Hydroxychloroquine in a G6PD-Deficient Patient with COVID-19 Complicated by Haemolytic Anaemia: Culprit or Innocent Bystander?

Hydroxychloroquine has been used worldwide as a first-line treatment for patients hospitalized with COVID-19. Little is known about COVID-19 and its effects on patients with congenital red blood cell disorders. We report a case of haemolytic anaemia in a 32-year-old patient and a fortuitous highlighting of G6PD deficiency. We reviewed the literature to assess the risk of hydroxychloroquine use in this context

Meningioma under progestin treatment, what attitude to adopt?

peer reviewe

Detection of Wolbachia in the Tick Ixodes ricinus is Due to the Presence of the Hymenoptera Endoparasitoid Ixodiphagus hookeri

The identification of micro-organisms carried by ticks is an important issue for human and animal health. In addition to their role as pathogen vectors, ticks are also the hosts for symbiotic bacteria whose impact on tick biology is poorly known. Among these, the bacterium Wolbachia pipientis has already been reported associated with Ixodes ricinus and other tick species. However, the origins of Wolbachia in ticks and their consequences on tick biology (known to be very diverse in invertebrates, ranging from nutritional symbionts in nematodes to reproductive manipulators in insects) are unknown. Here we report that the endoparasitoid wasp Ixodiphagus hookeri (Hymenoptera, Chalcidoidea, Encyrtidae) – strictly associated with ticks for their development - is infested at almost 100% prevalence by a W. pipientis strain belonging to a Wolbachia supergroup that has already been reported as associated with other hymenopteran parasitoids. In a natural population of I. ricinus that suffers high parasitism rates due to I. hookeri, we used specific PCR primers for both hymenopteran and W. pipientis gene fragments to show that all unfed tick nymphs parasitized by I. hookeri also harbored Wolbachia, while unparasitized ticks were Wolbachia-free. We demonstrated experimentally that unfed nymphs obtained from larvae exposed to I. hookeri while gorging on their vertebrate host also harbor Wolbachia. We hypothesize that previous studies that have reported W. pipientis in ticks are due to the cryptic presence of the endoparasitoid wasp I. hookeri. This association has remained hidden until now because parasitoids within ticks cannot be detected until engorgement of the nymphs brings the wasp eggs out of diapause. Finally, we discuss the consequences of this finding for our understanding of the tick microbiome, and their possible role in horizontal gene transfer among pathogenic and symbiotic bacteria

Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): a secondary analysis of the WAPM study on COVID-19.

Objectives To evaluate the strength of association between maternal and pregnancy characteristics and the risk of adverse perinatal outcomes in pregnancies with laboratory confirmed COVID-19. Methods Secondary analysis of a multinational, cohort study on all consecutive pregnant women with laboratory-confirmed COVID-19 from February 1, 2020 to April 30, 2020 from 73 centers from 22 different countries. A confirmed case of COVID-19 was defined as a positive result on real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay of nasal and pharyngeal swab specimens. The primary outcome was a composite adverse fetal outcome, defined as the presence of either abortion (pregnancy loss before 22 weeks of gestations), stillbirth (intrauterine fetal death after 22 weeks of gestation), neonatal death (death of a live-born infant within the first 28 days of life), and perinatal death (either stillbirth or neonatal death). Logistic regression analysis was performed to evaluate parameters independently associated with the primary outcome. Logistic regression was reported as odds ratio (OR) with 95% confidence interval (CI). Results Mean gestational age at diagnosis was 30.6+/-9.5 weeks, with 8.0% of women being diagnosed in the first, 22.2% in the second and 69.8% in the third trimester of pregnancy. There were six miscarriage (2.3%), six intrauterine device (IUD) (2.3) and 5 (2.0%) neonatal deaths, with an overall rate of perinatal death of 4.2% (11/265), thus resulting into 17 cases experiencing and 226 not experiencing composite adverse fetal outcome. Neither stillbirths nor neonatal deaths had congenital anomalies found at antenatal or postnatal evaluation. Furthermore, none of the cases experiencing IUD had signs of impending demise at arterial or venous Doppler. Neonatal deaths were all considered as prematurity-related adverse events. Of the 250 live-born neonates, one (0.4%) was found positive at RT-PCR pharyngeal swabs performed after delivery. The mother was tested positive during the third trimester of pregnancy. The newborn was asymptomatic and had negative RT-PCR test after 14 days of life. At logistic regression analysis, gestational age at diagnosis (OR: 0.85, 95% CI 0.8-0.9 per week increase; pPeer reviewe

Le fer dans tous ses états

Iron is an essential trace metal whose extracellular concentration and stores are efficiently regulated. Systemic iron homeostasis assures a stable milieu in which each cell regulates its iron uptake to meet its own requirements. The system is challenged by variable availability of iron in the diet, by occasional iron losses through bleeding and by the fluctuations in the iron request by iron requiring processes such as erythropoiesis, growth, pregnancy and lactation ;but also by pathologic processes involving aberrant iron retention leading to tissue iron overload and finally to end organ damage. A low serum ferritin is 100 % specific for iron deficiency ;conversely hyperferritinemia is not a reliable sign of iron overload. Iron deficiency is a pan-ethnic disorder more prevalent in western and ageing people. Anemia represents the end stage of iron deficiency. During inflammatory states, iron becomes unavailable for erythropoiesis although adequate stores are present. This phenomenon is called functional iron deficiency and is characteristic of anemia of chronic disorders. Hyperferritinemia may exist in the presence or in the absence of iron overload. A cut off value of > 45 % for transferrine saturation has been suggested to discriminate both settings. All the acquired conditions associated with hyperferritinemia must be excluded before performing genetic testing. Perfect understanding of iron homeostasis regulation as well as an adequate use of analyses exploring iron metabolism are mandatory for proper clinical management of iron deficiency and overload states.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Étude comparative et sémantique de quatre verbes espagnols et français (saber-conocer et savoir-connaître)

Ce travail consiste en une étude comparative et sémantique de deux groupes de verbes : saber et conocer en espagnol, savoir et connaître en français. On se propose de déterminer quels sont les traits sémantiques qui permettent de distinguer saber de conocer en espagnol, et savoir de connaître en français. Cette différence repose essentiellement sur l opposition entre l ancrage spatio-temporel et le non ancrage spatio-temporel du procès auquel ils réfèrent. Cette thèse vise à montrer que cette distinction repose :1) sur l opération mentale qu ils véhiculent : présupposition ou non présupposition d une situation d expérience.2) sur le mode d identification du référent de leur complément : par voie de désignation ou par voie de catégorisation .3) sur la nature du référent : celui-ci renvoie dans un cas à un objet ou à une situation du monde spatio-temporel, dans l autre à un simple fait non ancré dans le monde spatio-temporel.This dissertation is a contrastive and semantic study of the verbs saber/conocer in Spanish and savoir/connaître in French. The purpose of this work is to demonstrate how saber can be distinguished from conocer in Spanish, and savoir from connaître in French. Through a lexical and syntactic study, my aim was to determine whether there was a way of representing a mental operation which could be common to the two languages whenever one uses these verbs. The distinction between these two series of verbs is based on: 1) the mental operation that they entail: in the case of conocer and connaître, previous experience is presupposed, which isn t the case for saber and savoir; 2) the identification of the object referred to: in one case it is done through designation and in the other through categorization ( referential vs attributive use); 3) the nature of the object referred to: in the case of conocer and connaître, the object referred to is identified within space and time, which is not the case with saber and savoir.PARIS3-BU (751052102) / SudocSudocFranceF

Is Raltegravir Indicated in the Treatment of HIV Associated Refractory Immune Thrombocytopenia? A Case Report

info:eu-repo/semantics/nonPublishe

A biomimetic synthesis of coelenterazine analogs

N-(Trifluoroacetyl)dehydrodipeptides 2–3 were coupled to aminomethylene dimethylacetal derivatives 4–5. The resulting pseudo-tripeptides 6 were stepwise deprotected (carbonyl function (7) then amine function) and in situ cyclized into imidazolopyrazines 1

La cardiomyopathie du péripartum

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Villes connectées : détection du risque biologique

International audienceLa sécurité dans les villes est un enjeu majeur dans les pays européens. Le projet IMPETUS vise à développer une plateforme numérique pour améliorer la gestion des évènements.Parmi les outils disponibles, il apparait des manques pour la sécurisation. Un outil pour détecter une attaque biologique est proposé. Il fonctionne en continu et analyse de manière régulière la concentration en bactéries dans l’air. Il permet d’alerter lorsqu’une concentration mesurée présente une valeur supérieure à un seuil. Suite à cette alerte, une phase d’identification de l’organisme sera entreprise. Les campagnes d’essais réalisées dans 3 villes ont permis de montrer une différence entre le contenu microbien de l’air dans des salles vides, des salles avec des activités classiques et des salles avec une simulation d’attaque biologique