Monitoring Composites under Bending Tests with Infrared Thermography

The attention of the present paper is focused on the use of an infrared imaging device to monitor the thermal response of composite materials under cyclic bending. Three types of composites are considered including an epoxy matrix reinforced with either carbon fibres (CFRP) or glass fibres (GFRP) and a hybrid composite involving glass fibres and aluminium layers (FRML). The specimen surface, under bending, displays temperature variations pursuing the load variations with cooling down under tension and warming up under compression; such temperature variations are in agreement with the bending moment. It has been observed that the amplitude of temperature variations over the specimen surface depends on the material characteristics. In particular, the presence of a defect inside the material affects the temperature distribution with deviation from the usual bending moment trend

Porosity Distribution in Composite Structures with Infrared Thermography

Composite structures are increasingly used in the transport industry especially in the aeronautical sector thanks to their favorable strength-to-weight ratio with respect to metals. However, this is true if the final part is defects free and complies with quality requirements. A main weakness in composites is porosity, which is likely to be introduced during manufacturing processes and which may knock down the material characteristics affecting its performance in service. Porosity plays a key role in sandwich structures, which involve novel metal foams as core, since the foam performance strongly depends on size and distribution of pores. The determination of porosity is mostly attained by destructive methods, which supply only a general indication linked to the production part number. Conversely, composites may entail local significant variation of porosity, which may be discovered only with effective nondestructive techniques. The attention of the present work is focused on the possibility to use infrared thermography to get information about the amount and distribution of porosity. In particular, two techniques: flash thermography and lock-in thermography are used to comply with requirements of both monolithic composites and metal foams

Visualization of Thermal Effects in Polypropylene-based Composites under Cyclic Bending Tests☆

Abstract The attention of this paper is focused on surface temperature changes which are experienced by thermoplastic composite materials under cyclic bending tests. Such changes are visualized and measured with an infrared imaging device and later analyzed to gain information which, coupled with other mechanical and/or chemical properties, may be exploited for the material characterization. In particular, thermoplastic composites based on a polypropylene matrix, which may be neat, or modified by the addition of a relatively low amount of a specific compatibilizing agent, and reinforced with glass or jute woven fibres are investigated

A randomized phase 3 study on the optimization of the combination of bevacizumab with FOLFOX/OXXEL in the treatment of patients with metastatic colorectal cancer-OBELICS (Optimization of BEvacizumab scheduLIng within Chemotherapy Scheme).

BACKGROUND: Despite the improvements in diagnosis and treatment, colorectal cancer (CRC) is the second cause of cancer deaths in both sexes. Therefore, research in this field remains of great interest. The approval of bevacizumab, a humanized anti-vascular endothelial growth factor (VEGF) monoclonal antibody, in combination with a fluoropyrimidine-based chemotherapy in the treatment of metastatic CRC has changed the oncology practice in this disease. However, the efficacy of bevacizumab-based treatment, has thus far been rather modest. Efforts are ongoing to understand the better way to combine bevacizumab and chemotherapy, and to identify valid predictive biomarkers of benefit to avoid unnecessary and costly therapy to nonresponder patients. The BRANCH study in high-risk locally advanced rectal cancer patients showed that varying bevacizumab schedule may impact on the feasibility and efficacy of chemo-radiotherapy. METHODS/DESIGN: OBELICS is a multicentre, open-label, randomised phase 3 trial comparing in mCRC patients two treatment arms (1:1): standard concomitant administration of bevacizumab with chemotherapy (mFOLFOX/OXXEL regimen) vs experimental sequential bevacizumab given 4 days before chemotherapy, as first or second treatment line. Primary end point is the objective response rate (ORR) measured according to RECIST criteria. A sample size of 230 patients was calculated allowing reliable assessment in all plausible first-second line case-mix conditions, with a 80% statistical power and 2-sided alpha error of 0.05. Secondary endpoints are progression free-survival (PFS), overall survival (OS), toxicity and quality of life. The evaluation of the potential predictive role of several circulating biomarkers (circulating endothelial cells and progenitors, VEGF and VEGF-R SNPs, cytokines, microRNAs, free circulating DNA) as well as the value of the early [(18)F]-Fluorodeoxyglucose positron emission tomography (FDG-PET) response, are the objectives of the traslational project. DISCUSSION: Overall this study could optimize bevacizumab scheduling in combination with chemotherapy in mCRC patients. Moreover, correlative studies could improve the knowledge of the mechanisms by which bevacizumab enhance chemotherapy effect and could identify early predictors of response. EudraCT Number: 2011-004997-27 TRIAL REGISTRATION: ClinicalTrials.gove number, NCT01718873

Some Particular Aspects of Convective Heat Transfer in Gas Turbines

CD-Rom Proc. Paper no. 4