissue renin-angiotensin system including in arterial wall, heart, brain, and kidney have been described. Transgenic models confirmed a direct, causal relationship between increased angiotensinogen gene copy number and increased arterial pressure. Nevertheless, the site of action of angiotensinogen overexpression on increased pressure remains only speculative. We proposed to identify the role that individual renin-angiotensin systems have on the hypertensive phenotype by creating animal models with altered tissue-specific angiotensinogen expression. Furthermore, for a better understanding of the renal system, we will investigate the regulation and its interaction with other systems involved in blood pressure homeostatsis

Cutaneous metastasis as a first sign of adenocarcinoma of the cervix

Cervical cancer remains one of the most common malignancies diagnosed in women as well as a leading cause of cancer related deaths in women worldwide. Cutaneous metastasis associated with cervical malignancy is a remarkably rare phenomenon. We present a patient whose cutaneous signs led to the diagnosis of metastatic adenocarcinoma of the cervix

Cherubism in a 4-year-old boy managed with tumor curettage, mandibular osteotomies and repositioning

Cherubism is a rare disease characterized by significant loss of medullary bone which is replaced by excessive amounts of fibrous tissue growth within the mandible and maxilla. We present a case of a 4-year-old boy with a rapidly enlarging mandible and maxilla, causing significant change in the facial contour, malocclusion and phonation difficulties. He was treated with aggressive tumor curettage, lateral mandibular cortex osteotomies with medial repositioning. This allowed obliteration of the enlarged medullary space and restoration of the normal mandibular anatomy. At 12 months postoperatively, the patient had significant improvement in facial contour, normal outward appearance, and stable dentition

Successful reconstruction of bilateral oral commissure fusion secondary to Stevens Johnson syndrome

Stevens Johnson syndrome (SJS) is a rare and often fatal hypersensitivity reaction commonly triggered by drugs which results in the uncontrolled destruction of keratinocytes with both cutaneous and mucosal involvement. Fusion of the oral commissures, although reported in burn victims, is a very uncommon complication of SJS. The successful reconstruction of oral commissures fusion using a modified commissuroplasty technique in a 19-year-old Hispanic female with severe microstomia secondary to SJS is presented here. Re-establishment of normal speech, oral intake, as well as aesthetic appearance were achieved