Synthesis of functionalized small alpha-trifluoroethyl amine scaffolds via Grignard addition to N-aryl hemiaminal ethers

The synthesis of a variety of small alpha-branched trifluoroethyl amines was achieved by reaction of N-aryl hemiaminal ethers with organomagnesium reagents

Synthesis of functionalized small alpha-trifluoroethyl amine scaffolds via Grignard addition to N-aryl hemiaminal ethers

The synthesis of a variety of small alpha-branched trifluoroethyl amines was achieved by reaction of N-aryl hemiaminal ethers with organomagnesium reagents

Threshold or Limit? Precipitation Dependency of Austrian Landslides, an Ongoing Challenge for Hazard Mapping under Climate Change

Climate change is set to increase landslide frequency around the globe, thus increasing the potential exposure of people and material assets to these disturbances. Landslide hazard is commonly modelled from terrain and precipitation parameters, assuming that shorter, more intense rain events require less precipitation volume to trigger a slide. Given the extent of non-catastrophic slides, an operable vulnerability mapping requires high spatial resolution. We combined heterogeneous regional slide inventories with long-term meteorological records and small-scale spatial information for hazard modelling. Slope, its (protective) interaction with forest cover, and altitude were the most influential terrain parameters. A widely used exponential threshold to estimate critical precipitation was found to incorrectly predict meteorological hazard to a substantial degree and, qualitatively, delineate the upper boundary of natural conditions rather than a critical threshold. Scaling rainfall parameters from absolute values into local probabilities (per km²) however revealed a consistent pattern across datasets, with the transition from normal to critical rain volumes and durations being gradual rather than abrupt thresholds. Scaled values could be reverted into site-specific nomograms for easy appraisal of critical rain conditions by local stakeholders. An overlay of terrain-related hazard with infrastructure yielded local vulnerability maps, which were verified with actual slide occurrence. Multiple potential for observation bias in ground-based slide reporting underlined the value of complementary earth observation data for slide mapping and early warning

How little pain and disability do patients with low back pain have to experience to feel that they have recovered?

Epidemiological and clinical studies of people with low back pain (LBP) commonly measure the incidence of recovery. The pain numerical rating scale (NRS), scores from 0 to 10, and Roland Morris disability questionnaire (RMDQ), scores from 0 to 24, are two instruments often used to define recovery. On both scales higher scores indicate greater severity. There is no consensus, however, on the cutoff scores on these scales that classify people as having recovered. The aim of this study was to determine which cutoff scores most accurately classify those who had recovered from LBP. Subjects from four clinical studies were categorized as ‘recovered’ or ‘unrecovered’ according to their self-rating on a global perceived effect scale. Odd ratios were calculated for scores of 0, 1, 2, 3 and 4 on the NRS and RMDQ to predict perceived recovery. Scores of 0 on the NRS and ≤2 on the RMDQ most accurately identify patients who consider themselves completely recovered. The diagnostic odds ratio (OR) for predicting recovery was 43.9 for a score of 0 on the NRS and 17.6 for a score of ≤2 on the RMDQ. There was no apparent effect of LBP duration or length of follow-up period on the optimal cutoff score. OR for the NRS were generally higher than those for RMDQ. Cutoffs of 0 on the NRS and 2 on the RMDQ most accurately classify subjects as recovered from LBP. Subjects consider pain more than disability when determining their recovery status