Minimal dataset for study.

(XLS)</p

Antibody measurements.

(DOCX)</p

Characteristics of study participants¹.

Characteristics of study participants1.</p

The association between packs per day (ppd) smoked and antibodies to Epstein Barr Virus nuclear antigen (EBV NA), virion (EBV virion), and anti-viral capsid antigen (EBV VCA) from linear regression models employing age, sex, race, and psychiatric diagnosis as covariates.

(CMV- F(9, 1299) = 28.01, R2 = 0.1314, VIF = 1.28; EBV NA - F(9, 1299) = 16.97, R2 = 0.1052. VIF = 1.28; EBV Virion – F (9,1269) = 31.71, R2 = 0.1836, VIF = 1.28; EBV VCA F(9,1280) = 29.82, R2 = 0.1733, VIF = 1.28).</p

The association between cigarette smoking and quantitative levels of antibodies to Cytomegalovirus (CMV); Epstein Barr Virus nuclear antigen (EBV NA), virion (EBV virion), and anti-viral capsid antigen (EBV VCA); Herpes Simplex Virus Type 1 (HSV-1); Varicella Zoster Virus (VZV); and Human Herpes Virus 6 (HHV-6) from linear regression models employing age, sex, race, and psychiatric diagnosis as covariates; ** = p<.01, *** p<.001).

N = 1323 except for HHV-6, N = 1206. (CMV- F(7, 1315) = 28.01, R2 = 0,1298, VIF = 1.32; EBV NA - F(7, 1315) = 21,82, R2 = 0,1041, VIF = 1.32; EBV Virion – F (7,1284) = 40.59, R2 = 0.1812, VIF = 1.32; EBV VCA F(7,1296) = 37.96, R2 = 0.1701, VIF = 1.32; HSV-1- F(7, 1315) = 11.35, R2 = 0.0570, VIF = 1.32; VZV – F(7, 1300) = 5.04, R2 = 0.0264, VIF = 1.31); HHV-6 – F(7,1198), R = 0.0182, VIF = 1.29).</p

Cigarette smoking status and packs per day smoked by diagnostic group.

Cigarette smoking status and packs per day smoked by diagnostic group.</p

Marginal effects (mean +/- 95% confidence intervals of the indicated EBV antibody by number of cigarettes smoked per day adjusted for age, gender, race, and diagnostic group.

Marginal effects (mean +/- 95% confidence intervals of the indicated EBV antibody by number of cigarettes smoked per day adjusted for age, gender, race, and diagnostic group.</p