Economies of space and the school geography curriculum

This paper is about the images of economic space that are found in school curricula. It suggests the importance for educators of evaluating these representations in terms of the messages they contain about how social processes operate. The paper uses school geography texts in Britain since the 1970s to illustrate the different ways in which economic space has been represented to students, before exploring some alternative resources that could be used to provide a wider range of representations of economic space. The paper highlights the continued importance of understanding the politics of school knowledge

Tidal Turbine Benchmarking Exercise: Environmental Characterisation and Geometry Specification

Uncertainty in tidal turbine loading contributes significantly to conservatism in turbine design. This uncertainty originates not only from a lack of knowledge of the flow field at a particular site, but also from lack of understanding of the fundamental physics which govern the loading and performance of tidal turbines in unsteady and turbulent flow regimes. In order to reduce this conservatism and the costs associated, the mathematical and engineering models used in turbine design must be improved. To facilitate the development of these models requires scale experimental data for validation. However, few well-documented experimental data sets are available for tidal turbines, especially at scales large enough to achieve Reynolds number independence and comparability to full scale devices.This paper reports on the initial phases of a tidal turbine benchmarking project that will conduct a large laboratory scale experimental campaign on a highly instrumented 1.6m diameter tidal rotor. The turbine will be tested in well defined flow conditions, including unsteadiness created by free surface waves, as well as freestream turbulence, with instrumentation to determine edgewise and flapwise loading distributions along the blades as they rotate through the unsteady flows. As towing tanks by their nature have low levels of freestream turbulence, a carriage-mounted turbulence grid will be utilised to generate sufficient freestream turbulence in a well-defined manner.In this paper the turbine geometry and test conditions are specified, as well as providing details of the rotor’s hydrodynamic design process. Additionally, the results of a flow characterisation of the carriage-mounted turbulence grid via Acoustic Doppler Velocimetry are presented. The turbulence grid produced a mean turbulence intensity of 3:5% across the region in which the turbine will be tested, and a very uniform flow profile of 0:913 times the upstream velocity

Leukotriene antagonists as first-line or add-on asthma controller therapy

Most randomized trials of treatment for asthma study highly selected patients under idealized conditions. METHODS: We conducted two parallel, multicenter, pragmatic trials to evaluate the real-world effectiveness of a leukotriene-receptor antagonist (LTRA) as compared with either an inhaled glucocorticoid for first-line asthma-controller therapy or a long-acting beta(2)-agonist (LABA) as add-on therapy in patients already receiving inhaled glucocorticoid therapy. Eligible primary care patients 12 to 80 years of age had impaired asthma-related quality of life (Mini Asthma Quality of Life Questionnaire [MiniAQLQ] score =6) or inadequate asthma control (Asthma Control Questionnaire [ACQ] score =1). We randomly assigned patients to 2 years of open-label therapy, under the care of their usual physician, with LTRA (148 patients) or an inhaled glucocorticoid (158 patients) in the first-line controller therapy trial and LTRA (170 patients) or LABA (182 patients) added to an inhaled glucocorticoid in the add-on therapy trial. RESULTS: Mean MiniAQLQ scores increased by 0.8 to 1.0 point over a period of 2 years in both trials. At 2 months, differences in the MiniAQLQ scores between the two treatment groups met our definition of equivalence (95% confidence interval [CI] for an adjusted mean difference, -0.3 to 0.3). At 2 years, mean MiniAQLQ scores approached equivalence, with an adjusted mean difference between treatment groups of -0.11 (95% CI, -0.35 to 0.13) in the first-line controller therapy trial and of -0.11 (95% CI, -0.32 to 0.11) in the add-on therapy trial. Exacerbation rates and ACQ scores did not differ significantly between the two groups. CONCLUSIONS: Study results at 2 months suggest that LTRA was equivalent to an inhaled glucocorticoid as first-line controller therapy and to LABA as add-on therapy for diverse primary care patients. Equivalence was not proved at 2 years. The interpretation of results of pragmatic research may be limited by the crossover between treatment groups and lack of a placebo group

Additional Thoughts on Rigor in Wildlife Science: Unappreciated Impediments

Traditionally, most scientists accepted reductionist and mechanistic approaches as the rigorous way to do science. Sells et al. (2018) recently raised the argument about reliability in wildlife science. Chamberlin (1890), Platt (1964), Romesburg (1981, 1991, 2009), and Williams (1997) were rightly referenced as very influential papers. My intention in this letter is not to refute the essence of the Sells et al. (2018) commentary but to add seldom addressed but important aspects that influence the attainment of rigor and certainty in wildlife studies. The elements of a rigorous approach (i.e., strong inference) as described by Platt (1964) included devising alternative hypotheses, devising ≥1 crucial experiments that will exclude ≥1 of the hypotheses, and carrying out the experiment to get a clean result. The process was then repeated using logical inductive trees (i.e., a continually bifurcated statement hypotheses approach) to obtain the essential cause for the effect. Platt (1964) agreed with Popper (1959) that science advanced only by disproof. He argued that this was a hard doctrine and leads to disputations between scientists, but that Chamberlin\u27s (1890) method of multiple working hypotheses helped to remove that difficulty. Platt (1964) emphasized inductive inference and crucial and critical experiments whereby alternate hypotheses are refuted. Romesburg (1981) explained that in wildlife biology, induction (reliable associations) and retroduction (developing hypotheses) were the basis for almost all wildlife research but were not sufficient. He proposed the hypothetical‐deductive (H‐D) method as a more reliable approach. Citing Harvey (1969), and Popper (1962), Romesburg (1981:294) explained that “Starting with the research hypothesis, usually obtained by retroduction, predictions are made about other classes of facts that should be true if the research hypothesis is actually true.” The hypothesis is then tested indirectly by using logic to deduce one or more test consequences (Romesburg 2014). Data are then collected in a statistical framework. Romesburg (1981) distinguished between a research hypothesis (i.e., a conjecture about some process) versus a statistical hypothesis (i.e., a conjecture about classes of facts encompassed by the process). Williams (1997) clearly explained the differences between necessary and sufficient causation and gave examples of the coherent logic both entailed. He summarized that the science endeavor included theory, hypotheses, predictions, observations, and comparison of predictions against data, and argued that inductive and deductive logic were required for testing hypotheses. Importantly, Williams (1997:1014) recognized that wildlife biology often involves simultaneous complementary explanatory factors, requiring “the framing of many scientifically interesting issues about cause and effect in terms of the relative contribution of multiple causal factors.” Over the years, many others have addressed the issue of rigor and reliability in the Journal of Wildlife Management (JWM) and the Wildlife Society Bulletin (WSB) either directly (McNab 1983, Eberhardt 1988, Anderson 2001) or indirectly (Steidl et al. 1997, Guthery et al. 2001). This is not a complete list and is limited primarily to JWM and WSB but gives an idea of the wide interest in achieving reliable results from wildlife studies

Atom cooling and trapping by disorder

We demonstrate the possibility of three-dimensional cooling of neutral atoms by illuminating them with two counterpropagating laser beams of mutually orthogonal linear polarization, where one of the lasers is a speckle field, i.e. a highly disordered but stationary coherent light field. This configuration gives rise to atom cooling in the transverse plane via a Sisyphus cooling mechanism similar to the one known in standard two-dimensional optical lattices formed by several plane laser waves. However, striking differences occur in the spatial diffusion coefficients as well as in local properties of the trapped atoms.Comment: 11 figures (postscript

Fluorescence-based high-throughput functional profiling of ligand-gated ion channels at the level of single cells

Ion channels are involved in many physiological processes and are attractive targets for therapeutic intervention. Their functional properties vary according to their subunit composition, which in turn varies in a developmental and tissue-specific manner and as a consequence of pathophysiological events. Understanding this diversity requires functional analysis of ion channel properties in large numbers of individual cells. Functional characterisation of ligand-gated channels involves quantitating agonist and drug dose-response relationships using electrophysiological or fluorescence-based techniques. Electrophysiology is limited by low throughput and high-throughput fluorescence-based functional evaluation generally does not enable the characterization of the functional properties of each individual cell. Here we describe a fluorescence-based assay that characterizes functional channel properties at single cell resolution in high throughput mode. It is based on progressive receptor activation and iterative fluorescence imaging and delivers >100 dose-responses in a single well of a 384-well plate, using α1-3 homomeric and αβ heteromeric glycine receptor (GlyR) chloride channels as a model system. We applied this assay with transiently transfected HEK293 cells co-expressing halide-sensitive yellow fluorescent protein and different GlyR subunit combinations. Glycine EC values of different GlyR isoforms were highly correlated with published electrophysiological data and confirm previously reported pharmacological profiles for the GlyR inhibitors, picrotoxin, strychnine and lindane. We show that inter and intra well variability is low and that clustering of functional phenotypes permits identification of drugs with subunit-specific pharmacological profiles. As this method dramatically improves the efficiency with which ion channel populations can be characterized in the context of cellular heterogeneity, it should facilitate systems-level analysis of ion channel properties in health and disease and the discovery of therapeutics to reverse pathological alterations

Physics of Solar Prominences: II - Magnetic Structure and Dynamics

Observations and models of solar prominences are reviewed. We focus on non-eruptive prominences, and describe recent progress in four areas of prominence research: (1) magnetic structure deduced from observations and models, (2) the dynamics of prominence plasmas (formation and flows), (3) Magneto-hydrodynamic (MHD) waves in prominences and (4) the formation and large-scale patterns of the filament channels in which prominences are located. Finally, several outstanding issues in prominence research are discussed, along with observations and models required to resolve them.Comment: 75 pages, 31 pictures, review pape