Oncometabolites: tailoring our genes

Increased glucose metabolism in cancer cells is a phenomenon that has been known for over 90 years, allowing maximal cell growth through faster ATP production and redistribution of carbons towards nucleotide, protein and fatty acid synthesis. Recently, metabolites that can promote tumorigeneis by altering the epigenome have been identified. These ‘oncometabolites’ include the tricarboxylic acid cycle metabolites succinate and fumarate, whose levels are elevated in rare tumours with succinate dehydrogenase and fumarate hydratase mutations, respectively. 2-Hydroxyglutarate is another oncometabolite; it is produced de novo as a result of the mutation of isocitrate dehydrogenase, and is commonly found in gliomas and acute myeloid leukaemia. Interestingly, the structural similarity of these oncometabolites to their precursor metabolite, α-ketoglutarate, explains the tumorigenic potential of these metabolites, by competitive inhibition of a superfamily of enzymes called the α-ketoglutarate-dependent dioxygenases. These enzymes utilize α-ketoglutarate as a cosubstrate, and are involved in fatty acid metabolism, oxygen sensing, collagen biosynthesis, and modulation of the epigenome. They include enzymes that are involved in regulating gene expression via DNA and histone tail demethylation. In this review, we will focus on the link between metabolism and epigenetics, and how we may target oncometabolite-induced tumorigenesis in the future

AIM Research Intersection: Instrument for traffic detection and behavior assessment for a complex urban intersection

The Research Intersection as part of Test field AIM (Application Platform for Intelligent Mobility) is a field instrument for detection and assessment of traffic behavior for a complex urban intersection in the city of Braunschweig, Germany. It serves as tool for the purpose of analyzing natural traffic behavior and phenomena, e.g. in safety related traffic situations, based on empirically observed trajectories. Thus, the facility can be used for a number of applications in the field of intelligent mobility services

Evaluating Commonwealth Coordinated Care: The Experiences of Individuals Dually Eligible for Medicare and Medicaid

Objectives 1. To understand Virginia’s rationale for implementing the Commonwealth Coordinated Care Program and its approach to evaluating it. 2. To provide a framework for examining the health care experiences of individuals with behavioral health and/or long-term service and support needs who are enrolled in the Commonwealth Coordinated Care Program. 3. To inform policy on future options for improving the quality and health care experiences of similar groups of individuals in Virginia and other states

Residual feedback suppression with extended model-based postfilters

When designing closed-loop electro-acoustic systems, which can commonly be found in hearing aids or public address systems, the most challenging task is canceling and/or suppressing the feedback caused by the acoustic coupling of the transducers of such systems. In many applications, feedback cancelation based on adaptive filters is used for this purpose. However, due to computational complexity such a feedback canceler is often limited in the length of the filter’s impulse response. Consequently, a residual feedback, which is still audible and may lead to system instability, remains in most cases. In this work, we present enhancements for model-based postfilters based on a priori knowledge of the feedback path which can be used cooperatively with the adaptive filter-based feedback cancelation system to suppress residual feedback and improve the overall feedback reduction capability. For this, we adapted an existing reverberation model such that our model additionally considers the presence and the performance of the adaptive filter. We tested the effectiveness of our approach by means of both objective and subjective evaluations

Cooper Pair Formation in U(1) Gauge Theory of High Temperature Superconductivity

We study the two-dimensional spin-charge separated Ginzburg-Landau theory containing U(1) gauge interactions as a semi-phenomenological model describing fluctuating condensates in high temperature superconductivity. Transforming the original GL action, we abstract the effective action of Cooper pair. Especially, we clarify how Cooper pair correlation evolves in the normal state from the point of view of spin-charge separation. Furthermore, we point out how Cooper pair couples to gauge field in a gauge-invariant way, stressing the insensitivity of Cooper pair to infrared gauge field fluctuation.Comment: 4 pages, 5 figures included, submitted to J. Phys. Soc. Jp