2,853 research outputs found
A computational proof of locality in entanglement
In this paper the design and proof of concept (POC) coding of a local hidden
variables computer model is presented. The program violates the Clauser, Horne,
Shimony and Holt inequality CHSH . In our numerical experiment,
we find with our local computer program, CHSH
Random Numbers Certified by Bell's Theorem
Randomness is a fundamental feature in nature and a valuable resource for
applications ranging from cryptography and gambling to numerical simulation of
physical and biological systems. Random numbers, however, are difficult to
characterize mathematically, and their generation must rely on an unpredictable
physical process. Inaccuracies in the theoretical modelling of such processes
or failures of the devices, possibly due to adversarial attacks, limit the
reliability of random number generators in ways that are difficult to control
and detect. Here, inspired by earlier work on nonlocality based and device
independent quantum information processing, we show that the nonlocal
correlations of entangled quantum particles can be used to certify the presence
of genuine randomness. It is thereby possible to design of a new type of
cryptographically secure random number generator which does not require any
assumption on the internal working of the devices. This strong form of
randomness generation is impossible classically and possible in quantum systems
only if certified by a Bell inequality violation. We carry out a
proof-of-concept demonstration of this proposal in a system of two entangled
atoms separated by approximately 1 meter. The observed Bell inequality
violation, featuring near-perfect detection efficiency, guarantees that 42 new
random numbers are generated with 99% confidence. Our results lay the
groundwork for future device-independent quantum information experiments and
for addressing fundamental issues raised by the intrinsic randomness of quantum
theory.Comment: 10 pages, 3 figures, 16 page appendix. Version as close as possible
to the published version following the terms of the journa
Why do Particle Clouds Generate Electric Charges?
Grains in desert sandstorms spontaneously generate strong electrical charges;
likewise volcanic dust plumes produce spectacular lightning displays. Charged
particle clouds also cause devastating explosions in food, drug and coal
processing industries. Despite the wide-ranging importance of granular charging
in both nature and industry, even the simplest aspects of its causes remain
elusive, because it is difficult to understand how inert grains in contact with
little more than other inert grains can generate the large charges observed.
Here, we present a simple yet predictive explanation for the charging of
granular materials in collisional flows. We argue from very basic
considerations that charge transfer can be expected in collisions of identical
dielectric grains in the presence of an electric field, and we confirm the
model's predictions using discrete-element simulations and a tabletop granular
experiment
An exploratory study looking at the relationship marketing techniques used in the music festival industry
There are current issues and trends in the music festival
market, which may affect the success of an event, and market saturation
is at the forefront of these issues. Previous literature, maintaining
the need for a marketing approach to festivals, identifi es the need
for maintaining strong stakeholder relationships in order to succeed
in a business environment; attention has been focused to the theory
of relationship marketing (RM) because of the recognition that this
practice is complementary to the marketing of festivals. The very nature
of the music festival as an annual, usually, 4-day event means that
effective marketing is needed to keep connections with the consumer
throughout the year. This article focuses on the RM techniques
utilised within the music festival industry from the viewpoint of the
festival organiser in an attempt to establish how festival organisations
value and monitor organisational relationships. This article explores
the extent to which these relationships are valued and managed;
furthermore, the variations between these intricate relationships
are considered by focusing on those held with the organisation ’ s
consumers and sponsors, the results of which have provided the
ability to establish the importance and relevance of RM to the industry
and further identify the marketing communication methods employed
to establish and maintain such relationships. In-depth, convergent
interviews have been conducted with a segment of music festival
organisers from a range of events. The results have been integrated
with the study of current literature to best exemplify these issues. It
has been established that RM has a strong role in today ’ s commercial
and independent music festival industry; technological advances are
enabling the organiser to support online relationships further and
increase consumer loyalty. There is a need to expand the research
further because of the complexity of organisational relationships and
the varying categories of festivals
Reproductive Phase Locking of Mosquito Populations in Response to Rainfall Frequency
The frequency of moderate to heavy rainfall events is projected to change in response to global warming. Here we show that these hydrologic changes may have a profound effect on mosquito population dynamics and rates of mosquito-borne disease transmission. We develop a simple model, which treats the mosquito reproductive cycle as a phase oscillator that responds to rainfall frequency forcing. This model reproduces observed mosquito population dynamics and indicates that mosquito-borne disease transmission can be sensitive to rainfall frequency. These findings indicate that changes to the hydrologic cycle, in particular the frequency of moderate to heavy rainfall events, could have a profound effect on the transmission rates of some mosquito-borne diseases
Antipsychotic dose escalation as a trigger for Neuroleptic Malignant Syndrome (NMS): literature review and case series report
Background: “Neuroleptic malignant syndrome” (NMS) is a potentially fatal idiosyncratic reaction to any medication which affects the central dopaminergic system. Between 0.5% and 1% of patients exposed to antipsychotics develop the condition. Mortality rates may be as high as 55% and many risk factors have been reported. Although rapid escalation of antipsychotic dose is thought to be an important risk factor, to date it has not been the focus of a published case series or scientifically defined.
<p/>Aims: To identify cases of NMS and review risk factors for its development with a particular focus on rapid dose escalation in the 30 days prior to onset.
<p/>Methodology: A review of the literature on rapid dose escalation was undertaken and a pragmatic definition of “rapid dose escalation” was made. NMS cases were defined using DSM-IV criteria and systematically identified within a secondary care mental health service. A ratio of titration rate was calculated for each NMS patient and “rapid escalators” and “non rapid escalators” were compared.
<p/>Results: 13 cases of NMS were identified. A progressive mean dose increase 15 days prior to the confirmed episode of NMS was observed (241.7mg/day during days 1-15 to 346.9mg/day during days 16-30) and the mean ratio of dose escalation for NMS patients was 1.4. Rapid dose escalation was seen in 5/13 cases and non rapid escalators had markedly higher daily cumulative antipsychotic dose compared to rapid escalators.
<p/>Conclusions: Rapid dose escalation occurred in less than half of this case series (n=5, 38.5%), although there is currently no consensus on the precise definition of rapid dose escalation. Cumulative antipsychotic dose – alongside other known risk factors - may also be important in the development of NMS
Utilization of focal therapy for patients discontinuing active surveillance of prostate cancer: Recommendations of an international Delphi consensus
BACKGROUND: With the advancement of imaging technology, focal therapy (FT) has been gaining acceptance for the treatment of select patients with localized prostate cancer (CaP). We aim to provide details of a formal physician consensus on the utilization of FT for patients with CaP who are discontinuing active surveillance (AS). METHODS: A 3-stage Delphi consensus on CaP and FT was conducted. Consensus was defined as agreement by ≥80% of physicians. An in-person meeting was attended by 17 panelists to formulate the consensus statement. RESULTS: Fifty-six respondents participated in this interdisciplinary consensus study (82% urologist, 16% radiologist, 2% radiation oncology). The participants confirmed that there is a role for FT in men discontinuing AS (48% strongly agree, 39% agree). The benefit of FT over radical therapy for men coming off AS is: less invasive (91%), has a greater likelihood to preserve erectile function (91%), has a greater likelihood to preserve urinary continence (91%), has fewer side effects (86%), and has early recovery post-treatment (80%). Patients will need to undergo mpMRI of the prostate and/or a saturation biopsy to determine if they are potential candidates for FT. Our limitations include respondent's biases and that the participants of this consensus may not represent the larger medical community. CONCLUSIONS: FT can be offered to men coming off AS between the age of 60 to 80 with grade group 2 localized cancer. This consensus from a multidisciplinary, multi-institutional, international expert panel provides a contemporary insight utilizing FT for CaP in select patients who are discontinuing AS
Distinctive features of the microbiota associated with different forms of apical periodontitis
Microorganisms infecting the dental root canal system play an unequivocal role as causative agents of apical periodontitis. Although fungi, archaea, and viruses have been found in association with some forms of apical periodontitis, bacteria are the main microbial etiologic agents of this disease. Bacteria colonizing the root canal are usually organized in communities similar to biofilm structures. Culture and molecular biology technologies have demonstrated that the endodontic bacterial communities vary in species richness and abundance depending on the different types of infection and different forms of apical periodontitis. This review paper highlights the distinctive features of the endodontic microbiota associated with diverse clinical conditions
Mathematically Gifted Adolescents Have Deficiencies in Social Valuation and Mentalization
Many mathematically gifted adolescents are characterized as being indolent, underachieving and unsuccessful despite their high cognitive ability. This is often due to difficulties with social and emotional development. However, research on social and emotional interactions in gifted adolescents has been limited. The purpose of this study was to observe differences in complex social strategic behaviors between gifted and average adolescents of the same age using the repeated Ultimatum Game. Twenty-two gifted adolescents and 24 average adolescents participated in the Ultimatum Game. Two adolescents participate in the game, one as a proposer and the other as a responder. Because of its simplicity, the Ultimatum Game is an apt tool for investigating complex human emotional and cognitive decision-making in an empirical setting. We observed strategic but socially impaired offers from gifted proposers and lower acceptance rates from gifted responders, resulting in lower total earnings in the Ultimatum Game. Thus, our results indicate that mathematically gifted adolescents have deficiencies in social valuation and mentalization
Experimental loophole-free violation of a Bell inequality using entangled electron spins separated by 1.3 km
For more than 80 years, the counterintuitive predictions of quantum theory
have stimulated debate about the nature of reality. In his seminal work, John
Bell proved that no theory of nature that obeys locality and realism can
reproduce all the predictions of quantum theory. Bell showed that in any local
realist theory the correlations between distant measurements satisfy an
inequality and, moreover, that this inequality can be violated according to
quantum theory. This provided a recipe for experimental tests of the
fundamental principles underlying the laws of nature. In the past decades,
numerous ingenious Bell inequality tests have been reported. However, because
of experimental limitations, all experiments to date required additional
assumptions to obtain a contradiction with local realism, resulting in
loopholes. Here we report on a Bell experiment that is free of any such
additional assumption and thus directly tests the principles underlying Bell's
inequality. We employ an event-ready scheme that enables the generation of
high-fidelity entanglement between distant electron spins. Efficient spin
readout avoids the fair sampling assumption (detection loophole), while the use
of fast random basis selection and readout combined with a spatial separation
of 1.3 km ensure the required locality conditions. We perform 245 trials
testing the CHSH-Bell inequality and find . A
null hypothesis test yields a probability of that a local-realist
model for space-like separated sites produces data with a violation at least as
large as observed, even when allowing for memory in the devices. This result
rules out large classes of local realist theories, and paves the way for
implementing device-independent quantum-secure communication and randomness
certification.Comment: Raw data will be made available after publicatio
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